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Tbio
NDST1
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1

Protein Summary
Description
Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis (PubMed:10758005, PubMed:12634318). Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Compared to other NDST enzymes, its presence is absolutely required. Participates in biosynthesis of heparan sulfate that can ultimately serve as L-selectin ligands, thereby playing a role in inflammatory response (PubMed:10758005, PubMed:12634318). Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). This gene encodes a member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family. The encoded enzyme is a type II transmembrane protein that resides in the Golgi apparatus. The encoded protein cataly ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261797
  • ENSP00000261797
  • ENSG00000070614

Symbol
  • HSST
  • HSST1
  • HSST
  • NST1
  • MRT46
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.96
disease perturbation
0.95
kinase perturbation
0.93
virus perturbation
0.85
co-expressed gene
0.76


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 100.38   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 174   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 100.38   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 174   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
1
1
1
10.7
Non-steroidal anti-inflammatory and antirheumatic product use measurement
1
1
1
0.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
1
10.7
Non-steroidal anti-inflammatory and antirheumatic product use measurement
1
0.9
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
N-deacetylase and N-sulfotransferase 1
VGNC:7090
462194
Macaque
N-deacetylase and N-sulfotransferase 1
712425
Mouse
MGI:104719
15531
Rat
RGD:69303
29633
Dog
N-deacetylase and N-sulfotransferase 1
VGNC:43682
489185
Species
Name
OMA
EggNOG
Inparanoid
Chimp
N-deacetylase and N-sulfotransferase 1
Macaque
N-deacetylase and N-sulfotransferase 1
Mouse
Rat
Dog
N-deacetylase and N-sulfotransferase 1
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (10)
Glycosaminoglycan metabolism (R-HSA-1630316)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycosaminoglycan metabolism
Reactome
HS-GAG biosynthesis
Reactome
Heparan sulfate/heparin (HS-GAG) metabolism
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Name
Explore in Pharos
Explore in Source
Glycosaminoglycan metabolism
HS-GAG biosynthesis
Heparan sulfate/heparin (HS-GAG) metabolism
Metabolism
Metabolism of carbohydrates
Gene Ontology Terms (25)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (78)
1 – 10 of 78
CD83
Tbio
Novelty: 0.00138653
p_int: 0.999907688
p_ni: 0.000092312
Data Source: BioPlex
PLAUR
Tchem
Family: Enzyme
Novelty: 0.00087642
p_int: 0.999391353
p_ni: 0.000608548
p_wrong: 9.8e-8
Score: 0.202
Data Source: BioPlex,STRINGDB
LCN6
Tbio
Novelty: 0.11406686
p_int: 0.997584954
p_ni: 0.002414851
p_wrong: 1.95e-7
Data Source: BioPlex
NAAA
Tchem
Family: Enzyme
Novelty: 0.00368876
p_int: 0.993577179
p_ni: 0.005757433
p_wrong: 0.000665388
Score: 0.181
Data Source: BioPlex,STRINGDB
TAZ
Tbio
Novelty: 0.00372301
p_int: 0.990927102
p_ni: 0.008080555
p_wrong: 0.000992343
Score: 0.311
Data Source: BioPlex,STRINGDB
NRROS
Tbio
Novelty: 0.08976002
p_int: 0.99048657
p_ni: 0.008351632
p_wrong: 0.001161798
Score: 0.189
Data Source: BioPlex,STRINGDB
RLN1
Tbio
Novelty: 0.03992636
p_int: 0.976838689
p_ni: 0.022781071
p_wrong: 0.00038024
Data Source: BioPlex
SCGB2A1
Tbio
Novelty: 0.01902973
p_int: 0.939038843
p_ni: 0.060878557
p_wrong: 0.0000826
Data Source: BioPlex
GPC1
Tbio
Novelty: 0.00293087
Score: 0.963
Data Source: STRINGDB
GPC4
Tbio
Novelty: 0.01319626
Score: 0.961
Data Source: STRINGDB
Publication Statistics
PubMed Score  100.38

PubMed score by year
PubTator Score  38.14

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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