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Tbio
DGKQ
Diacylglycerol kinase theta

Protein Summary
Description
Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). May regulate the activity of protein kinase C by controlling the balance between these two signaling lipids. Activated in the nucleus in response to alpha-thrombin and nerve growth factor (By similarity). May be involved in cAMP-induced activation of NR5A1 and subsequent steroidogenic gene transcription by delivering PA as ligand for NR5A1. Acts synergistically with NR5A1 on CYP17 transcriptional activity. The protein encoded by this gene contains three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain. It is localized in the speckle domains of the nucleus, and mediates the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000273814
  • ENSP00000273814
  • ENSG00000145214

Symbol
  • DAGK4
  • DAGK
  • DAGK4
  • DAGK7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
interacting protein
0.85
protein domain
0.85
metabolite
0.83
cell type or tissue
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.44   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 203   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.44   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 203   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 33
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
2
2
2
95.8
BMI-adjusted waist-hip ratio
1
1
1
92.6
sex hormone-binding globulin measurement
2
1
2
87.1
heel bone mineral density
1
1
1
86
2
1
0
1.2
80.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
2
95.8
BMI-adjusted waist-hip ratio
1
92.6
sex hormone-binding globulin measurement
2
87.1
heel bone mineral density
1
86
0
1.2
80.7
Pathways (13)
Effects of PIP2 hydrolysis (R-HSA-114508)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Effects of PIP2 hydrolysis
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
Hemostasis
Reactome
Platelet activation, signaling and aggregation
Name
Explore in Pharos
Explore in Source
Effects of PIP2 hydrolysis
G alpha (q) signalling events
GPCR downstream signalling
Hemostasis
Platelet activation, signaling and aggregation
Gene Ontology Terms (45)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Genetic Interaction (IGI)
ParkinsonsUK-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (99)
1 – 10 of 99
HAVCR2
Tbio
Novelty: 0.00155885
p_int: 0.998824243
p_ni: 0.000014179
p_wrong: 0.001161579
Score: 0.187
Data Source: BioPlex,STRINGDB
EHD1
Tbio
Novelty: 0.00817602
Score: 0.941
Data Source: STRINGDB
EHD4
Tbio
Novelty: 0.04143584
Score: 0.939
Data Source: STRINGDB
PLD2
Tchem
Family: Enzyme
Novelty: 0.00331129
Score: 0.841
Data Source: STRINGDB
PLCB2
Tbio
Family: Enzyme
Novelty: 0.00571285
Score: 0.815
Data Source: STRINGDB
MBOAT2
Tbio
Family: Enzyme
Novelty: 0.01820899
Score: 0.791
Data Source: STRINGDB
PLCB1
Tbio
Family: Enzyme
Novelty: 0.00269771
Score: 0.787
Data Source: STRINGDB
PLCB3
Tbio
Family: Enzyme
Novelty: 0.01388454
Score: 0.776
Data Source: STRINGDB
PLCB4
Tbio
Family: Enzyme
Novelty: 0.01840915
Score: 0.774
Data Source: STRINGDB
GAK
Tchem
Family: Kinase
Novelty: 0.00731928
Score: 0.773
Data Source: STRINGDB
Publication Statistics
PubMed Score  45.44

PubMed score by year
PubTator Score  13.52

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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