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Tbio
MRPL12
39S ribosomal protein L12, mitochondrial

Protein Summary
Description
Associates with mitochondrial RNA polymerase to activate transcription. Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein which forms homodimers. In prokaryotic ribosomes, two L7/L12 dimers and one L10 protein form the L8 protein complex. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000333676
  • ENSP00000333837
  • ENSG00000262814

Symbol
  • MRPL7
  • RPML12
  • 5c5-2
  • L12mt
  • MRPL7
  • RPML12
  • MRPL7/L12
  • MRP-L31/34
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.93
transcription factor binding site profile
0.93
histone modification site profile
0.9
virus perturbation
0.88
cellular component
0.74


Related Tools
GENEVA
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.65   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 212   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.65   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 212   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1926273
56282
Rat
RGD:1588559
303746
Horse
mitochondrial ribosomal protein L12
100050007
Opossum
mitochondrial ribosomal protein L12
100030209
Anole lizard
mitochondrial ribosomal protein L12
100554093
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Horse
mitochondrial ribosomal protein L12
Opossum
mitochondrial ribosomal protein L12
Anole lizard
mitochondrial ribosomal protein L12
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P52815-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Mitochondrial translation
Reactome
Mitochondrial translation elongation
Reactome
Mitochondrial translation initiation
Reactome
Mitochondrial translation termination
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Mitochondrial translation
Mitochondrial translation elongation
Mitochondrial translation initiation
Mitochondrial translation termination
Gene Ontology Terms (9)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (335)
1 – 10 of 335
CEP131
Tbio
Novelty: 0.02562073
p_int: 0.999999697
p_ni: 2.16e-7
p_wrong: 8.7e-8
Score: 0.172
Data Source: BioPlex,STRINGDB
SEPT10
Tbio
Novelty: 0.14834834
p_int: 0.999999543
p_ni: 4.57e-7
Score: 0.309
Data Source: BioPlex,STRINGDB
FOXP2
Tbio
Family: TF
Novelty: 0.00190504
p_int: 0.999999352
p_ni: 6.48e-7
Data Source: BioPlex
SEPT3
Tbio
Novelty: 0.008513
p_int: 0.999998561
p_ni: 0.000001439
Score: 0.215
Data Source: BioPlex,STRINGDB
SDR39U1
Tdark
Family: Enzyme
Novelty: 0.38626113
p_int: 0.99999789
p_ni: 7.98e-7
p_wrong: 0.000001312
Score: 0.16
Data Source: BioPlex,STRINGDB
FOXP4
Tbio
Family: TF
Novelty: 0.02668451
p_int: 0.999997854
p_ni: 0.000002135
p_wrong: 1.1e-8
Data Source: BioPlex
MTFR1L
Tdark
Novelty: 3.23781609
p_int: 0.999997762
p_ni: 0.000002237
p_wrong: 1e-9
Data Source: BioPlex
GTPBP8
Tdark
Novelty: 4.38933188
p_int: 0.999997734
p_ni: 0.000002266
Score: 0.31
Data Source: BioPlex,STRINGDB
CENPJ
Tbio
Novelty: 0.01337231
p_int: 0.999996785
p_ni: 0.000003202
p_wrong: 1.3e-8
Data Source: BioPlex
MTERF2
Tbio
Novelty: 0.0942186
p_int: 0.999996731
p_ni: 3.59e-7
p_wrong: 0.00000291
Score: 0.556
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  8.65

PubMed score by year
PubTator Score  6.7

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer