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Tbio
EFNA5
Ephrin-A5

Protein Summary
Description
Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Induces compartmentalized signaling within a caveolae-like membrane microdomain when bound to the extracellular domain of its cognate receptor. This signaling event requires the activity of the Fyn tyrosine kinase. Activates the EPHA3 receptor to regulate cell-cell adhesion and cytoskeletal organization. With the receptor EPHA2 may regulate lens fiber cells shape and interactions and be important for lens transparency maintenance. May function actively to stimulate axon fascicu ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000333274
  • ENSP00000328777
  • ENSG00000184349

Symbol
  • EPLG7
  • LERK7
  • AF1
  • EFL5
  • RAGS
  • EPLG7
  • GLC1M
  • LERK7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
transcription factor perturbation
0.84
gene perturbation
0.83
PubMedID
0.82
transcription factor binding site profile
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 748   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 249   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 748   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 249   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
3
4
4
97.2
smoking status measurement
2
1
2
89
mathematical ability
3
3
4
87.7
insomnia measurement
1
3
0
1.1
70.5
smoking initiation
2
1
2
65.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
4
97.2
smoking status measurement
2
89
mathematical ability
4
87.7
insomnia measurement
0
1.1
70.5
smoking initiation
2
65.3
Protein Data Bank (6)
1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (31)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
EPH-Ephrin signaling
Reactome
EPH-ephrin mediated repulsion of cells
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
EPH-Ephrin signaling
EPH-ephrin mediated repulsion of cells
Gene Ontology Terms (32)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Non-traceable Author Statement (NAS)
BHF-UCL
Non-traceable Author Statement (NAS)
BHF-UCL
Non-traceable Author Statement (NAS)
BHF-UCL
Non-traceable Author Statement (NAS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (201)
1 – 10 of 201
EPHA5
Tchem
Family: Kinase
Novelty: 0.01143252
p_int: 0.999997399
p_ni: 3.11e-7
p_wrong: 0.00000229
Score: 0.998
Data Source: BioPlex,STRINGDB
TAP1
Tbio
Novelty: 0.02264011
p_int: 0.999994811
p_ni: 0.000005189
Data Source: BioPlex
TAP2
Tbio
Novelty: 0.0390555
p_int: 0.999989092
p_ni: 0.000010908
Data Source: BioPlex
ATR
Tchem
Family: Kinase
Novelty: 0.00196978
p_int: 0.999950956
p_ni: 0.000049044
Data Source: BioPlex
EPHA7
Tchem
Family: Kinase
Novelty: 0.01065563
p_int: 0.999947839
p_ni: 0.000052161
Score: 0.998
Data Source: BioPlex,STRINGDB
EPHA6
Tchem
Family: Kinase
Novelty: 0.02713974
p_int: 0.999903155
p_ni: 0.000096842
p_wrong: 2e-9
Score: 0.993
Data Source: BioPlex,STRINGDB
EPHA3
Tchem
Family: Kinase
Novelty: 0.00466013
p_int: 0.999878385
p_ni: 0.000121615
Score: 0.999
Data Source: BioPlex,STRINGDB
EPHA8
Tchem
Family: Kinase
Novelty: 0.02244256
p_int: 0.999797375
p_ni: 0.000202533
p_wrong: 9.3e-8
Score: 0.995
Data Source: BioPlex,STRINGDB
EPHA4
Tchem
Family: Kinase
Novelty: 0.00321698
p_int: 0.999418723
p_ni: 0.000581277
Score: 0.999
Data Source: BioPlex,STRINGDB
EPHA2
Tclin
Family: Kinase
Novelty: 0.00191002
p_int: 0.997568562
p_ni: 0.002431438
Score: 0.999
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  748.00

PubMed score by year
PubTator Score  236.88

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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