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Tbio
EFNA4
Ephrin-A4

Protein Summary
Description
Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. May play a role in the interaction between activated B-lymphocytes and dendritic cells in tonsils. This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin. ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359751
  • ENSP00000352789
  • ENSG00000243364
  • ENST00000368409
  • ENSP00000357394
  • ENST00000427683
  • ENSP00000414378

Symbol
  • EPLG4
  • LERK4
  • EFL4
  • EPLG4
  • LERK4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.85
transcription factor binding site profile
0.74
molecular function
0.73
disease perturbation
0.68
gene perturbation
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.29   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 273   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.29   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 273   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (124)
EPHA1
Tchem
Family:  Kinase
Novelty:  0.00136672
Score:  0.996
Data Source:  STRINGDB
EPHA2
Tclin
Family:  Kinase
Novelty:  0.00191002
Score:  0.995
Data Source:  STRINGDB
EPHA8
Tchem
Family:  Kinase
Novelty:  0.02244256
Score:  0.995
Data Source:  STRINGDB
EPHA7
Tchem
Family:  Kinase
Novelty:  0.01065563
Score:  0.995
Data Source:  STRINGDB
EPHA5
Tchem
Family:  Kinase
Novelty:  0.01143252
Score:  0.995
Data Source:  STRINGDB
EPHA4
Tchem
Family:  Kinase
Novelty:  0.00321698
Score:  0.995
Data Source:  STRINGDB
EPHA6
Tchem
Family:  Kinase
Novelty:  0.02713974
Score:  0.995
Data Source:  STRINGDB
EPHA3
Tchem
Family:  Kinase
Novelty:  0.00466013
Score:  0.994
Data Source:  STRINGDB
EPHB2
Tchem
Family:  Kinase
Novelty:  0.00211785
Score:  0.993
Data Source:  STRINGDB
EPHB4
Tchem
Family:  Kinase
Novelty:  0.00422975
Score:  0.993
Data Source:  STRINGDB
Nearest Tclin Targets (19)
Explore Nearest Tclin Targets
Pathways (13)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
EPH-Ephrin signaling
Reactome
EPH-ephrin mediated repulsion of cells
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
EPH-Ephrin signaling
EPH-ephrin mediated repulsion of cells
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (57)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
4
6
5
3.7
98.6
BMI-adjusted waist-hip ratio
10
7
25
97.4
appendicular lean mass
3
5
6
96.4
eosinophil count
5
2
5
92.3
birth weight
4
2
4
91.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
5
3.7
98.6
BMI-adjusted waist-hip ratio
25
97.4
appendicular lean mass
6
96.4
eosinophil count
5
92.3
birth weight
4
91.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ephrin A4
VGNC:9854
469510
Macaque
ephrin A3
717373
Mouse
MGI:106643
13639
Rat
RGD:1307808
310643
Dog
ephrin A4
VGNC:40227
490433
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ephrin A4
Macaque
ephrin A3
Mouse
Rat
Dog
ephrin A4
Publication Statistics
PubMed Score 28.29
PubMed score by year
PubTator Score 12.85
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Text