Protein Summary
Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity). This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and t ...more
- ENST00000368408
- ENSP00000357393
- ENSG00000143590
- EFL2
- EPLG3
- LERK3
- EFL2
- EPLG3
- LERK3
- Ehk1-L
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.73 | ||
gene perturbation | 0.7 | ||
small molecule perturbation | 0.64 | ||
disease perturbation | 0.62 | ||
transcription factor | 0.59 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 48.56 (req: < 5)
Gene RIFs: 10 (req: <= 3)
Antibodies: 312 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 48.56 (req: >= 5)
Gene RIFs: 10 (req: > 3)
Antibodies: 312 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (122)
Nearest Tclin Targets (19)
Downstream (19)
1 – 5 of 19
Pathways (19)
Reactome (4)
KEGG (6)
PathwayCommons (1)
WikiPathways (8)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Axon guidance | ||||
Reactome | Developmental Biology | ||||
Reactome | EPH-Ephrin signaling | ||||
Reactome | EPH-ephrin mediated repulsion of cells | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Axon guidance | ||||
Developmental Biology | ||||
EPH-Ephrin signaling | ||||
EPH-ephrin mediated repulsion of cells | ||||
Viral Interactions (0)
Gene Ontology Terms (10)
Functions (2)
Components (3)
Processes (5)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Disease Associations (null)
GWAS Traits (58)
Items per page:
1 – 5 of 58
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
serum gamma-glutamyl transferase measurement | 3 | 6 | 5 | 3.7 | 99.1 | ||||
urate measurement | 6 | 8 | 12 | 99 | |||||
appendicular lean mass | 3 | 5 | 10 | 98.1 | |||||
serum urea measurement | 1 | 4 | 4 | 97.3 | |||||
BMI-adjusted waist-hip ratio | 9 | 6 | 17 | 96.4 | |||||
Items per page:
1 – 5 of 58
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
serum gamma-glutamyl transferase measurement | 5 | 3.7 | 99.1 | ||||
urate measurement | 12 | 99 | |||||
appendicular lean mass | 10 | 98.1 | |||||
serum urea measurement | 4 | 97.3 | |||||
BMI-adjusted waist-hip ratio | 17 | 96.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | ephrin A3 | VGNC:10610 | 740911 | |||||
Macaque | ephrin A3 | 717373 | ||||||
Mouse | MGI:106644 | 13638 | ||||||
Rat | RGD:620390 | 170901 | ||||||
Dog | ephrin A3 | 100856705 | ||||||
Publication Statistics
PubMed Score 48.56
PubMed score by year
PubTator Score 19.84
PubTator score by year
Related Publications
GeneRif Annotations (10)
Items per page:
0 of 0
PMID | Text |
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