Tbio EFNA3 Ephrin-A3

Protein Summary

Description

Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity). This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P52797
• B7ZAD3
• D3DV85
• Q0VGC9
• Q5SR70

Gene Name

• EFNA3

Ensembl ID

• ENST00000368408
• ENSP00000357393
• ENSG00000143590

Symbol

• EFL2
• EPLG3
• LERK3
• EFL2
• EPLG3
• LERK3
• Ehk1-L

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.73
gene perturbation	0.7
small molecule perturbation	0.64
disease perturbation	0.62
transcription factor	0.59

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.56   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 312   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.56   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 312   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Protein-Protein Interactions (122)

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1 – 10 of 122

• See Interactions on String-DB

EPHA1

Tchem

Family:  Kinase

Novelty:  0.00136672

Score:  0.996

Data Source:  STRINGDB

EPHA4

Tchem

Family:  Kinase

Novelty:  0.00321698

Score:  0.996

Data Source:  STRINGDB

EPHA5

Tchem

Family:  Kinase

Novelty:  0.01143252

Score:  0.995

Data Source:  STRINGDB

EPHA2

Tclin

Family:  Kinase

Novelty:  0.00191002

Score:  0.994

Data Source:  STRINGDB

EPHA7

Tchem

Family:  Kinase

Novelty:  0.01065563

Score:  0.994

Data Source:  STRINGDB

EPHA3

Tchem

Family:  Kinase

Novelty:  0.00466013

Score:  0.994

Data Source:  STRINGDB

EPHB2

Tchem

Family:  Kinase

Novelty:  0.00211785

Score:  0.993

Data Source:  STRINGDB

EPHA8

Tchem

Family:  Kinase

Novelty:  0.02244256

Score:  0.993

Data Source:  STRINGDB

EPHB3

Tchem

Family:  Kinase

Novelty:  0.00746779

Score:  0.993

Data Source:  STRINGDB

EPHB1

Tchem

Family:  Kinase

Novelty:  0.01424716

Score:  0.992

Data Source:  STRINGDB

Pathways (19)

Reactome (4)

KEGG (6)

PathwayCommons (1)

WikiPathways (8)

Axon guidance (R-HSA-422475)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Axon guidance	533 targets	R-HSA-422475
Reactome	Developmental Biology	1055 targets	R-HSA-1266738
Reactome	EPH-Ephrin signaling	92 targets	R-HSA-2682334
Reactome	EPH-ephrin mediated repulsion of cells	49 targets	R-HSA-3928665

Name	Explore in Pharos	Explore in Source
Axon guidance	533 targets	R-HSA-422475
Developmental Biology	1055 targets	R-HSA-1266738
EPH-Ephrin signaling	92 targets	R-HSA-2682334
EPH-ephrin mediated repulsion of cells	49 targets	R-HSA-3928665

Gene Ontology Terms (10)

Functions (2)

Components (3)

Processes (5)

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1 – 2 of 2

GO Term	Evidence	Assigned by
ephrin receptor binding	Inferred from Physical Interaction (IPI)	UniProtKB
transmembrane-ephrin receptor activity	Traceable Author Statement (TAS)	ProtInc

GWAS Traits (58)

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5

1 – 5 of 58

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
serum gamma-glutamyl transferase measurement	EFO_0004532	3	6	5	3.7	99.1
urate measurement	EFO_0004531	6	8	12		99
appendicular lean mass	EFO_0004980	3	5	10		98.1
serum urea measurement	EFO_0009795	1	4	4		97.3
BMI-adjusted waist-hip ratio	EFO_0007788	9	6	17		96.4

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 58

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
serum gamma-glutamyl transferase measurement	EFO_0004532	5	3.7	99.1
urate measurement	EFO_0004531	12		99
appendicular lean mass	EFO_0004980	10		98.1
serum urea measurement	EFO_0009795	4		97.3
BMI-adjusted waist-hip ratio	EFO_0007788	17		96.4

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Cell membrane
Complete proteome
Disulfide bond
Glycoprotein
GPI-anchor
Lipoprotein
Membrane
Polymorphism
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
1,5 anhydroglucitol measurement
age at onset
albuminuria
allergy
appendicular lean mass
aspartate aminotransferase measurement
basal cell carcinoma
biological sex
birth weight
BMI-adjusted hip circumference

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
nervous system phenotype

Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	ephrin A3	VGNC:10610	740911
Macaque	ephrin A3		717373
Mouse	ephrin A3	MGI:106644	13638
Rat	ephrin A3	RGD:620390	170901
Dog	ephrin A3		100856705

Species	Name	OMA	EggNOG	Inparanoid
Chimp	ephrin A3
Macaque	ephrin A3
Mouse	ephrin A3
Rat	ephrin A3
Dog	ephrin A3

Publication Statistics

PubMed Score 48.56

PubMed score by year

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PubTator Score 19.84

PubTator score by year

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