Protein Summary
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 3. Similar to hexokinases 1 and 2, this allosteric enzyme is inhibited by its product glucose-6-phosphate. [provided by RefSeq, Apr 2009]
- ENST00000292432
- ENSP00000292432
- ENSG00000160883
- HXK3
- HKIII
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.96 | ||
tissue sample | 0.66 | ||
protein domain | 0.58 | ||
pathway | 0.56 | ||
gene perturbation | 0.55 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 64.69 (req: < 5)
Gene RIFs: 12 (req: <= 3)
Antibodies: 421 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 64.69 (req: >= 5)
Gene RIFs: 12 (req: > 3)
Antibodies: 421 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (139)
HKDC1
Family: Kinase
Novelty: 0.016969
p_int: 0.999999936
p_ni: 2.6e-8
p_wrong: 3.8e-8
Score: 0.967
Data Source: BioPlex,STRINGDB
NPC2
Novelty: 0.00342898
p_int: 0.999915187
p_ni: 0.000084813
Score: 0.189
Data Source: BioPlex,STRINGDB
SEC22C
Novelty: 0.53697928
p_int: 0.999450006
p_ni: 0.000549994
Score: 0.542
Data Source: BioPlex,STRINGDB
TTC26
Novelty: 0.10088384
p_int: 0.998798256
p_ni: 0.001201744
Score: 0.513
Data Source: BioPlex,STRINGDB
HK2
Family: Kinase
Novelty: 0.00144136
p_int: 0.985486286
p_ni: 0.014513714
Score: 0.967
Data Source: BioPlex,STRINGDB
S1PR1
Family: GPCR
Novelty: 0.00162513
p_int: 0.984871049
p_ni: 0.015128951
Score: 0.202
Data Source: BioPlex,STRINGDB
HK1
Family: Kinase
Novelty: 0.00195554
p_int: 0.979281567
p_ni: 0.020718433
Score: 0.974
Data Source: BioPlex,STRINGDB
TPCN2
Family: IC
Novelty: 0.01351129
p_int: 0.944458657
p_ni: 0.000911535
p_wrong: 0.054629809
Data Source: BioPlex
Nearest Tclin Targets (2)
Upstream (2)
Pathways (29)
Reactome (7)
KEGG (13)
PathwayCommons (3)
UniProt (1)
WikiPathways (5)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Glucose metabolism | ||||
Reactome | Glycolysis | ||||
Reactome | Immune System | ||||
Reactome | Innate Immune System | ||||
Reactome | Metabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Glucose metabolism | ||||
Glycolysis | ||||
Immune System | ||||
Innate Immune System | ||||
Metabolism | ||||
Viral Interactions (0)
Gene Ontology Terms (14)
Functions (6)
Components (4)
Processes (4)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
age at menopause | 2 | 1 | 2 | 81 | |||||
age at menarche | 1 | 1 | 1 | 56 | |||||
self reported educational attainment | 1 | 1 | 1 | 38.2 | |||||
1 | 1 | 0 | 1.1 | 31.4 | |||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
age at menopause | 2 | 81 | |||||
age at menarche | 1 | 56 | |||||
self reported educational attainment | 1 | 38.2 | |||||
0 | 1.1 | 31.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | hexokinase 3 | VGNC:6933 | 462298 | |||||
Macaque | hexokinase 3 | 698120 | ||||||
Mouse | MGI:2670962 | 212032 | ||||||
Rat | RGD:2798 | 25060 | ||||||
Dog | hexokinase 3 | VGNC:41700 | 489096 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | hexokinase 3 | |||||
Macaque | hexokinase 3 | |||||
Mouse | ||||||
Rat | ||||||
Dog | hexokinase 3 | |||||
Publication Statistics
PubMed Score 64.69
PubMed score by year
PubTator Score 46.36
PubTator score by year
Related Publications
Text Mined References (24)
GeneRif Annotations (12)
Items per page:
0 of 0
PMID | Year | Title |
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