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Tbio
HK3
Hexokinase-3

Protein Summary
Description
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 3. Similar to hexokinases 1 and 2, this allosteric enzyme is inhibited by its product glucose-6-phosphate. [provided by RefSeq, Apr 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000292432
  • ENSP00000292432
  • ENSG00000160883

Symbol
  • HXK3
  • HKIII
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
tissue sample
0.66
protein domain
0.58
pathway
0.56
gene perturbation
0.55


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.69   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 421   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.69   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 421   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menopause
2
1
2
81
age at menarche
1
1
1
56
self reported educational attainment
1
1
1
38.2
1
1
0
1.1
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menopause
2
81
age at menarche
1
56
self reported educational attainment
1
38.2
0
1.1
31.4
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
hexokinase 3
VGNC:6933
462298
Macaque
hexokinase 3
698120
Mouse
MGI:2670962
212032
Rat
RGD:2798
25060
Dog
hexokinase 3
VGNC:41700
489096
Species
Name
OMA
EggNOG
Inparanoid
Chimp
hexokinase 3
Macaque
hexokinase 3
Mouse
Rat
Dog
hexokinase 3
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P52790-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (29)
Glucose metabolism (R-HSA-70326)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glucose metabolism
Reactome
Glycolysis
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
Glucose metabolism
Glycolysis
Immune System
Innate Immune System
Metabolism
Gene Ontology Terms (14)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (139)
1 – 10 of 139
HKDC1
Tbio
Family:  Kinase
Novelty:  0.016969
p_int:  0.999999936
p_ni:  2.6e-8
p_wrong:  3.8e-8
Score:  0.967
Data Source:  BioPlex,STRINGDB
NPC2
Tbio
Novelty:  0.00342898
p_int:  0.999915187
p_ni:  0.000084813
Score:  0.189
Data Source:  BioPlex,STRINGDB
SEC22C
Tdark
Novelty:  0.53697928
p_int:  0.999450006
p_ni:  0.000549994
Score:  0.542
Data Source:  BioPlex,STRINGDB
TTC26
Tbio
Novelty:  0.10088384
p_int:  0.998798256
p_ni:  0.001201744
Score:  0.513
Data Source:  BioPlex,STRINGDB
HK2
Tchem
Family:  Kinase
Novelty:  0.00144136
p_int:  0.985486286
p_ni:  0.014513714
Score:  0.967
Data Source:  BioPlex,STRINGDB
S1PR1
Tclin
Family:  GPCR
Novelty:  0.00162513
p_int:  0.984871049
p_ni:  0.015128951
Score:  0.202
Data Source:  BioPlex,STRINGDB
HK1
Tchem
Family:  Kinase
Novelty:  0.00195554
p_int:  0.979281567
p_ni:  0.020718433
Score:  0.974
Data Source:  BioPlex,STRINGDB
TPCN2
Tchem
Family:  IC
Novelty:  0.01351129
p_int:  0.944458657
p_ni:  0.000911535
p_wrong:  0.054629809
Data Source:  BioPlex
GPI
Tbio
Family:  Enzyme
Novelty:  0.00095404
Score:  0.959
Data Source:  STRINGDB
FBP1
Tchem
Family:  Enzyme
Novelty:  0.0029987
Score:  0.943
Data Source:  STRINGDB
Publication Statistics
PubMed Score  64.69

PubMed score by year
PubTator Score  46.36

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer