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Tchem
HK2
Hexokinase-2

Protein Summary
Description
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 2, the predominant form found in skeletal muscle. It localizes to the outer membrane of mitochondria. Expression of this gene is insulin-responsive, and studies in rat suggest that it is involved in the increased rate of glycolysis seen in rapidly growing cancer cells. [provided by RefSeq, Apr 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000290573
  • ENSP00000290573
  • ENSG00000159399

Symbol
  • HKII
  • HXK2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.97
PubMedID
0.82
gene perturbation
0.8
interacting protein
0.8
microRNA
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 737.62   (req: < 5)
Gene RIFs: 119   (req: <= 3)
Antibodies: 630   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 737.62   (req: >= 5)
Gene RIFs: 119   (req: > 3)
Antibodies: 630   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (28)
Glucose metabolism (R-HSA-70326)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glucose metabolism
Reactome
Glycolysis
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Name
Explore in Pharos
Explore in Source
Glucose metabolism
Glycolysis
Metabolism
Metabolism of carbohydrates
Gene Ontology Terms (26)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (184)
1 – 10 of 184
HK1
Tchem
Family: Kinase
Novelty: 0.00195554
p_int: 0.999759841
p_ni: 0.000240159
Score: 0.986
Data Source: BioPlex,STRINGDB
HK3
Tbio
Family: Kinase
Novelty: 0.0151241
p_int: 0.985486286
p_ni: 0.014513714
Score: 0.967
Data Source: BioPlex,STRINGDB
GPI
Tbio
Family: Enzyme
Novelty: 0.00095404
Score: 0.97
Data Source: STRINGDB
G6PD
Tchem
Family: Enzyme
Novelty: 0.00064455
Score: 0.955
Data Source: STRINGDB
PGM1
Tbio
Family: Enzyme
Novelty: 0.00163947
Score: 0.944
Data Source: STRINGDB
FBP1
Tchem
Family: Enzyme
Novelty: 0.0029987
Score: 0.941
Data Source: STRINGDB
GFPT1
Tchem
Family: Enzyme
Novelty: 0.00358283
Score: 0.937
Data Source: STRINGDB
MPI
Tchem
Family: Enzyme
Novelty: 0.0091718
Score: 0.935
Data Source: STRINGDB
GFPT2
Tbio
Family: Enzyme
Novelty: 0.01049877
Score: 0.933
Data Source: STRINGDB
GNPNAT1
Tbio
Family: Enzyme
Novelty: 0.01739665
Score: 0.931
Data Source: STRINGDB
Publication Statistics
PubMed Score  737.62

PubMed score by year
PubTator Score  452.66

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer