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Tchem
SMS
Spermine synthase

Protein Summary
Description
Catalyzes the production of spermine from spermidine and decarboxylated S-adenosylmethionine (dcSAM). This gene encodes a protein belonging to the spermidine/spermin synthase family and catalyzes the production of spermine from spermidine. Pseudogenes of this gene are located on chromosomes 1, 5, 6 and X. Mutations in this gene cause an X-linked intellectual disability called Snyder-Robinson Syndrome (SRS). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379404
  • ENSP00000368714
  • ENSG00000102172
  • ENST00000404933
  • ENSP00000385746

Symbol
  • SRS
  • SpS
  • MRSR
  • SPMSY
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.93
PubMedID
0.92
transcription factor perturbation
0.91
disease perturbation
0.9
virus perturbation
0.88


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.94   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 320   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.94   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 320   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
phosphorus measurement
1
1
1
57.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
phosphorus measurement
1
57.3
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
spermine synthase
698179
Mouse
MGI:109490
20603
Rat
RGD:1564826
363469
Dog
spermine synthase
VGNC:54603
480861
Horse
spermine synthase [Source:HGNC Symbol;Acc:HGNC:11123]
Species
Name
OMA
EggNOG
Inparanoid
Macaque
spermine synthase
Mouse
Rat
Dog
spermine synthase
Horse
spermine synthase [Source:HGNC Symbol;Acc:HGNC:11123]
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P52788-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (14)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Metabolism of polyamines
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of amino acids and derivatives
Metabolism of polyamines
Gene Ontology Terms (6)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (86)
1 – 10 of 86
LAGE3
Tdark
Novelty:  0.02099961
p_int:  0.999999454
p_ni:  3.5e-8
p_wrong:  5.11e-7
Data Source:  BioPlex
AMD1
Tchem
Family:  Enzyme
Novelty:  0.00231813
Score:  0.992
Data Source:  STRINGDB
MTAP
Tchem
Family:  Enzyme
Novelty:  0.00485488
Score:  0.975
Data Source:  STRINGDB
SMOX
Tbio
Family:  Enzyme
Novelty:  0.0071711
Score:  0.964
Data Source:  STRINGDB
MTRR
Tbio
Family:  Enzyme
Novelty:  0.00231914
Score:  0.962
Data Source:  STRINGDB
ENOPH1
Tbio
Family:  Enzyme
Novelty:  0.07679925
Score:  0.955
Data Source:  STRINGDB
SRM
Tchem
Family:  Enzyme
Novelty:  0.01583759
Score:  0.948
Data Source:  STRINGDB
UBA6
Tchem
Novelty:  0.05213412
Score:  0.912
Data Source:  STRINGDB
ODC1
Tclin
Family:  Enzyme
Novelty:  0.00037968
Score:  0.911
Data Source:  STRINGDB
HDLBP
Tbio
Novelty:  0.00979636
Score:  0.839
Data Source:  STRINGDB
Publication Statistics
PubMed Score  31.94

PubMed score by year
PubTator Score  97.94

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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