Tchem SMS Spermine synthase

Protein Summary

Description

Catalyzes the production of spermine from spermidine and decarboxylated S-adenosylmethionine (dcSAM). This gene encodes a protein belonging to the spermidine/spermin synthase family and catalyzes the production of spermine from spermidine. Pseudogenes of this gene are located on chromosomes 1, 5, 6 and X. Mutations in this gene cause an X-linked intellectual disability called Snyder-Robinson Syndrome (SRS). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2017]

Uniprot Accession IDs

• P52788
• A6NHA7
• A6NI34
• B2R9M0
• O00544
• Q9UQS1
• SPMSY

Gene Name

• SMS

Ensembl ID

• ENST00000379404
• ENSP00000368714
• ENSG00000102172
• ENST00000404933
• ENSP00000385746

Symbol

• SRS
• SpS
• MRSR
• SPMSY

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.93
PubMedID	0.92
transcription factor perturbation	0.91
disease perturbation	0.9
virus perturbation	0.88

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.29   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 320   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.29   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 320   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0