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Tbio
RIDA
2-iminobutanoate/2-iminopropanoate deaminase

Protein Summary
Description
Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase. May also function as an endoribonuclease, cleaving mRNA phosphodiester bonds of single-stranded RNA (By similarity). Thereby, may inhibit protein translation (PubMed:8973653).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000254878
  • ENSP00000254878
  • ENSG00000132541

Symbol
  • HRSP12
  • PSP
  • P14.5
  • UK114
  • HRSP12
  • hp14.5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.09   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 152   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.09   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 152   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (3)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Threonine catabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of amino acids and derivatives
Threonine catabolism
Gene Ontology Terms (24)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (58)
1 – 10 of 58
ACOX1
Tbio
Family: Enzyme
Novelty: 0.00626693
p_int: 0.99932713
p_ni: 0.000672869
Score: 0.206
Data Source: BioPlex,STRINGDB
CARM1
Tchem
Family: Epigenetic
Novelty: 0.0078817
p_int: 0.99849296
p_ni: 0.00150704
Score: 0.198
Data Source: BioPlex,STRINGDB
UBB
Tbio
Novelty: 0.00895161
p_int: 0.996694543
p_ni: 0.003305457
Data Source: BioPlex
OGA
Tchem
Family: Enzyme
Novelty: 0.00040103
p_int: 0.972138262
p_ni: 0.027861738
Score: 0.19
Data Source: BioPlex,STRINGDB
SRPRB
Tbio
Novelty: 0.03850629
Score: 0.818
Data Source: STRINGDB
SUGP1
Tbio
Novelty: 0.00769665
Score: 0.816
Data Source: STRINGDB
RBMS1
Tbio
Novelty: 0.00306098
Score: 0.813
Data Source: STRINGDB
SCO2
Tbio
Novelty: 0.00577394
Score: 0.811
Data Source: STRINGDB
PQBP1
Tbio
Novelty: 0.0195288
Score: 0.806
Data Source: STRINGDB
NDUFA7
Tclin
Family: Enzyme
Novelty: 0.40268456
Score: 0.794
Data Source: STRINGDB
Publication Statistics
PubMed Score  63.09

PubMed score by year
PubTator Score  27.81

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer