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Tbio
RBM5
RNA-binding protein 5

Protein Summary
Description
Component of the spliceosome A complex. Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. May both positively and negatively regulate apoptosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes exclusion of exon 6 thereby producing a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes exclusion of exon 9 thereby producing a catalytically active form of CASP2/Caspase-2 that induces apoptosis. This gene is a candidate tumor suppressor gene which encodes a nuclear RNA binding protein that is a component of the spliceosome A complex. The encoded protein plays a role in the induction of cell cycle arrest and apoptosis through pre-mRNA splicing of multiple target genes including the tumor suppressor protein p53. This gene is located within the ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000347869
  • ENSP00000343054
  • ENSG00000003756
  • ENST00000469838
  • ENSP00000419534

Symbol
  • G15
  • H37
  • RMB5
  • LUCA15
  • LUCA-15
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.97
protein domain
0.85
transcription factor perturbation
0.84
ligand (protein) perturbation
0.83
disease perturbation
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.09   (req: < 5)
Gene RIFs: 34   (req: <= 3)
Antibodies: 234   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.09   (req: >= 5)
Gene RIFs: 34   (req: > 3)
Antibodies: 234   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
1
1
0
9.8
95.6
cognitive function measurement
1
1
1
93.7
self reported educational attainment
1
1
1
93.7
chronotype measurement
1
1
1
79.6
high density lipoprotein cholesterol measurement
4
1
4
51.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
0
9.8
95.6
cognitive function measurement
1
93.7
self reported educational attainment
1
93.7
chronotype measurement
1
79.6
high density lipoprotein cholesterol measurement
4
51.3
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RNA binding motif protein 5
VGNC:2531
744612
Macaque
RNA binding motif protein 5
704114
Mouse
MGI:1933204
83486
Rat
RGD:1305059
300996
Dog
RNA binding motif protein 5
VGNC:45424
476618
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RNA binding motif protein 5
Macaque
RNA binding motif protein 5
Mouse
Rat
Dog
RNA binding motif protein 5
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P52756-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (5)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
mRNA Splicing
Reactome
mRNA Splicing - Major Pathway
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Major Pathway
Gene Ontology Terms (14)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (251)
1 – 10 of 251
MLYCD
Tchem
Family: Enzyme
Novelty: 0.01670441
p_int: 0.999995848
p_ni: 0.000004152
Score: 0.524
Data Source: BioPlex,STRINGDB
CCAR1
Tbio
Novelty: 0.03257229
p_int: 0.999995507
p_ni: 0.000004494
Score: 0.919
Data Source: BioPlex,STRINGDB
FBXW11
Tbio
Novelty: 0.0715377
p_int: 0.999952876
p_ni: 0.000047124
Data Source: BioPlex
BTRC
Tbio
Novelty: 0.00293475
p_int: 0.999657787
p_ni: 0.000342191
p_wrong: 2.3e-8
Data Source: BioPlex
DBT
Tbio
Family: Enzyme
Novelty: 0.0070589
p_int: 0.999618283
p_ni: 0.000381717
Data Source: BioPlex
RBM17
Tbio
Novelty: 0.04840999
p_int: 0.998551308
p_ni: 0.001448691
p_wrong: 1e-9
Score: 0.977
Data Source: BioPlex,STRINGDB
ZRSR2
Tbio
Novelty: 0.03449891
p_int: 0.99732225
p_ni: 0.002677745
p_wrong: 4e-9
Score: 0.62
Data Source: BioPlex,STRINGDB
SIRT5
Tchem
Family: Epigenetic
Novelty: 0.00225239
p_int: 0.994192554
p_ni: 0.005679367
p_wrong: 0.000128078
Data Source: BioPlex
SNRPE
Tbio
Novelty: 0.02033423
p_int: 0.92326608
p_ni: 0.076732772
p_wrong: 0.000001148
Score: 0.916
Data Source: BioPlex,STRINGDB
WDR46
Tbio
Novelty: 0.19307408
p_int: 0.900487433
p_ni: 0.09951256
p_wrong: 7e-9
Score: 0.167
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  72.09

PubMed score by year
PubTator Score  82.58

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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