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Tbio
ZNF143
Zinc finger protein 143

Protein Summary
Description
Transcriptional activator. Activates the gene for selenocysteine tRNA (tRNAsec). Binds to the SPH motif of small nuclear RNA (snRNA) gene promoters. Participates in efficient U6 RNA polymerase III transcription via its interaction with CHD8.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000396597
  • ENSP00000379843
  • ENSG00000166478
  • ENST00000396602
  • ENSP00000379847
  • ENST00000396604
  • ENSP00000379849
  • ENST00000530463
  • ENSP00000432154

Symbol
  • SBF
  • STAF
  • SBF
  • STAF
  • pHZ-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.97
transcription factor binding site profile
0.96
histone modification site profile
0.9
disease perturbation
0.83
transcription factor
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 226.45   (req: < 5)
Gene RIFs: 34   (req: <= 3)
Antibodies: 79   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 226.45   (req: >= 5)
Gene RIFs: 34   (req: > 3)
Antibodies: 79   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0