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Tbio
ZNF143
Zinc finger protein 143

Protein Summary
Description
Transcriptional activator. Activates the gene for selenocysteine tRNA (tRNAsec). Binds to the SPH motif of small nuclear RNA (snRNA) gene promoters. Participates in efficient U6 RNA polymerase III transcription via its interaction with CHD8.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000396597
  • ENSP00000379843
  • ENSG00000166478
  • ENST00000396602
  • ENSP00000379847
  • ENST00000396604
  • ENSP00000379849
  • ENST00000530463
  • ENSP00000432154

Symbol
  • SBF
  • STAF
  • SBF
  • STAF
  • pHZ-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.97
transcription factor binding site profile
0.96
histone modification site profile
0.9
disease perturbation
0.83
transcription factor
0.65


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 174.46   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 79   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 174.46   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 79   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
55.2
cutaneous squamous cell carcinoma
1
1
1
9.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
55.2
cutaneous squamous cell carcinoma
1
9.3
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 143
VGNC:12783
451017
Macaque
zinc finger protein 143
703978
Mouse
MGI:1277969
20841
Rat
RGD:1305662
361627
Dog
zinc finger protein 143
VGNC:48661
485384
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 143
Macaque
zinc finger protein 143
Mouse
Rat
Dog
zinc finger protein 143
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P52747-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
RNA Polymerase II Transcription
Reactome
RNA Polymerase III Abortive And Retractive Initiation
Reactome
RNA Polymerase III Transcription
Reactome
RNA Polymerase III Transcription Initiation
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
RNA Polymerase II Transcription
RNA Polymerase III Abortive And Retractive Initiation
RNA Polymerase III Transcription
RNA Polymerase III Transcription Initiation
Gene Ontology Terms (15)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (146)
1 – 10 of 146
RNF26
Tbio
Novelty: 0.40088751
p_int: 0.999999991
p_ni: 8e-9
p_wrong: 1e-9
Score: 0.407
Data Source: BioPlex,STRINGDB
ERCC3
Tbio
Family: Enzyme
Novelty: 0.00978601
p_int: 0.999996955
p_ni: 0.000002929
p_wrong: 1.16e-7
Score: 0.292
Data Source: BioPlex,STRINGDB
SSU72
Tbio
Family: Enzyme
Novelty: 0.02342759
Score: 0.966
Data Source: STRINGDB
GTF2A2
Tbio
Novelty: 0.03391028
Score: 0.944
Data Source: STRINGDB
GTF2B
Tbio
Novelty: 0.00179492
Score: 0.944
Data Source: STRINGDB
TBP
Tbio
Novelty: 0.00034941
Score: 0.944
Data Source: Reactome,STRINGDB
POU2F2
Tbio
Family: TF
Novelty: 0.02531524
Score: 0.939
Data Source: Reactome,STRINGDB
TAF11
Tbio
Novelty: 0.10299251
Score: 0.937
Data Source: STRINGDB
GTF2F1
Tbio
Novelty: 0.02118098
Score: 0.931
Data Source: STRINGDB
POLR3A
Tbio
Family: Enzyme
Novelty: 0.01508849
Score: 0.93
Data Source: STRINGDB
Publication Statistics
PubMed Score  174.46

PubMed score by year
PubTator Score  67.5

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer