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Tbio
ZNF131
Zinc finger protein 131

Protein Summary
Description
Plays a role during development and organogenesis as well as in the function of the adult central nervous system (By similarity). May be involved in transcriptional regulation as a repressor of ESR1/ER-alpha signaling.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000306938
  • ENSP00000305804
  • ENSG00000172262
  • ENST00000505606
  • ENSP00000423945
  • ENST00000509156
  • ENSP00000426504
  • ENST00000509634
  • ENSP00000421246

Symbol
  • ZBTB35
  • pHZ-10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
kinase perturbation
0.84
co-expressed gene
0.76
virus perturbation
0.72
cell line
0.7


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.02   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 261   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.02   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 261   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (53)
MBIP
Tbio
Novelty:  0.05807454
p_int:  0.999999225
p_ni:  2.98e-7
p_wrong:  4.77e-7
Score:  0.169
Data Source:  BioPlex,STRINGDB
ZBTB18
Tbio
Family:  TF
Novelty:  0.03802355
p_int:  0.999997966
p_ni:  0.000001979
p_wrong:  5.5e-8
Score:  0.228
Data Source:  BioPlex,STRINGDB
MRM3
Tbio
Family:  Enzyme
Novelty:  0.06515109
p_int:  0.999997757
p_ni:  0.000002225
p_wrong:  1.8e-8
Score:  0.173
Data Source:  BioPlex,STRINGDB
HINT1
Tchem
Novelty:  0.00815168
p_int:  0.999995955
p_ni:  0.000003781
p_wrong:  2.64e-7
Data Source:  BioPlex
FHL5
Tbio
Novelty:  0.27618006
p_int:  0.999881524
p_ni:  0.000068394
p_wrong:  0.000050083
Score:  0.799
Data Source:  BioPlex,STRINGDB
BACH1
Tbio
Family:  TF
Novelty:  0.04011328
p_int:  0.999870276
p_ni:  0.000079057
p_wrong:  0.000050667
Score:  0.656
Data Source:  BioPlex,STRINGDB
GNB3
Tbio
Novelty:  0.0037117
p_int:  0.939096936
p_ni:  0.030008718
p_wrong:  0.030894346
Score:  0.316
Data Source:  BioPlex,STRINGDB
CBX4
Tchem
Family:  Epigenetic
Novelty:  0.02681197
Score:  0.949
Data Source:  STRINGDB
UHRF2
Tbio
Family:  Epigenetic
Novelty:  0.02205863
Score:  0.946
Data Source:  STRINGDB
UBE2I
Tbio
Novelty:  0.00267883
Score:  0.934
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
SUMO E3 ligases SUMOylate target proteins
Reactome
SUMOylation
Reactome
SUMOylation of transcription cofactors
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational protein modification
SUMO E3 ligases SUMOylate target proteins
SUMOylation
SUMOylation of transcription cofactors
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
2
2
72.8
IGF-1 measurement
1
2
2
68.4
smoking status measurement
2
1
2
67.4
body height
1
1
1
44.2
smoking initiation
1
1
1
44.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
72.8
IGF-1 measurement
2
68.4
smoking status measurement
2
67.4
body height
1
44.2
smoking initiation
1
44.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 131
VGNC:4231
461893
Macaque
zinc finger protein 131
699741
Mouse
MGI:1919715
72465
Rat
RGD:1307638
310375
Dog
zinc finger protein 131
VGNC:48657
479345
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 131
Macaque
zinc finger protein 131
Mouse
Rat
Dog
zinc finger protein 131
Publication Statistics
PubMed Score 8.02
PubMed score by year
PubTator Score 4.43
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title