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Tchem
KIF11
Kinesin-like protein KIF11

Protein Summary
Description
Motor protein required for establishing a bipolar spindle during mitosis (PubMed:19001501). Required in non-mitotic cells for transport of secretory proteins from the Golgi complex to the cell surface (PubMed:23857769). This gene encodes a motor protein that belongs to the kinesin-like protein family. Members of this protein family are known to be involved in various kinds of spindle dynamics. The function of this gene product includes chromosome positioning, centrosome separation and establishing a bipolar spindle during cell mitosis. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000260731
  • ENSP00000260731
  • ENSG00000138160

Symbol
  • EG5
  • KNSL1
  • TRIP5
  • EG5
  • HKSP
  • KNSL1
  • MCLMR
  • TRIP5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
interacting protein
0.98
transcription factor perturbation
0.96
co-expressed gene
0.93
PubMedID
0.86


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 716.72   (req: < 5)
Gene RIFs: 103   (req: <= 3)
Antibodies: 389   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 716.72   (req: >= 5)
Gene RIFs: 103   (req: > 3)
Antibodies: 389   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 622
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0