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Tchem
KIF11
Kinesin-like protein KIF11

Protein Summary
Description
Motor protein required for establishing a bipolar spindle during mitosis (PubMed:19001501). Required in non-mitotic cells for transport of secretory proteins from the Golgi complex to the cell surface (PubMed:23857769). This gene encodes a motor protein that belongs to the kinesin-like protein family. Members of this protein family are known to be involved in various kinds of spindle dynamics. The function of this gene product includes chromosome positioning, centrosome separation and establishing a bipolar spindle during cell mitosis. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000260731
  • ENSP00000260731
  • ENSG00000138160

Symbol
  • EG5
  • KNSL1
  • TRIP5
  • EG5
  • HKSP
  • KNSL1
  • MCLMR
  • TRIP5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
interacting protein
0.98
transcription factor perturbation
0.96
co-expressed gene
0.93
PubMedID
0.86


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 602.07   (req: < 5)
Gene RIFs: 103   (req: <= 3)
Antibodies: 389   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 602.07   (req: >= 5)
Gene RIFs: 103   (req: > 3)
Antibodies: 389   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 598
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
childhood onset asthma
1
1
0
1.1
60.6
2
2
0
1
56.8
red blood cell density measurement
1
1
1
54.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
childhood onset asthma
0
1.1
60.6
0
1
56.8
red blood cell density measurement
1
54.8
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
kinesin family member 11
VGNC:5490
450609
Macaque
kinesin family member 11
699174
Mouse
MGI:1098231
16551
Rat
RGD:621258
171304
Dog
kinesin family member 11
VGNC:42379
477769
Species
Name
OMA
EggNOG
Inparanoid
Chimp
kinesin family member 11
Macaque
kinesin family member 11
Mouse
Rat
Dog
kinesin family member 11
Protein Structure (53 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P52732-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 53
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (11)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
COPI-dependent Golgi-to-ER retrograde traffic
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
Golgi-to-ER retrograde transport
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
COPI-dependent Golgi-to-ER retrograde traffic
Factors involved in megakaryocyte development and platelet production
Golgi-to-ER retrograde transport
Hemostasis
Gene Ontology Terms (26)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (512)
1 – 10 of 512
SPERT
Tbio
Novelty: 0.12255061
p_int: 0.999866039
p_ni: 0.000133961
Score: 0.239
Data Source: BioPlex,STRINGDB
BLOC1S6
Tbio
Novelty: 0.01845286
p_int: 0.999414456
p_ni: 0.000585544
Data Source: BioPlex
MLF1
Tbio
Novelty: 0.0239522
p_int: 0.95864536
p_ni: 0.04135464
Data Source: BioPlex
PRELID2
Tdark
Novelty: 0.38276284
p_int: 0.950040287
p_ni: 0.049959713
Data Source: BioPlex
TFDP3
Tbio
Family: TF
Novelty: 0.00223003
p_int: 0.910533959
p_ni: 0.089466041
Score: 0.239
Data Source: BioPlex,STRINGDB
CASP1
Tchem
Family: Enzyme
Novelty: 0.00034643
p_int: 0.877714632
p_ni: 0.122285368
Score: 0.243
Data Source: BioPlex,STRINGDB
LINC01587
Tdark
Novelty: 0.48128342
p_int: 0.775667374
p_ni: 0.224332626
Score: 0.159
Data Source: BioPlex,STRINGDB
BORCS6
Tdark
Novelty: 0.83789033
p_int: 0.769373855
p_ni: 0.230626145
Data Source: BioPlex
CDK1
Tchem
Family: Kinase
Novelty: 0.00040776
Score: 0.999
Data Source: STRINGDB
KIF23
Tbio
Novelty: 0.00719651
Score: 0.998
Data Source: STRINGDB
Publication Statistics
PubMed Score  602.07

PubMed score by year
PubTator Score  305.44

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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