GTF2A1
Transcription initiation factor IIA subunit 1
Protein Summary
TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity. Accurate transcription initiation on TATA-containing class II genes involves the ordered assembly of RNA polymerase II (POLR2A; MIM 180660) and several general initiation factors (summarized by DeJong and Roeder, 1993 [PubMed 8224848]). One of these factors is TFIIA, which when purified from HeLa extracts consists of 35-, 19-, and 12-kD subunits.[supplied by OMIM, Jul 2010]
- ENST00000434192
- ENSP00000409492
- ENSG00000165417
- ENST00000553612
- ENSP00000452454
- TF2A1
- TF2A1
- TFIIA
- TFIIAL
- TFIIA-42
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 0.97 | ||
transcription factor binding site profile | 0.94 | ||
virus perturbation | 0.88 | ||
ligand (protein) perturbation | 0.83 | ||
transcription factor | 0.81 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 5.03 (req: < 5)
Gene RIFs: 17 (req: <= 3)
Antibodies: 293 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 5.03 (req: >= 5)
Gene RIFs: 17 (req: > 3)
Antibodies: 293 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 3
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0