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Tbio
STAT2
Signal transducer and activator of transcription 2

Protein Summary
Description
Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state (PubMed:9020188, PubMed:23391734). Acts as a regulator of mitochondrial fission by modulating the phosphorylation of DNM1L at 'Ser-616' and 'Ser-637' which activate and inactivate the GTPase activity of DNM1L respectively (PubMed:26122121). The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kin ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314128
  • ENSP00000315768
  • ENSG00000170581
  • ENST00000557235
  • ENSP00000450751

Symbol
  • P113
  • IMD44
  • ISGF-3
  • STAT113
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
virus perturbation
1
histone modification site profile
0.83
interacting protein
0.75
transcription factor binding site profile
0.75


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 468.41   (req: < 5)
Gene RIFs: 92   (req: <= 3)
Antibodies: 931   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 468.41   (req: >= 5)
Gene RIFs: 92   (req: > 3)
Antibodies: 931   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (273)
IRF9
Tbio
Family:  TF
Novelty:  0.00751233
p_int:  1
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
STAT1
Tchem
Family:  TF
Novelty:  0.0003383
p_int:  1
Score:  0.971
Data Source:  BioPlex,Reactome,STRINGDB
ZNF692
Tbio
Family:  TF
Novelty:  0.07012646
p_int:  0.999999294
p_ni:  6.17e-7
p_wrong:  8.9e-8
Data Source:  BioPlex
TACC1
Tbio
Novelty:  0.03556945
p_int:  0.999917728
p_ni:  0.000082252
p_wrong:  2e-8
Score:  0.158
Data Source:  BioPlex,STRINGDB
MYCBP2
Tbio
Family:  Enzyme
Novelty:  0.00413684
p_int:  0.999840277
p_ni:  0.000159723
Score:  0.164
Data Source:  BioPlex,STRINGDB
DPP9
Tchem
Family:  Enzyme
Novelty:  0.00976924
p_int:  0.999811913
p_ni:  0.000188072
p_wrong:  1.5e-8
Data Source:  BioPlex
INSYN2
Tdark
Novelty:  2.55244594
p_int:  0.999780745
p_ni:  0.000219255
Data Source:  BioPlex
LIPT1
Tdark
Family:  Enzyme
Novelty:  0.0546324
p_int:  0.998346019
p_ni:  0.00165391
p_wrong:  7.1e-8
Score:  0.455
Data Source:  BioPlex,STRINGDB
FBXO45
Tbio
Novelty:  0.05784607
p_int:  0.996673164
p_ni:  0.000060706
p_wrong:  0.00326613
Score:  0.159
Data Source:  BioPlex,STRINGDB
TRRAP
Tbio
Novelty:  0.01517245
p_int:  0.991443218
p_ni:  0.008556782
Score:  0.182
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets (7)
Explore Nearest Tclin Targets
1 – 4 of 4
Pathways (82)
Cytokine Signaling in Immune system (R-HSA-1280215)

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Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interferon Signaling
Reactome
Interferon alpha/beta signaling
Reactome
Interleukin-20 family signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interferon Signaling
Interferon alpha/beta signaling
Interleukin-20 family signaling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (15)
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Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
6
6
11
99.5
5
4
0
1.4
95.5
1
2
0
1.5
74.5
body weight
2
2
2
74.2
psoriasis vulgaris
1
1
0
1.4
73.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
11
99.5
0
1.4
95.5
0
1.5
74.5
body weight
2
74.2
psoriasis vulgaris
0
1.4
73.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
signal transducer and activator of transcription 2
VGNC:5604
451996
Macaque
signal transducer and activator of transcription 2
712694
Mouse
MGI:103039
20847
Rat
RGD:1311649
288774
Dog
signal transducer and activator of transcription 2
481111
Species
Name
OMA
EggNOG
Inparanoid
Chimp
signal transducer and activator of transcription 2
Macaque
signal transducer and activator of transcription 2
Mouse
Rat
Dog
signal transducer and activator of transcription 2
Publication Statistics
PubMed Score 468.41
PubMed score by year
PubTator Score 265.75
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title