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Tbio
HNRNPF
Heterogeneous nuclear ribonucleoprotein F

Protein Summary
Description
Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state. This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and regulate alternative splicing, polyadenylation, and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNAs which ha ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000337970
  • ENSP00000338477
  • ENSG00000169813
  • ENST00000356053
  • ENSP00000348345
  • ENST00000357065
  • ENSP00000349573
  • ENST00000443950
  • ENSP00000400433
  • ENST00000544000
  • ENSP00000438061

Symbol
  • HNRPF
  • HNRPF
  • mcs94-1
  • OK/SW-cl.23
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
hub protein
0.98
transcription factor binding site profile
0.95
protein complex
0.74
microRNA
0.73


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.14   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 314   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.14   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 314   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
heterogeneous nuclear ribonucleoprotein F
VGNC:4712
466053
Macaque
heterogeneous nuclear ribonucleoprotein F
717668
Mouse
MGI:2138741
98758
Rat
RGD:620366
64200
Dog
heterogeneous nuclear ribonucleoprotein F
VGNC:41730
477757
Species
Name
OMA
EggNOG
Inparanoid
Chimp
heterogeneous nuclear ribonucleoprotein F
Macaque
heterogeneous nuclear ribonucleoprotein F
Mouse
Rat
Dog
heterogeneous nuclear ribonucleoprotein F
Protein Structure (7 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P52597-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (16)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
FGFR2 alternative splicing
Reactome
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Reactome
Immune System
Reactome
Interleukin-12 family signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
FGFR2 alternative splicing
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Immune System
Interleukin-12 family signaling
Gene Ontology Terms (15)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (297)
1 – 10 of 297
PECR
Tbio
Family: Enzyme
Novelty: 0.01550165
p_int: 0.999997584
p_ni: 0.000002416
Score: 0.189
Data Source: BioPlex,STRINGDB
HSD17B8
Tbio
Family: Enzyme
Novelty: 0.00915958
p_int: 0.999963113
p_ni: 0.000036887
Score: 0.171
Data Source: BioPlex,STRINGDB
AMMECR1
Tbio
Novelty: 0.12679247
p_int: 0.999270831
p_ni: 0.000729169
Score: 0.188
Data Source: BioPlex,STRINGDB
ARHGEF39
Tdark
Novelty: 0.30447134
p_int: 0.971824364
p_ni: 0.028175636
Data Source: BioPlex
CDKN2AIP
Tbio
Novelty: 0.15331029
p_int: 0.970616637
p_ni: 0.025953531
p_wrong: 0.003429832
Score: 0.218
Data Source: BioPlex,STRINGDB
ANGEL2
Tbio
Novelty: 0.26130802
p_int: 0.955297681
p_ni: 0.044702319
Score: 0.186
Data Source: BioPlex,STRINGDB
RBM7
Tbio
Novelty: 0.07482689
p_int: 0.954624656
p_ni: 0.045375344
Score: 0.348
Data Source: BioPlex,STRINGDB
STN1
Tbio
Novelty: 0.01309587
p_int: 0.935782554
p_ni: 0.064217446
Score: 0.165
Data Source: BioPlex,STRINGDB
SUPV3L1
Tbio
Family: Enzyme
Novelty: 0.01598799
p_int: 0.896151742
p_ni: 0.103848258
Score: 0.179
Data Source: BioPlex,STRINGDB
ZCCHC8
Tbio
Novelty: 0.14887134
p_int: 0.854293973
p_ni: 0.145706026
p_wrong: 1e-9
Score: 0.547
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  52.14

PubMed score by year
PubTator Score  32.21

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer