Tbio AGFG1 Arf-GAP domain and FG repeat-containing protein 1

Protein Summary

Description

Required for vesicle docking or fusion during acrosome biogenesis (By similarity). May play a role in RNA trafficking or localization. In case of infection by HIV-1, acts as a cofactor for viral Rev and promotes movement of Rev-responsive element-containing RNAs from the nuclear periphery to the cytoplasm. This step is essential for HIV-1 replication. The protein encoded by this gene is related to nucleoporins, a class of proteins that mediate nucleocytoplasmic transport. The encoded protein binds the activation domain of the human immunodeficiency virus Rev protein when Rev is assembled onto its RNA target, and is required for the nuclear export of Rev-directed RNAs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

Uniprot Accession IDs

• P52594
• B3KUL1
• E9PHX7
• Q15277
• Q4VAS0
• Q4VAS1
• Q4VAS3
• Q53QT8
• Q53R11

Gene Name

• AGFG1

Ensembl ID

• ENST00000310078
• ENSP00000312059
• ENSG00000173744
• ENST00000373671
• ENSP00000362775
• ENST00000409171
• ENSP00000387218
• ENST00000409979
• ENSP00000387282

Symbol

• HRB
• RAB
• RIP
• HRB
• RAB
• RIP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	1
disease perturbation	0.87
transcription factor binding site profile	0.85
microRNA	0.77
interacting protein	0.65

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 451.57   (req: < 5)

Gene RIFs: 16   (req: <= 3)

Antibodies: 200   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 451.57   (req: >= 5)

Gene RIFs: 16   (req: > 3)

Antibodies: 200   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0