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Tbio
AGFG1
Arf-GAP domain and FG repeat-containing protein 1

Protein Summary
Description
Required for vesicle docking or fusion during acrosome biogenesis (By similarity). May play a role in RNA trafficking or localization. In case of infection by HIV-1, acts as a cofactor for viral Rev and promotes movement of Rev-responsive element-containing RNAs from the nuclear periphery to the cytoplasm. This step is essential for HIV-1 replication. The protein encoded by this gene is related to nucleoporins, a class of proteins that mediate nucleocytoplasmic transport. The encoded protein binds the activation domain of the human immunodeficiency virus Rev protein when Rev is assembled onto its RNA target, and is required for the nuclear export of Rev-directed RNAs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310078
  • ENSP00000312059
  • ENSG00000173744
  • ENST00000373671
  • ENSP00000362775
  • ENST00000409171
  • ENSP00000387218
  • ENST00000409979
  • ENSP00000387282

Symbol
  • HRB
  • RAB
  • RIP
  • HRB
  • RAB
  • RIP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
disease perturbation
0.87
transcription factor binding site profile
0.85
microRNA
0.77
interacting protein
0.65


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 757.4   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 200   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 757.4   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 200   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
influenza A (H1N1)
1
1
0
5.2
9.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
influenza A (H1N1)
0
5.2
9.8
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ArfGAP with FG repeats 1
VGNC:10553
459990
Mouse
MGI:1333754
15463
Rat
RGD:1560041
363266
Dog
ArfGAP with FG repeats 1
VGNC:37700
477395
Cow
ArfGAP with FG repeats 1
VGNC:25725
536149
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ArfGAP with FG repeats 1
Mouse
Rat
Dog
ArfGAP with FG repeats 1
Cow
ArfGAP with FG repeats 1
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P52594-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
Cargo recognition for clathrin-mediated endocytosis (R-HSA-8856825)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Clathrin-mediated endocytosis
Reactome
Membrane Trafficking
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Membrane Trafficking
Vesicle-mediated transport
Gene Ontology Terms (16)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (247)
1 – 10 of 247
AGFG2
Tbio
Novelty: 0.10320266
p_int: 0.999997367
p_ni: 0.000002633
Score: 0.714
Data Source: BioPlex,STRINGDB
PIP
Tbio
Novelty: 0.00208509
p_int: 0.936931304
p_ni: 0.063027478
p_wrong: 0.000041218
Data Source: BioPlex
VAMP7
Tbio
Novelty: 0.00900603
Score: 0.98
Data Source: Reactome,STRINGDB
EPS15
Tbio
Novelty: 0.00451447
Score: 0.98
Data Source: STRINGDB
EPS15L1
Tbio
Novelty: 0.06929299
Score: 0.97
Data Source: STRINGDB
RAB5A
Tbio
Family: Enzyme
Novelty: 0.00111347
Score: 0.97
Data Source: STRINGDB
FCHO2
Tbio
Novelty: 0.12302279
Score: 0.968
Data Source: STRINGDB
STON2
Tbio
Novelty: 0.02098671
Score: 0.959
Data Source: STRINGDB
RAB5C
Tbio
Family: Enzyme
Novelty: 0.02952779
Score: 0.958
Data Source: STRINGDB
RAB5B
Tbio
Family: Enzyme
Novelty: 0.02653775
Score: 0.958
Data Source: STRINGDB
Publication Statistics
PubMed Score  757.40

PubMed score by year
PubTator Score  102.49

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer