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Tbio
SLC7A2
Cationic amino acid transporter 2

Protein Summary
Description
Functions as permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine); the affinity for its substrates differs between isoforms created by alternative splicing. Isoform 1 functions as permease that mediates the transport of the cationic amino acids (arginine, lysine and ornithine), and it has much higher affinity for arginine than isoform 2. Isoform 2 functions as low-affinity, high capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) (PubMed:9174363). May play a role in classical or alternative activation of macrophages via its role in arginine transport. The protein encoded by this gene is a cationic amino acid transporter and a member of the APC (amino acid-polyamine-organocation) family of transporters. The encoded membrane protein is responsible for the cellular uptake of arginine, lysine and ornithine. Three transcript variants encoding different isoforms have been found for this gene. [pro ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000004531
  • ENSP00000004531
  • ENSG00000003989
  • ENST00000398090
  • ENSP00000381164
  • ENST00000470360
  • ENSP00000419873
  • ENST00000494857
  • ENSP00000419140
  • ENST00000522656
  • ENSP00000430464

Symbol
  • ATRC2
  • CAT2
  • CAT2
  • ATRC2
  • HCAT2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.96
transcription factor perturbation
0.94
molecular function
0.81
microRNA
0.8
biological process
0.69


Related Tools
RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.35   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 101   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.35   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 101   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
amino acid measurement
1
2
3
56.7
diastolic blood pressure
1
1
1
29
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
amino acid measurement
3
56.7
diastolic blood pressure
1
29
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 7 member 2
VGNC:14592
740548
Mouse
MGI:99828
11988
Rat
RGD:68387
64554
Dog
solute carrier family 7 member 2
VGNC:46474
475614
Horse
solute carrier family 7 member 2
VGNC:23270
100050240
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 7 member 2
Mouse
Rat
Dog
solute carrier family 7 member 2
Horse
solute carrier family 7 member 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P52569-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Amino acid transport across the plasma membrane (R-HSA-352230)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amino acid transport across the plasma membrane
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of inorganic cations/anions and amino acids/oligopeptides
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Amino acid transport across the plasma membrane
SLC-mediated transmembrane transport
Transport of inorganic cations/anions and amino acids/oligopeptides
Transport of small molecules
Gene Ontology Terms (19)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (78)
1 – 10 of 78
CD83
Tbio
Novelty: 0.00138653
p_int: 0.999654692
p_ni: 0.000345308
Data Source: BioPlex
ANKRD22
Tdark
Novelty: 0.28856283
p_int: 0.998411817
p_ni: 0.001588182
p_wrong: 1e-9
Data Source: BioPlex
ATP6V0E1
Tbio
Family: Enzyme
Novelty: 0.076209
p_int: 0.997464508
p_ni: 0.002535492
Data Source: BioPlex
TPST2
Tbio
Family: Enzyme
Novelty: 0.02551048
p_int: 0.995483452
p_ni: 0.004516341
p_wrong: 2.07e-7
Data Source: BioPlex
FPR2
Tchem
Family: GPCR
Novelty: 0.00228744
p_int: 0.993422566
p_ni: 0.006577434
Score: 0.158
Data Source: BioPlex,STRINGDB
DLK2
Tbio
Novelty: 0.06366405
p_int: 0.990743186
p_ni: 0.009256814
Data Source: BioPlex
OPALIN
Tdark
Novelty: 0.08221612
p_int: 0.97910464
p_ni: 0.020894932
p_wrong: 4.28e-7
Data Source: BioPlex
TSPAN31
Tbio
Novelty: 0.13580467
p_int: 0.978662246
p_ni: 0.021331915
p_wrong: 0.00000584
Score: 0.213
Data Source: BioPlex,STRINGDB
VSTM1
Tbio
Novelty: 0.08630646
p_int: 0.97801787
p_ni: 0.020543775
p_wrong: 0.001438355
Data Source: BioPlex
NAT8B
Tbio
Family: Enzyme
p_int: 0.977846833
p_ni: 0.022152396
p_wrong: 7.71e-7
Data Source: BioPlex
Publication Statistics
PubMed Score  47.35

PubMed score by year
PubTator Score  122.85

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer