Tbio ARHGDIB Rho GDP-dissociation inhibitor 2

Protein Summary

Description

Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them (PubMed:8356058, PubMed:7512369). Regulates reorganization of the actin cytoskeleton mediated by Rho family members (PubMed:8262133). Members of the Rho (or ARH) protein family (see MIM 165390) and other Ras-related small GTP-binding proteins (see MIM 179520) are involved in diverse cellular events, including cell signaling, proliferation, cytoskeletal organization, and secretion. The GTP-binding proteins are active only in the GTP-bound state. At least 3 classes of proteins tightly regulate cycling between the GTP-bound and GDP-bound states: GTPase-activating proteins (GAPs), guanine nucleotide-releasing factors (GRFs), and GDP-dissociation inhibitors (GDIs). The GDIs, including ARHGDIB, decrease the rate of GDP dissociation from Ras-like GTPases (summary by Scherle et al., 1993 [PubMed 8356058]).[supplied by OMIM, Dec 2010]

Uniprot Accession IDs

• P52566
• B5BU79
• Rho GDI 2

Gene Name

• ARHGDIB

Ensembl ID

• ENST00000228945
• ENSP00000228945
• ENSG00000111348
• ENST00000541546
• ENSP00000440560
• ENST00000541644
• ENSP00000444860

Symbol

• GDIA2
• GDID4
• RAP1GN1
• D4
• GDIA2
• GDID4
• LYGDI
• Ly-GDI
• RAP1GN1
• RhoGDI2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.95
disease perturbation	0.9
small molecule perturbation	0.9
gene perturbation	0.75
tissue sample	0.73

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Rho Gdp-dissociation Inhibitor 2

Protein / Enzyme Modulator / G-protein Modulator / Rho Gdp-dissociation Inhibitor 2

DTO Classes

Protein / Enzyme Modulator / G-protein Modulator / Rho Gdp-dissociation Inhibitor 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 128.95   (req: < 5)

Gene RIFs: 52   (req: <= 3)

Antibodies: 494   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 128.95   (req: >= 5)

Gene RIFs: 52   (req: > 3)

Antibodies: 494   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0