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Tchem
ARHGDIA
Rho GDP-dissociation inhibitor 1

Protein Summary
Description
Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms. Through the modulation of Rho proteins, may play a role in cell motility regulation. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1. This gene encodes a protein that plays a key role in the regulation of signaling through Rho GTPases. The encoded protein inhibits the disassociation of Rho family members from GDP (guanine diphosphate), thereby maintaining ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000269321
  • ENSP00000269321
  • ENSG00000141522
  • ENST00000400721
  • ENSP00000383556
  • ENST00000541078
  • ENSP00000441348
  • ENST00000580685
  • ENSP00000464205

Symbol
  • GDIA1
  • GDIA1
  • NPHS8
  • RHOGDI
  • RHOGDI-1
  • HEL-S-47e
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.91
transcription factor perturbation
0.88
disease
0.85
hub protein
0.82
disease perturbation
0.79


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 377.68   (req: < 5)
Gene RIFs: 59   (req: <= 3)
Antibodies: 516   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 377.68   (req: >= 5)
Gene RIFs: 59   (req: > 3)
Antibodies: 516   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Rho GDP dissociation inhibitor alpha
VGNC:9458
454971
Mouse
MGI:2178103
192662
Rat
RGD:1359547
360678
Dog
Rho GDP dissociation inhibitor alpha
VGNC:38069
475924
Horse
Rho GDP dissociation inhibitor alpha
VGNC:15480
100049942
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Rho GDP dissociation inhibitor alpha
Mouse
Rat
Dog
Rho GDP dissociation inhibitor alpha
Horse
Rho GDP dissociation inhibitor alpha
Protein Structure (20 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P52565-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 20
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (19)
Axonal growth inhibition (RHOA activation) (R-HSA-193634)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axonal growth inhibition (RHOA activation)
Reactome
Axonal growth stimulation
Reactome
Death Receptor Signalling
Reactome
Rho GTPase cycle
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Axonal growth inhibition (RHOA activation)
Axonal growth stimulation
Death Receptor Signalling
Rho GTPase cycle
Signal Transduction
Gene Ontology Terms (16)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (159)
1 – 10 of 159
RHOA
Tbio
Family: Enzyme
Novelty: 0.00022204
Score: 0.999
Data Source: Reactome,STRINGDB
CDC42
Tchem
Family: Enzyme
Novelty: 0.00032619
Score: 0.998
Data Source: STRINGDB
NGFR
Tclin
Novelty: 0.00072052
Score: 0.997
Data Source: Reactome,STRINGDB
RHOC
Tbio
Family: Enzyme
Novelty: 0.00262213
Score: 0.996
Data Source: STRINGDB
RAC2
Tbio
Family: Enzyme
Novelty: 0.00116234
Score: 0.992
Data Source: STRINGDB
RAC1
Tbio
Family: Enzyme
Novelty: 0.00365325
Score: 0.992
Data Source: STRINGDB
RHOB
Tbio
Family: Enzyme
Novelty: 0.0019205
Score: 0.991
Data Source: STRINGDB
RHOG
Tbio
Family: Enzyme
Novelty: 0.00412327
Score: 0.989
Data Source: STRINGDB
RAC3
Tbio
Family: Enzyme
Novelty: 0.02125361
Score: 0.983
Data Source: STRINGDB
RHOD
Tbio
Family: Enzyme
Novelty: 0.0029764
Score: 0.978
Data Source: STRINGDB
Publication Statistics
PubMed Score  377.68

PubMed score by year
PubTator Score  147.31

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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