Tchem ARHGDIA Rho GDP-dissociation inhibitor 1

Protein Summary

Description

Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms. Through the modulation of Rho proteins, may play a role in cell motility regulation. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1. This gene encodes a protein that plays a key role in the regulation of signaling through Rho GTPases. The encoded protein inhibits the disassociation of Rho family members from GDP (guanine diphosphate), thereby maintaining these factors in an inactive state. Activity of this protein is important in a variety of cellular processes, and expression of this gene may be altered in tumors. Mutations in this gene have been found in individuals with nephrotic syndrome, type 8. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Uniprot Accession IDs

• P52565
• A8MXW0
• B2R5X1
• B4DDD3
• B4DUV9
• Q6IBM5
• Rho GDI 1

Gene Name

• ARHGDIA

Ensembl ID

• ENST00000269321
• ENSP00000269321
• ENSG00000141522
• ENST00000400721
• ENSP00000383556
• ENST00000541078
• ENSP00000441348
• ENST00000580685
• ENSP00000464205

Symbol

• GDIA1
• GDIA1
• NPHS8
• RHOGDI
• RHOGDI-1
• HEL-S-47e

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.91
transcription factor perturbation	0.88
disease	0.85
hub protein	0.82
disease perturbation	0.79

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Rho Gdp-dissociation Inhibitor 1

Protein / Enzyme Modulator / G-protein Modulator / Rho Gdp-dissociation Inhibitor 1

DTO Classes

Protein / Enzyme Modulator / G-protein Modulator / Rho Gdp-dissociation Inhibitor 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 470.42   (req: < 5)

Gene RIFs: 62   (req: <= 3)

Antibodies: 516   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 470.42   (req: >= 5)

Gene RIFs: 62   (req: > 3)

Antibodies: 516   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0