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Tchem
MAP2K6
Dual specificity mitogen-activated protein kinase kinase 6

Protein Summary
Description
Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. With MAP3K3/MKK3, catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinases p38 MAPK11, MAPK12, MAPK13 and MAPK14 and plays an important role in the regulation of cellular responses to cytokines and all kinds of stresses. Especially, MAP2K3/MKK3 and MAP2K6/MKK6 are both essential for the activation of MAPK11 and MAPK13 induced by environmental stress, whereas MAP2K6/MKK6 is the major MAPK11 activator in response to TNF. MAP2K6/MKK6 also phosphorylates and activates PAK6. The p38 MAP kinase signal transduction pathway leads to direct activation of transcription factors. Nuclear targets of p38 MAP kinase include the transcription factors ATF2 and ELK1. Within the p38 MAPK signal transduction pathway, MAP3K6/MKK6 mediates phosphorylation of STAT4 through MAPK14 activation, and is therefore required for STAT4 activation and STAT4-regul ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000589647
  • ENSP00000467213
  • ENSG00000108984
  • ENST00000590474
  • ENSP00000468348
  • ENST00000613873
  • ENSP00000477701

Symbol
  • MEK6
  • MKK6
  • PRKMK6
  • SKK3
  • MEK6
  • MKK6
  • MAPKK6
  • PRKMK6
  • SAPKK3
  • SAPKK-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
0.99
virus perturbation
0.96
gene perturbation
0.95
pathway
0.92


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 140.53   (req: < 5)
Gene RIFs: 42   (req: <= 3)
Antibodies: 805   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 140.53   (req: >= 5)
Gene RIFs: 42   (req: > 3)
Antibodies: 805   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (153)
1 – 10 of 153
MAP2K3
Tchem
Family:  Kinase
Novelty:  0.00349605
p_int:  1
Score:  0.97
Data Source:  BioPlex,STRINGDB
CST1
Tbio
Novelty:  0.02399609
p_int:  0.854599521
p_ni:  0.145364077
p_wrong:  0.000036402
Score:  0.187
Data Source:  BioPlex,STRINGDB
MAP3K7
Tchem
Family:  Kinase
Novelty:  0.00540177
Score:  0.999
Data Source:  Reactome,STRINGDB
TLR3
Tbio
Novelty:  0.00057048
Score:  0.994
Data Source:  STRINGDB
MAPK14
Tchem
Family:  Kinase
Novelty:  0.00045138
Score:  0.992
Data Source:  Reactome,STRINGDB
MAPK11
Tchem
Family:  Kinase
Novelty:  0.00545217
Score:  0.984
Data Source:  Reactome,STRINGDB
MAPK13
Tchem
Family:  Kinase
Novelty:  0.01071621
Score:  0.977
Data Source:  STRINGDB
MAPK12
Tchem
Family:  Kinase
Novelty:  0.00835017
Score:  0.977
Data Source:  STRINGDB
MAP3K4
Tbio
Family:  Kinase
Novelty:  0.02186397
Score:  0.976
Data Source:  STRINGDB
TAOK2
Tchem
Family:  Kinase
Novelty:  0.0232708
Score:  0.975
Data Source:  STRINGDB
Pathways (138)
Cellular Senescence (R-HSA-2559583)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 44
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Cytokine Signaling in Immune system
Reactome
Developmental Biology
Name
Explore in Pharos
Explore in Source
Cellular Senescence
Cellular responses to external stimuli
Cellular responses to stress
Cytokine Signaling in Immune system
Developmental Biology
Gene Ontology Terms (29)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
1
3
3
96.7
apolipoprotein B measurement
1
3
3
95.9
total cholesterol measurement
1
3
3
95.2
serum albumin measurement
1
2
2
93.8
blood protein measurement
1
1
1
71.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
3
96.7
apolipoprotein B measurement
3
95.9
total cholesterol measurement
3
95.2
serum albumin measurement
2
93.8
blood protein measurement
1
71.9
Find similar targets by:
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitogen-activated protein kinase kinase 6
VGNC:9365
468310
Macaque
mitogen-activated protein kinase kinase 6
693914
Mouse
MGI:1346870
26399
Rat
RGD:620666
114495
Dog
mitogen-activated protein kinase kinase 6
VGNC:42964
480454
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitogen-activated protein kinase kinase 6
Macaque
mitogen-activated protein kinase kinase 6
Mouse
Rat
Dog
mitogen-activated protein kinase kinase 6
Publication Statistics
PubMed Score 140.53
PubMed score by year
PubTator Score 144.35
PubTator score by year
Patents
Patents by year