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Tbio
POLR2H
DNA-directed RNA polymerases I, II, and III subunit RPABC3

Protein Summary
Description
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. The three eukaryotic RNA polymerases are complex multisubunit enzymes that play a central role in the transcription of nuclear genes. This gene encodes an essential and highly conserved subunit of RNA polymerase II that is shared by the other two eukaryotic DNA-directed RNA polymerases, I and III. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000429568
  • ENSP00000415536
  • ENSG00000163882
  • ENST00000430783
  • ENSP00000411883
  • ENST00000438240
  • ENSP00000398622
  • ENST00000443489
  • ENSP00000393773
  • ENST00000452961
  • ENSP00000399882
  • ENST00000456318
  • ENSP00000392913

Symbol
  • RPB8
  • RPB17
  • RPABC3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
virus perturbation
0.99
interacting protein
0.98
biological process
0.87
disease perturbation
0.87


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.46   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 226   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.46   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 226   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (625)
POLR2G
Tbio
Family:  Enzyme
Novelty:  0.01235379
p_int:  0.836433409
p_ni:  0.163566591
Score:  0.999
Data Source:  BioPlex,STRINGDB
POLR2J
Tbio
Family:  Enzyme
Novelty:  0.02344868
p_int:  0.830498122
p_ni:  0.169501878
Score:  0.998
Data Source:  BioPlex,STRINGDB
POLR3K
Tbio
Family:  Enzyme
Novelty:  0.07105011
p_int:  0.824495193
p_ni:  0.175504807
Score:  0.994
Data Source:  BioPlex,STRINGDB
POLR1C
Tbio
Family:  Enzyme
Novelty:  0.04485332
Score:  0.999
Data Source:  STRINGDB
POLR3B
Tbio
Family:  Enzyme
Novelty:  0.02526167
Score:  0.999
Data Source:  STRINGDB
POLR3D
Tbio
Family:  Enzyme
Novelty:  0.02616321
Score:  0.999
Data Source:  STRINGDB
POLR2I
Tbio
Family:  Enzyme
Novelty:  0.03100605
Score:  0.999
Data Source:  STRINGDB
P0DPB6
Tbio
Family:  Enzyme
Novelty:  0.01598347
Score:  0.999
Data Source:  STRINGDB
POLR2E
Tbio
Family:  Enzyme
Novelty:  0.01817288
Score:  0.999
Data Source:  STRINGDB
POLR2F
Tbio
Family:  Enzyme
Novelty:  0.03787683
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (100)
Abortive elongation of HIV-1 transcript in the absence of Tat (R-HSA-167242)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 91
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Abortive elongation of HIV-1 transcript in the absence of Tat
Reactome
Activation of HOX genes during differentiation
Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Reactome
B-WICH complex positively regulates rRNA expression
Reactome
Cytosolic sensors of pathogen-associated DNA
Name
Explore in Pharos
Explore in Source
Abortive elongation of HIV-1 transcript in the absence of Tat
Activation of HOX genes during differentiation
Activation of anterior HOX genes in hindbrain development during early embryogenesis
B-WICH complex positively regulates rRNA expression
Cytosolic sensors of pathogen-associated DNA
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
2
9
12
99.5
platelet count
5
9
15
99.4
appendicular lean mass
4
2
4
92.2
hematological measurement
1
1
1
84.2
daytime rest measurement
1
1
1
74.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
12
99.5
platelet count
15
99.4
appendicular lean mass
4
92.2
hematological measurement
1
84.2
daytime rest measurement
1
74.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
RNA polymerase II subunit H
100429040
Mouse
MGI:2384309
245841
Horse
RNA polymerase II subunit H
VGNC:21680
100059115
Cow
RNA polymerase II subunit H
VGNC:33142
505599
Pig
RNA polymerase II subunit H
100628241
Species
Name
OMA
EggNOG
Inparanoid
Macaque
RNA polymerase II subunit H
Mouse
Horse
RNA polymerase II subunit H
Cow
RNA polymerase II subunit H
Pig
RNA polymerase II subunit H
Publication Statistics
PubMed Score 22.46
PubMed score by year
PubTator Score 212.32
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title