Tbio POLR2H DNA-directed RNA polymerases I, II, and III subunit RPABC3

Protein Summary

Description

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. The three eukaryotic RNA polymerases are complex multisubunit enzymes that play a central role in the transcription of nuclear genes. This gene encodes an essential and highly conserved subunit of RNA polymerase II that is shared by the other two eukaryotic DNA-directed RNA polymerases, I and III. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

Uniprot Accession IDs

• P52434
• C9J413
• C9JBJ6
• C9JCU7
• C9JUA8
• P53802
• Q969R0
• RNA polymerases I, II, and III subunit ABC3

Gene Name

• POLR2H

Ensembl ID

• ENST00000429568
• ENSP00000415536
• ENSG00000163882
• ENST00000430783
• ENSP00000411883
• ENST00000438240
• ENSP00000398622
• ENST00000443489
• ENSP00000393773
• ENST00000452961
• ENSP00000399882
• ENST00000456318
• ENSP00000392913

Symbol

• RPB8
• RPB17
• RPABC3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	1
virus perturbation	0.99
interacting protein	0.98
biological process	0.87
disease perturbation	0.87

Protein Classes

PANTHER Classes

Protein / Transferase / Nucleotidyltransferase / Dna-directed Rna Polymerases I, Ii, And Iii Subunit Rpabc3

Protein / Nucleic Acid Binding / Rna Binding Protein / Dna-directed Rna Polymerase / Dna-directed Rna Polymerases I, Ii, And Iii Subunit Rpabc3

DTO Classes

Protein / Enzyme / Transferase / Nucleotidyltransferase / Polymerase / Dna-directed Rna Polymerase / Dna-directed Rna Polymerases I, Ii, And Iii Subunit Rpabc3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.41   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 226   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.41   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 226   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0