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Tclin
JAK3
Tyrosine-protein kinase JAK3

Protein Summary
Description
Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, upon IL2R activation by IL2, JAK1 and JAK3 molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000458235
  • ENSP00000391676
  • ENSG00000105639
  • ENST00000527670
  • ENSP00000432511
  • ENST00000534444
  • ENSP00000436421

Symbol
  • JAKL
  • LJAK
  • JAK-3
  • L-JAK
  • JAK3_HUMAN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
chemical bioactivity profile
1
protein domain
1
molecular function
0.97
hub protein
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 620.59   (req: < 5)
Gene RIFs: 129   (req: <= 3)
Antibodies: 416   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 620.59   (req: >= 5)
Gene RIFs: 129   (req: > 3)
Antibodies: 416   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 38
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1106
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 11
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (11)
nintedanib
Rendered image for nintedanib
ibrutinib
Rendered image for ibrutinib
midostaurin
Rendered image for midostaurin
fedratinib
Rendered image for fedratinib
acalabrutinib
Rendered image for acalabrutinib
baricitinib
Rendered image for baricitinib
ruxolitinib
Rendered image for ruxolitinib
tofacitinib
Rendered image for tofacitinib
upadacitinib
Rendered image for upadacitinib
filgotinib
Rendered image for filgotinib
Protein-Protein Interactions (263)
CDK4
Tclin
Family:  Kinase
Novelty:  0.00036742
p_int:  0.994890112
p_ni:  0.004997126
p_wrong:  0.000112762
Score:  0.46
Data Source:  BioPlex,STRINGDB
STAT5A
Tchem
Family:  TF
Novelty:  0.00074026
Score:  0.997
Data Source:  Reactome,STRINGDB
STAT5B
Tchem
Family:  TF
Novelty:  0.00074178
Score:  0.997
Data Source:  Reactome,STRINGDB
STAT3
Tchem
Family:  TF
Novelty:  0.00011808
Score:  0.994
Data Source:  Reactome,STRINGDB
STAT6
Tchem
Family:  TF
Novelty:  0.00096732
Score:  0.989
Data Source:  Reactome,STRINGDB
IL2RG
Tclin
Novelty:  0.00108272
Score:  0.989
Data Source:  Reactome,STRINGDB
STAT1
Tchem
Family:  TF
Novelty:  0.0003383
Score:  0.986
Data Source:  Reactome,STRINGDB
IL2
Tchem
Novelty:  0.00003129
Score:  0.981
Data Source:  Reactome,STRINGDB
STAM
Tbio
Novelty:  0.0332731
Score:  0.979
Data Source:  STRINGDB
SOCS1
Tbio
Novelty:  0.00131368
Score:  0.978
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (110)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
FLT3 Signaling
Reactome
Immune System
Reactome
Interleukin receptor SHC signaling
Reactome
Interleukin-15 signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
FLT3 Signaling
Immune System
Interleukin receptor SHC signaling
Interleukin-15 signaling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (42)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Disease Associations ()
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
1
1
1
83.1
reticulocyte measurement
2
3
3
78.4
4
3
4
76.7
reticulocyte count
1
2
2
68.4
cancer antigen 19.9 measurement
1
1
1
57.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
1
83.1
reticulocyte measurement
3
78.4
4
76.7
reticulocyte count
2
68.4
cancer antigen 19.9 measurement
1
57.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Janus kinase 3
VGNC:11234
748892
Macaque
Janus kinase 3
720040
Mouse
MGI:99928
16453
Rat
RGD:2940
25326
Dog
Janus kinase 3
VGNC:42177
610004
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Janus kinase 3
Macaque
Janus kinase 3
Mouse
Rat
Dog
Janus kinase 3
Publication Statistics
PubMed Score 620.59
PubMed score by year
PubTator Score 520.52
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title