RAP1GDS1
Rap1 GTPase-GDP dissociation stimulator 1
Protein Summary
Stimulates GDP/GTP exchange reaction of a group of small GTP-binding proteins (G proteins) including Rap1a/Rap1b, RhoA, RhoB and KRas, by stimulating the dissociation of GDP from and the subsequent binding of GTP to each small G protein. The smg GDP dissociation stimulator (smgGDS) protein is a stimulatory GDP/GTP exchange protein with GTPase activity (Riess et al., 1993 [PubMed 8262526]).[supplied by OMIM, Feb 2010]
- ENST00000264572
- ENSP00000264572
- ENSG00000138698
- ENST00000339360
- ENSP00000340454
- ENST00000380158
- ENSP00000369503
- ENST00000408900
- ENSP00000386223
- ENST00000408927
- ENSP00000386153
- ENST00000453712
- ENSP00000407157
- GDS1
- SmgGDS
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 0.93 | ||
kinase perturbation | 0.93 | ||
transcription factor perturbation | 0.91 | ||
histone modification site profile | 0.9 | ||
interacting protein | 0.86 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 31.04 (req: < 5)
Gene RIFs: 29 (req: <= 3)
Antibodies: 142 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 31.04 (req: >= 5)
Gene RIFs: 29 (req: > 3)
Antibodies: 142 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0