Pharos : Target Details

Tbio

Protein Summary

Description

Stimulates GDP/GTP exchange reaction of a group of small GTP-binding proteins (G proteins) including Rap1a/Rap1b, RhoA, RhoB and KRas, by stimulating the dissociation of GDP from and the subsequent binding of GTP to each small G protein. The smg GDP dissociation stimulator (smgGDS) protein is a stimulatory GDP/GTP exchange protein with GTPase activity (Riess et al., 1993 [PubMed 8262526]).[supplied by OMIM, Feb 2010]

Uniprot Accession IDs

Gene Name

RAP1GDS1

Ensembl ID

ENST00000264572
ENSP00000264572
ENSG00000138698
ENST00000339360
ENSP00000340454
ENST00000380158
ENSP00000369503
ENST00000408900
ENSP00000386223
ENST00000408927
ENSP00000386153
ENST00000453712
ENSP00000407157

Symbol

GDS1
SmgGDS

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.93

kinase perturbation	0.93

transcription factor perturbation	0.91

histone modification site profile	0.9

interacting protein	0.86

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.01 (req: < 5)

Gene RIFs: 24 (req: <= 3)

View Gene RIFs

Antibodies: 142 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.01 (req: >= 5)

Gene RIFs: 24 (req: > 3)

Antibodies: 142 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

View GO Terms

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Expression Data (0 Tissues)

No expression data found

Related Tools

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (102)

Explore Interacting Targets

1 – 10 of 102

See Interactions on String-DB

DIRAS1

Tbio

Family: Enzyme

Novelty: 0.13332903

p_int: 0.999999921

p_ni: 7.6e-8

p_wrong: 3e-9

Score: 0.683

Data Source: BioPlex,STRINGDB

UBTF

Tbio

Family: TF

Novelty: 0.00421069

p_int: 0.999999877

p_ni: 1.23e-7

Data Source: BioPlex

RAP1A

Tchem

Family: Enzyme

Novelty: 0.00375413

p_int: 0.999999609

p_ni: 3.2e-7

p_wrong: 7e-8

Score: 0.596

Data Source: BioPlex,STRINGDB

PLEKHB1

Tbio

Novelty: 0.0106759

p_int: 0.999998081

p_ni: 8.93e-7

p_wrong: 0.000001026

Score: 0.288

Data Source: BioPlex,STRINGDB

DIRAS2

Tbio

Family: Enzyme

Novelty: 0.12334631

p_int: 0.999995446

p_ni: 0.000004554

Score: 0.69

Data Source: BioPlex,STRINGDB

RAC3

Tbio

Family: Enzyme

Novelty: 0.02125361

p_int: 0.999944471

p_ni: 0.000049086

p_wrong: 0.000006443

Score: 0.748

Data Source: BioPlex,STRINGDB

RHOA

Tbio

Family: Enzyme

Novelty: 0.00022204

p_int: 0.999601735

p_ni: 0.000398265

Score: 0.966

Data Source: BioPlex,STRINGDB

PRDM10

Tbio

Family: TF; Epigenetic

Novelty: 0.03463517

p_int: 0.99941094

p_ni: 0.00058906

Data Source: BioPlex

RAP2C

Tbio

Family: Enzyme

Novelty: 0.08572837

p_int: 0.997722479

p_ni: 0.002277521

Score: 0.485

Data Source: BioPlex,STRINGDB

RAP1B

Tbio

Family: Enzyme

Novelty: 0.00627538

p_int: 0.99524063

p_ni: 0.00475937

Score: 0.604

Data Source: BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (2)

PathwayCommons (2)

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Items per page:

1 – 2 of 2

Data Source	Name	Explore in Pharos	Explore in Source
PathwayCommons: pid	Regulation of RAC1 activity	39 targets	PathwayCommons: pid

PathwayCommons: pid	Regulation of RhoA activity	48 targets	PathwayCommons: pid

Name	Explore in Pharos	Explore in Source
Regulation of RAC1 activity	39 targets	PathwayCommons: pid

Regulation of RhoA activity	48 targets	PathwayCommons: pid

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (10)

Functions (1)

Components (4)

Processes (5)

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Items per page:

1 – 1 of 1

GO Term	Evidence	Assigned by
GTPase activator activity	Non-traceable Author Statement (NAS)	UniProtKB

Disease Associations ()

No disease associations found

GWAS Traits (0)

No GWAS traits found

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UniProt Keyword

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No Header	No Header
3D-structure

Acetylation

Alternative splicing

Complete proteome

GTPase activation

Polymorphism

Reference proteome

Repeat

IDG Resources

No IDG generated resources found

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID
Chimp	Rap1 GTPase-GDP dissociation stimulator 1	VGNC:8270	461388

Macaque	Rap1 GTPase-GDP dissociation stimulator 1		706303

Mouse	RAP1, GTP-GDP dissociation stimulator 1	MGI:2385189	229877

Rat	Rap1 GTPase-GDP dissociation stimulator 1	RGD:1308558	310909

Dog	Rap1 GTPase-GDP dissociation stimulator 1	VGNC:45343	487868

Species	Name	OMA	EggNOG	Inparanoid
Chimp	Rap1 GTPase-GDP dissociation stimulator 1

Macaque	Rap1 GTPase-GDP dissociation stimulator 1

Mouse	RAP1, GTP-GDP dissociation stimulator 1

Rat	Rap1 GTPase-GDP dissociation stimulator 1

Dog	Rap1 GTPase-GDP dissociation stimulator 1

Publication Statistics

PubMed Score 19.01

PubMed score by year

PubTator Score 31.26

PubTator score by year

Related Publications

GeneRif Annotations (24)

Items per page:

0 of 0

PMID	Text