Tbio RAP1GDS1 Rap1 GTPase-GDP dissociation stimulator 1

Protein Summary

Description

Stimulates GDP/GTP exchange reaction of a group of small GTP-binding proteins (G proteins) including Rap1a/Rap1b, RhoA, RhoB and KRas, by stimulating the dissociation of GDP from and the subsequent binding of GTP to each small G protein. The smg GDP dissociation stimulator (smgGDS) protein is a stimulatory GDP/GTP exchange protein with GTPase activity (Riess et al., 1993 [PubMed 8262526]).[supplied by OMIM, Feb 2010]

Uniprot Accession IDs

• P52306
• E9PH06
• G5E9P9
• Q499L7
• Q4KMV2
• Q4QQI8
• Q9BUW9
• Q9BUX6
• Q9NYM2
• Q9NZA8

Gene Name

• RAP1GDS1

Ensembl ID

• ENST00000264572
• ENSP00000264572
• ENSG00000138698
• ENST00000339360
• ENSP00000340454
• ENST00000380158
• ENSP00000369503
• ENST00000408900
• ENSP00000386223
• ENST00000408927
• ENSP00000386153
• ENST00000453712
• ENSP00000407157

Symbol

• GDS1
• SmgGDS

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.93
kinase perturbation	0.93
transcription factor perturbation	0.91
histone modification site profile	0.9
interacting protein	0.86

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.04   (req: < 5)

Gene RIFs: 29   (req: <= 3)

Antibodies: 142   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.04   (req: >= 5)

Gene RIFs: 29   (req: > 3)

Antibodies: 142   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0