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Tbio
NCBP2
Nuclear cap-binding protein subunit 2

Protein Summary
Description
Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus via its interaction with ALYREF/THOC4/ALY, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC com ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000321256
  • ENSP00000326806
  • ENSG00000114503
  • ENST00000427641
  • ENSP00000397619
  • ENST00000452404
  • ENSP00000412785

Symbol
  • CBP20
  • CBC2
  • NIP1
  • CBP20
  • PIG55
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.94
transcription factor binding site profile
0.89
histone modification site profile
0.86
hub protein
0.75
pathway
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.69   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 162   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.69   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 162   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HIV-1 infection
1
1
1
61.5
viral load
1
1
1
61.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HIV-1 infection
1
61.5
viral load
1
61.5
Protein Data Bank (11)
1 – 5 of 11
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (60)
Abortive elongation of HIV-1 transcript in the absence of Tat (R-HSA-167242)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 56
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Abortive elongation of HIV-1 transcript in the absence of Tat
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
Disease
Reactome
Diseases of signal transduction
Name
Explore in Pharos
Explore in Source
Abortive elongation of HIV-1 transcript in the absence of Tat
Axon guidance
Developmental Biology
Disease
Diseases of signal transduction
Gene Ontology Terms (34)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (571)
1 – 10 of 571
SMG1
Tchem
Family: Kinase
Novelty: 0.00854339
Score: 0.999
Data Source: STRINGDB
RBM8A
Tbio
Novelty: 0.00052175
Score: 0.999
Data Source: STRINGDB
NCBP1
Tbio
Novelty: 0.01228885
Score: 0.999
Data Source: Reactome,STRINGDB
DDIT4L
Tbio
Novelty: 0.08748295
Score: 0.993
Data Source: STRINGDB
PHAX
Tbio
Novelty: 0.04027466
Score: 0.991
Data Source: Reactome,STRINGDB
SRRT
Tbio
Novelty: 0.00429818
Score: 0.99
Data Source: Reactome,STRINGDB
MTREX
Tbio
Novelty: 0.01358024
Score: 0.987
Data Source: STRINGDB
UPF1
Tbio
Novelty: 0.00311006
Score: 0.987
Data Source: STRINGDB
EIF4G1
Tbio
Novelty: 0.00170995
Score: 0.986
Data Source: Reactome,STRINGDB
SF3A2
Tbio
Novelty: 0.03658692
Score: 0.986
Data Source: STRINGDB
Publication Statistics
PubMed Score  67.69

PubMed score by year
PubTator Score  28.75

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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