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Tbio
KPNA1
Importin subunit alpha-5

Protein Summary
Description
Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. The transport of molecules between the nucleus and the cytoplasm i ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000344337
  • ENSP00000343701
  • ENSG00000114030

Symbol
  • RCH2
  • RCH2
  • SRP1
  • IPOA5
  • NPI-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.88
biological process
0.81
transcription factor perturbation
0.8
disease perturbation
0.79
transcription factor binding site profile
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 109.88   (req: < 5)
Gene RIFs: 32   (req: <= 3)
Antibodies: 361   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 109.88   (req: >= 5)
Gene RIFs: 32   (req: > 3)
Antibodies: 361   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
71.1
mathematical ability
1
1
1
63.6
mean corpuscular hemoglobin concentration
1
1
1
46.3
low density lipoprotein cholesterol measurement
2
2
2
30.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
71.1
mathematical ability
1
63.6
mean corpuscular hemoglobin concentration
1
46.3
low density lipoprotein cholesterol measurement
2
30.6
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
karyopherin subunit alpha 1
VGNC:1862
460631
Macaque
karyopherin subunit alpha 1
692082
Mouse
MGI:103560
16646
Rat
RGD:735064
288064
Dog
karyopherin subunit alpha 1
VGNC:42500
478585
Species
Name
OMA
EggNOG
Inparanoid
Chimp
karyopherin subunit alpha 1
Macaque
karyopherin subunit alpha 1
Mouse
Rat
Dog
karyopherin subunit alpha 1
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P52294-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (29)
Antiviral mechanism by IFN-stimulated genes (R-HSA-1169410)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 23
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antiviral mechanism by IFN-stimulated genes
Reactome
Apoptosis
Reactome
Apoptosis induced DNA fragmentation
Reactome
Apoptotic execution phase
Reactome
Cytokine Signaling in Immune system
Name
Explore in Pharos
Explore in Source
Antiviral mechanism by IFN-stimulated genes
Apoptosis
Apoptosis induced DNA fragmentation
Apoptotic execution phase
Cytokine Signaling in Immune system
Protein-Protein Interactions (120)
1 – 10 of 120
RNMT
Tbio
Family: Enzyme
Novelty: 0.00880207
p_int: 0.945766018
p_ni: 0.054233982
Score: 0.518
Data Source: BioPlex,STRINGDB
NOP56
Tbio
Novelty: 0.01256937
p_int: 0.928749298
p_ni: 0.071250702
Score: 0.524
Data Source: BioPlex,STRINGDB
SREK1IP1
Tdark
Novelty: 1.39429464
p_int: 0.781360148
p_ni: 0.218639852
Score: 0.238
Data Source: BioPlex,STRINGDB
NUP50
Tbio
Novelty: 0.03424725
p_int: 0.753334707
p_ni: 0.246665293
Score: 0.958
Data Source: BioPlex,STRINGDB
KPNB1
Tbio
Novelty: 0.01469696
Score: 0.996
Data Source: Reactome,STRINGDB
RAN
Tbio
Family: Enzyme
Novelty: 0.00160888
Score: 0.978
Data Source: STRINGDB
TPX2
Tbio
Novelty: 0.00435921
Score: 0.957
Data Source: STRINGDB
CDKN1B
Tbio
Family: Enzyme
Novelty: 0.00069449
Score: 0.933
Data Source: STRINGDB
RCC1
Tbio
Novelty: 0.00260884
Score: 0.921
Data Source: STRINGDB
CSE1L
Tbio
Novelty: 0.00748892
Score: 0.915
Data Source: STRINGDB
Publication Statistics
PubMed Score  109.88

PubMed score by year
PubTator Score  66.37

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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