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Tchem
PGD
6-phosphogluconate dehydrogenase, decarboxylating

Protein Summary
Description
Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. 6-phosphogluconate dehydrogenase is the second dehydrogenase in the pentose phosphate shunt. Deficiency of this enzyme is generally asymptomatic, and the inheritance of this disorder is autosomal dominant. Hemolysis results from combined deficiency of 6-phosphogluconate dehydrogenase and 6-phosphogluconolactonase suggesting a synergism of the two enzymopathies. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000270776
  • ENSP00000270776
  • ENSG00000142657

Symbol
  • PGDH
  • 6PGD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
transcription factor perturbation
0.94
interacting protein
0.93
disease perturbation
0.87
transcription factor binding site profile
0.83


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 157.81   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 300   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 157.81   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 300   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
1
1
1
17.9
hemoglobin measurement
1
1
1
2.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
1
17.9
hemoglobin measurement
1
2.1
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphogluconate dehydrogenase
VGNC:1449
100612990
Mouse
MGI:97553
110208
Dog
phosphogluconate dehydrogenase
VGNC:44456
478236
Horse
phosphogluconate dehydrogenase
VGNC:21352
100146298
Cow
phosphogluconate dehydrogenase
VGNC:32786
514939
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphogluconate dehydrogenase
Mouse
Dog
phosphogluconate dehydrogenase
Horse
phosphogluconate dehydrogenase
Cow
phosphogluconate dehydrogenase
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P52209-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (16)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Reactome
Pentose phosphate pathway
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of carbohydrates
Pentose phosphate pathway
Protein-Protein Interactions (170)
1 – 10 of 170
H6PD
Tbio
Novelty: 0.00366637
Score: 0.998
Data Source: STRINGDB
PGLS
Tbio
Family: Enzyme
Novelty: 0.03252394
Score: 0.997
Data Source: STRINGDB
IDNK
Tbio
Family: Kinase
Novelty: 0.07579524
Score: 0.997
Data Source: STRINGDB
G6PD
Tchem
Family: Enzyme
Novelty: 0.00064455
Score: 0.993
Data Source: STRINGDB
TALDO1
Tbio
Family: Enzyme
Novelty: 0.00208619
Score: 0.993
Data Source: STRINGDB
RPIA
Tbio
Family: Enzyme
Novelty: 0.00968705
Score: 0.988
Data Source: STRINGDB
RPE
Tbio
Family: Enzyme
Novelty: 0.01035554
Score: 0.978
Data Source: STRINGDB
RPEL1
Tbio
Family: Enzyme
Novelty: 0.40871656
Score: 0.961
Data Source: STRINGDB
TKT
Tchem
Family: Enzyme
Novelty: 0.00333936
Score: 0.95
Data Source: STRINGDB
GPI
Tbio
Family: Enzyme
Novelty: 0.00095404
Score: 0.943
Data Source: STRINGDB
Publication Statistics
PubMed Score  157.81

PubMed score by year
PubTator Score  151.32

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer