RND2
Rho-related GTP-binding protein RhoN
Protein Summary
May be specifically involved in neuronal and hepatic functions. Is a C3 toxin-insensitive member of the Rho subfamily (By similarity). This gene encodes a member of the Rho GTPase family, whose members play a key role in the regulation of actin cytoskeleton organization in response to extracellular growth factors. This particular family member has been implicated in the regulation of neuronal morphology and endosomal trafficking. The gene localizes to chromosome 17 and is the centromeric neighbor of the breast-ovarian cancer susceptibility gene BRCA1. [provided by RefSeq, Jul 2008]
- ENST00000587250
- ENSP00000466680
- ENSG00000108830
- ARHN
- RHO7
- ARHN
- RHO7
- RhoN
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.93 | ||
virus perturbation | 0.76 | ||
transcription factor binding site profile | 0.71 | ||
PubMedID | 0.68 | ||
histone modification site profile | 0.64 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 79.78 (req: < 5)
Gene RIFs: 5 (req: <= 3)
Antibodies: 104 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 79.78 (req: >= 5)
Gene RIFs: 5 (req: > 3)
Antibodies: 104 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 13
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0