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Tchem
FUT6
Alpha-(1,3)-fucosyltransferase 6

Protein Summary
Description
Enzyme involved in the biosynthesis of the E-Selectin ligand, sialyl-Lewis X. Catalyzes the transfer of fucose from GDP-beta-fucose to alpha-2,3 sialylated substrates. The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of sialyl-Lewis X, an E-selectin ligand. Mutations in this gene are a cause of fucosyltransferase-6 deficiency. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000286955
  • ENSP00000286955
  • ENSG00000156413
  • ENST00000318336
  • ENSP00000313398
  • ENST00000524754
  • ENSP00000431708
  • ENST00000527106
  • ENSP00000432954
  • ENST00000592563
  • ENSP00000466016

Symbol
  • FCT3A
  • FT1A
  • FCT3A
  • Fuc-TVI
  • FucT-VI
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.95
cell type or tissue
0.81
cellular component
0.7
cell line
0.54
small molecule perturbation
0.53


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.48   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 232   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.48   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 232   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cancer biomarker measurement
1
3
4
96.3
vitamin B12 measurement
2
3
2
49.8
95.4
N-glycan measurement
2
1
18
92
1
1
0
1.4
74.7
atrophic macular degeneration
1
1
0
1.4
74.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cancer biomarker measurement
4
96.3
vitamin B12 measurement
2
49.8
95.4
N-glycan measurement
18
92
0
1.4
74.7
atrophic macular degeneration
0
1.4
74.7
Pathways (7)
Blood group systems biosynthesis (R-HSA-9033658)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Blood group systems biosynthesis
Reactome
Lewis blood group biosynthesis
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Name
Explore in Pharos
Explore in Source
Blood group systems biosynthesis
Lewis blood group biosynthesis
Metabolism
Metabolism of carbohydrates
Protein-Protein Interactions (64)
1 – 10 of 64
FUT1
Tbio
Family: Enzyme
Novelty: 0.00597206
Score: 0.974
Data Source: STRINGDB
FUT2
Tbio
Family: Enzyme
Novelty: 0.0009286
Score: 0.971
Data Source: STRINGDB
B4GALT1
Tbio
Family: Enzyme
Novelty: 0.0073693
Score: 0.967
Data Source: STRINGDB
ST3GAL6
Tbio
Family: Enzyme
Novelty: 0.05226811
Score: 0.954
Data Source: STRINGDB
ST8SIA1
Tbio
Family: Enzyme
Novelty: 0.02322808
Score: 0.949
Data Source: STRINGDB
B4GALT2
Tbio
Family: Enzyme
Novelty: 0.03492512
Score: 0.944
Data Source: STRINGDB
B3GNT3
Tbio
Family: Enzyme
Novelty: 0.04325325
Score: 0.943
Data Source: STRINGDB
B4GALT3
Tbio
Family: Enzyme
Novelty: 0.04015046
Score: 0.937
Data Source: STRINGDB
B4GALT4
Tbio
Family: Enzyme
Novelty: 0.11226614
Score: 0.932
Data Source: STRINGDB
B3GNT4
Tbio
Family: Enzyme
Novelty: 0.47935258
Score: 0.924
Data Source: STRINGDB
Publication Statistics
PubMed Score  74.48

PubMed score by year
PubTator Score  48.7

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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