You are using an outdated browser. Please upgrade your browser to improve your experience.

Tclin
NDUFA8
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8

Protein Summary
Description
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. The protein encoded by this gene belongs to the complex I 19 kDa subunit family. Mammalian complex I is composed of 45 different subunits. This protein has NADH dehydrogenase activity and oxidoreductase activity. It plays an important role in transfering electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373768
  • ENSP00000362873
  • ENSG00000119421

Symbol
  • PGIV
  • CI-19KD
  • CI-PGIV
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
kinase perturbation
0.97
virus perturbation
0.88
gene perturbation
0.81
interacting protein
0.79


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.92   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 200   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.92   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 200   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
metformin
chemical structure image
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NADH:ubiquinone oxidoreductase subunit A8
VGNC:4799
464897
Mouse
MGI:1915625
68375
Rat
RGD:1306283
296658
Dog
NADH:ubiquinone oxidoreductase subunit A8
VGNC:43690
480741
Horse
NADH:ubiquinone oxidoreductase subunit A8
VGNC:20627
100067562
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NADH:ubiquinone oxidoreductase subunit A8
Mouse
Rat
Dog
NADH:ubiquinone oxidoreductase subunit A8
Horse
NADH:ubiquinone oxidoreductase subunit A8
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P51970-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (17)
Complex I biogenesis (R-HSA-6799198)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Complex I biogenesis
Reactome
Metabolism
Reactome
Respiratory electron transport
Reactome
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Reactome
The citric acid (TCA) cycle and respiratory electron transport
Name
Explore in Pharos
Explore in Source
Complex I biogenesis
Metabolism
Respiratory electron transport
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
The citric acid (TCA) cycle and respiratory electron transport
Protein-Protein Interactions (175)
1 – 10 of 175
NDUFA12
Tclin
Family: Enzyme
Novelty: 0.04679316
p_int: 0.999995528
p_ni: 0.000004472
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFS4
Tclin
Family: Enzyme
Novelty: 0.00787292
p_int: 0.999986166
p_ni: 0.000013825
p_wrong: 9e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
MT-ND4
Tclin
Family: Enzyme
Novelty: 0.00079935
p_int: 0.999965792
p_ni: 0.000031942
p_wrong: 0.000002266
Score: 0.998
Data Source: BioPlex,STRINGDB
MT-ND5
Tclin
Family: Enzyme
Novelty: 0.00223164
p_int: 0.999937941
p_ni: 0.000062058
Score: 0.997
Data Source: BioPlex,STRINGDB
NDUFB8
Tclin
Family: Enzyme
Novelty: 0.019021
p_int: 0.999899915
p_ni: 0.000100084
p_wrong: 1e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFA7
Tclin
Family: Enzyme
Novelty: 0.16417588
p_int: 0.99986353
p_ni: 0.00013647
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFB7
Tclin
Family: Enzyme
Novelty: 0.14580093
p_int: 0.99971111
p_ni: 0.000273753
p_wrong: 0.000015137
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFB9
Tclin
Family: Enzyme
Novelty: 0.00715628
p_int: 0.99967634
p_ni: 0.000323613
p_wrong: 4.7e-8
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFB5
Tclin
Family: Enzyme
Novelty: 0.0257403
p_int: 0.999583361
p_ni: 0.000416639
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFB6
Tclin
Family: Enzyme
Novelty: 0.075245
p_int: 0.999514442
p_ni: 0.000482862
p_wrong: 0.000002696
Score: 0.999
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  14.92

PubMed score by year
PubTator Score  2.23

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer