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Tbio
CCNG1
Cyclin-G1

Protein Summary
Description
May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation (By similarity). The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The protein encoded by this gene is a member of the cyclin family and contains the cyclin box. The encoded protein lacks the protein destabilizing (PEST) sequence that is present in other family members. Transcriptional activation of this gene can be induced by tumor protein p53. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340828
  • ENSP00000344635
  • ENSG00000113328
  • ENST00000393929
  • ENSP00000377506
  • ENST00000512163
  • ENSP00000424315

Symbol
  • CCNG
  • CYCG1
  • CCNG
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
transcription factor perturbation
0.99
disease perturbation
0.96
transcription factor binding site profile
0.78
PubMedID
0.74


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 121.14   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 278   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 121.14   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 278   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cyclin G1
VGNC:3936
462243
Macaque
cyclin G1
697738
Mouse
MGI:102890
12450
Rat
RGD:2295
25405
Dog
cyclin G1
VGNC:38900
479303
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cyclin G1
Macaque
cyclin G1
Mouse
Rat
Dog
cyclin G1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P51959-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (14)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
Regulation of TP53 Activity
Reactome
Regulation of TP53 Degradation
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
Regulation of TP53 Activity
Regulation of TP53 Degradation
Protein-Protein Interactions (115)
1 – 10 of 115
CPSF4L
Tdark
Novelty: 4.27116708
p_int: 0.999991261
p_ni: 7.2e-8
p_wrong: 0.000008667
Score: 0.218
Data Source: BioPlex,STRINGDB
PPP2R5D
Tbio
Family: Enzyme
Novelty: 0.03990599
p_int: 0.994294237
p_ni: 0.005705762
Score: 0.388
Data Source: BioPlex,STRINGDB
PPP2R5E
Tbio
Family: Enzyme
Novelty: 0.05974697
p_int: 0.992336295
p_ni: 0.007663705
Score: 0.376
Data Source: BioPlex,STRINGDB
ZZEF1
Tdark
Novelty: 0.33216648
p_int: 0.976119544
p_ni: 0.023880456
Score: 0.152
Data Source: BioPlex,STRINGDB
CUL4A
Tbio
Novelty: 0.00917788
p_int: 0.952972969
p_ni: 0.047027031
Score: 0.322
Data Source: BioPlex,STRINGDB
CUL4B
Tbio
Novelty: 0.0133075
p_int: 0.942702166
p_ni: 0.057297834
Score: 0.305
Data Source: BioPlex,STRINGDB
PPP2R5C
Tbio
Family: Enzyme
Novelty: 0.03336609
p_int: 0.913241692
p_ni: 0.086758308
Score: 0.948
Data Source: BioPlex,Reactome,STRINGDB
DDB1
Tbio
Novelty: 0.00345896
p_int: 0.889867908
p_ni: 0.110132092
Score: 0.232
Data Source: BioPlex,STRINGDB
UBR4
Tbio
Family: Enzyme
Novelty: 0.03924839
p_int: 0.797159288
p_ni: 0.202840712
Data Source: BioPlex
TP53
Tchem
Family: TF
Novelty: 0.00001907
Score: 0.994
Data Source: STRINGDB
Publication Statistics
PubMed Score  121.14

PubMed score by year
PubTator Score  80.09

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer