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Tchem
NEK3
Serine/threonine-protein kinase Nek3

Protein Summary
Description
Protein kinase which influences neuronal morphogenesis and polarity through effects on microtubules. Regulates microtubule acetylation in neurons. Contributes to prolactin-mediated phosphorylation of PXN and VAV2. Implicated in prolactin-mediated cytoskeletal reorganization and motility of breast cancer cells through mechanisms involving RAC1 activation and phosphorylation of PXN and VAV2. This gene encodes a member of the NimA (never in mitosis A) family of serine/threonine protein kinases. The encoded protein differs from other NimA family members in that it is not cell cycle regulated and is found primarily in the cytoplasm. The kinase is activated by prolactin stimulation, leading to phosphorylation of VAV2 guanine nucleotide exchange factor, paxillin, and activation of the RAC1 GTPase. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000610828
  • ENSP00000480328
  • ENSG00000136098
  • ENST00000611833
  • ENSP00000484086
  • ENST00000618534
  • ENSP00000484443

Symbol
  • HSPK36
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.94
drug perturbation
0.87
histone modification site profile
0.76
kinase perturbation
0.76
protein domain
0.73


Related Tools
Dark Kinase Knowledgebase
Thumbnail image for Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.13   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 223   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.13   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 223   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
IDG Resources
NanoBRET
image for NanoLuc®-NEK3
  • Institute:  UNC-CH
  • Authors:  Julie Pickett
  • PI:  Tim Willson
  • Assay ID:  BAO_0010069
  • Endpoint:  fold change
  • Endpoint Detection:  fluorescence intensity
  • Repository:  Synapse
NanoBRET
image for NanoLuc®-fused NEK3
Active Ligands (1)
1 – 1 of 1
SID103905151
Rendered image for SID103905151
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
anti-chlamydia trachomatis antibody measurement
1
1
0
1.3
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
anti-chlamydia trachomatis antibody measurement
0
1.3
15.8
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
NIMA related kinase 3
710127
Mouse
MGI:1344371
23954
Rat
RGD:1307419
306576
Horse
NIMA related kinase 3
VGNC:20670
100052419
Cow
NIMA related kinase 3
VGNC:31994
505876
Species
Name
OMA
EggNOG
Inparanoid
Macaque
NIMA related kinase 3
Mouse
Rat
Horse
NIMA related kinase 3
Cow
NIMA related kinase 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P51956-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (12)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (26)
1 – 10 of 26
CDK13
Tchem
Family:  Kinase
Novelty:  0.03084808
p_int:  0.999965741
p_ni:  0.000034259
Score:  0.266
Data Source:  BioPlex,STRINGDB
TNFSF8
Tbio
Novelty:  0.01292216
p_int:  0.999864626
p_ni:  0.000044569
p_wrong:  0.000090805
Score:  0.173
Data Source:  BioPlex,STRINGDB
CPNE2
Tdark
Novelty:  0.24188419
p_int:  0.989442508
p_ni:  0.000053651
p_wrong:  0.01050384
Score:  0.169
Data Source:  BioPlex,STRINGDB
VSIG4
Tbio
Novelty:  0.01671671
p_int:  0.750920955
p_ni:  0.002581455
p_wrong:  0.246497591
Score:  0.169
Data Source:  BioPlex,STRINGDB
TPTE
Tbio
Family:  Enzyme
Novelty:  0.0311793
Score:  0.75
Data Source:  STRINGDB
FGL1
Tbio
Novelty:  0.02650803
Score:  0.69
Data Source:  STRINGDB
RCC1L
Tbio
Novelty:  0.03545003
Score:  0.681
Data Source:  STRINGDB
VAV2
Tbio
Novelty:  0.01062502
Score:  0.655
Data Source:  STRINGDB
PRLR
Tbio
Novelty:  0.00161982
Score:  0.642
Data Source:  STRINGDB
CKAP2
Tbio
Novelty:  0.00345027
Score:  0.595
Data Source:  STRINGDB
Publication Statistics
PubMed Score  11.13

PubMed score by year
PubTator Score  9.75

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer