Tbio MNAT1 CDK-activating kinase assembly factor MAT1

Protein Summary

Description

Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. The protein encoded by this gene, along with cyclin H and CDK7, forms the CDK-activating kinase (CAK) enzymatic complex. This complex activates several cyclin-associated kinases and can also associate with TFIIH to activate transcription by RNA polymerase II. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

Uniprot Accession IDs

• P51948
• G3V1U8
• Q15817
• Q6ICQ7

Gene Name

• MNAT1

Ensembl ID

• ENST00000261245
• ENSP00000261245
• ENSG00000020426
• ENST00000539616
• ENSP00000446437

Symbol

• CAP35
• MAT1
• RNF66
• MAT1
• TFB3
• CAP35
• RNF66

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.98
disease perturbation	0.97
transcription factor binding site profile	0.89
drug perturbation	0.87
protein domain	0.85

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Cdk-activating Kinase Assembly Factor Mat1

Protein / Enzyme Modulator / Kinase Modulator / Kinase Activator / Cdk-activating Kinase Assembly Factor Mat1

DTO Classes

Protein / Enzyme Modulator / Kinase Modulator / Kinase Activator / Cdk-activating Kinase Assembly Factor Mat1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.3   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 221   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.3   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 221   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

ProtVista Viewer

Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

Go To Tool

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (279)

Explore Interacting Targets

1 – 10 of 279

• See Interactions on String-DB

CCNH

Tbio

Novelty:  0.00693072

p_int:  1

Score:  0.999

Data Source:  BioPlex,Reactome,STRINGDB

CDK7

Tchem

Family:  Kinase

Novelty:  0.00322814

p_int:  0.999999996

p_ni:  4e-9

Score:  0.999

Data Source:  BioPlex,Reactome,STRINGDB

PI15

Tbio

Family:  Enzyme

Novelty:  0.02244161

p_int:  0.988625489

p_ni:  0.01137451

Data Source:  BioPlex

CNOT3

Tbio

Novelty:  0.02463568

p_int:  0.974409045

p_ni:  0.025590852

p_wrong:  1.03e-7

Data Source:  BioPlex

ERCC3

Tbio

Family:  Enzyme

Novelty:  0.00978601

p_int:  0.932155265

p_ni:  0.067844735

Score:  0.999

Data Source:  BioPlex,STRINGDB

ABLIM3

Tdark

Novelty:  0.28184092

p_int:  0.916421747

p_ni:  0.083574632

p_wrong:  0.00000362

Data Source:  BioPlex

SIRT6

Tchem

Family:  Epigenetic

Novelty:  0.00155366

p_int:  0.826807501

p_ni:  0.173192499

Score:  0.161

Data Source:  BioPlex,STRINGDB

ERCC2

Tchem

Family:  Enzyme

Novelty:  0.00240155

p_int:  0.823269031

p_ni:  0.176730969

Score:  0.999

Data Source:  BioPlex,STRINGDB

GTF2H3

Tbio

Novelty:  0.08168167

Score:  0.999

Data Source:  STRINGDB

GTF2H4

Tbio

Novelty:  0.03140561

Score:  0.999

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (77)

Reactome (60)

KEGG (2)

PathwayCommons (7)

WikiPathways (8)

Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Find Similar Targets

Items per page:

5

1 – 5 of 60

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cell Cycle	597 targets	R-HSA-1640170
Reactome	Cell Cycle, Mitotic	495 targets	R-HSA-69278
Reactome	Cyclin A/B1/B2 associated events during G2/M transition	25 targets	R-HSA-69273
Reactome	Cyclin A:Cdk2-associated events at S phase entry	86 targets	R-HSA-69656
Reactome	Cyclin D associated events in G1	45 targets	R-HSA-69231

Name	Explore in Pharos	Explore in Source
Cell Cycle	597 targets	R-HSA-1640170
Cell Cycle, Mitotic	495 targets	R-HSA-69278
Cyclin A/B1/B2 associated events during G2/M transition	25 targets	R-HSA-69273
Cyclin A:Cdk2-associated events at S phase entry	86 targets	R-HSA-69656
Cyclin D associated events in G1	45 targets	R-HSA-69231

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (29)

Functions (3)

Components (4)

Processes (22)

Find Similar Targets

Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
protein N-terminus binding	Inferred from Physical Interaction (IPI)	UniProtKB
zinc ion binding	Traceable Author Statement (TAS)	ProtInc
cyclin-dependent protein serine/threonine kinase activator activity	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations (null)

No disease associations found

GWAS Traits (7)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 7

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
body height	EFO_0004339	1	2	2		88.5
appendicular lean mass	EFO_0004980	3	2	3		85.2
optic disc area measurement	EFO_0006937	1	1	1		53.7
type II diabetes mellitus	EFO_0001360	1	1	1		35
prostate carcinoma	EFO_0001663	1	1	0	1.1	33.1

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 7

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
body height	EFO_0004339	2		88.5
appendicular lean mass	EFO_0004980	3		85.2
optic disc area measurement	EFO_0006937	1		53.7
type II diabetes mellitus	EFO_0001360	1		35
prostate carcinoma	EFO_0001663	0	1.1	33.1

Reset Zoom  Beta Count   Odds Ratio

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Alternative splicing
Cell cycle
Complete proteome
Direct protein sequencing
Metal-binding
Nucleus
Phosphoprotein
Polymorphism

GWAS Trait Find Similar Targets

No Header	No Header
appendicular lean mass
BMI-adjusted hip circumference
body height
heel bone mineral density
optic disc area measurement
prostate carcinoma
type II diabetes mellitus

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
embryo phenotype
growth/size/body region phenotype
mortality/aging
nervous system phenotype
reproductive system phenotype

IDG Resources

No IDG generated resources found

Orthologs (17)

1 – 5 of 17

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	MNAT1, CDK activating kinase assembly factor	VGNC:8356	452954
Macaque	MNAT1, CDK activating kinase assembly factor		703905
Mouse	menage a trois 1	MGI:106207	17420
Rat	MNAT1, CDK activating kinase assembly factor	RGD:628874	266713
Dog	MNAT1, CDK activating kinase assembly factor	VGNC:43295	480346

Species	Name	OMA	EggNOG	Inparanoid
Chimp	MNAT1, CDK activating kinase assembly factor
Macaque	MNAT1, CDK activating kinase assembly factor
Mouse	menage a trois 1
Rat	MNAT1, CDK activating kinase assembly factor
Dog	MNAT1, CDK activating kinase assembly factor

Publication Statistics

PubMed Score 47.30

PubMed score by year

Reset Zoom

PubTator Score 31.65

PubTator score by year

Reset Zoom

Related Publications

Text Mined References (77)

GeneRif Annotations (13)

Items per page:

10

0 of 0

PMID	Year	Title