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Tbio
CCNH
Cyclin-H

Protein Summary
Description
Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle. The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000256897
  • ENSP00000256897
  • ENSG00000134480

Symbol
  • CAK
  • p34
  • p37
  • CycH
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.95
biological process
0.93
molecular function
0.88
ligand (protein) perturbation
0.83
virus perturbation
0.83


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 126.07   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 479   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 126.07   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 479   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
1
1
1
69.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
1
69.5
Orthologs (17)
1 – 5 of 17
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cyclin H
VGNC:11871
739351
Macaque
cyclin H
694224
Mouse
MGI:1913921
66671
Rat
RGD:69419
84389
Dog
cyclin H
VGNC:38902
479156
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cyclin H
Macaque
cyclin H
Mouse
Rat
Dog
cyclin H
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (73)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 60
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Cyclin A/B1/B2 associated events during G2/M transition
Reactome
Cyclin A:Cdk2-associated events at S phase entry
Reactome
Cyclin D associated events in G1
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
Cyclin A/B1/B2 associated events during G2/M transition
Cyclin A:Cdk2-associated events at S phase entry
Cyclin D associated events in G1
Protein-Protein Interactions (277)
1 – 10 of 277
CDK7
Tchem
Family: Kinase
Novelty: 0.00322814
p_int: 1
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
MNAT1
Tbio
Family: Enzyme
Novelty: 0.02484936
p_int: 1
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
ERCC3
Tbio
Family: Enzyme
Novelty: 0.00978601
p_int: 0.999999423
p_ni: 5.77e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
CDK2
Tchem
Family: Kinase
Novelty: 0.00032118
p_int: 0.999927499
p_ni: 0.000072501
Score: 0.986
Data Source: BioPlex,Reactome,STRINGDB
PI15
Tbio
Family: Enzyme
Novelty: 0.02244161
p_int: 0.999915859
p_ni: 0.000084013
p_wrong: 1.28e-7
Data Source: BioPlex
ERCC5
Tchem
Family: Enzyme
Novelty: 0.00819696
p_int: 0.999677744
p_ni: 2.25e-7
p_wrong: 0.000322031
Score: 0.99
Data Source: BioPlex,STRINGDB
ABLIM3
Tdark
Novelty: 0.28184092
p_int: 0.998359206
p_ni: 0.001640746
p_wrong: 4.8e-8
Data Source: BioPlex
CNOT3
Tbio
Novelty: 0.02463568
p_int: 0.998219925
p_ni: 0.001779077
p_wrong: 9.99e-7
Score: 0.217
Data Source: BioPlex,STRINGDB
ERCC2
Tbio
Family: Enzyme
Novelty: 0.00240155
p_int: 0.992986513
p_ni: 0.007013487
Score: 0.999
Data Source: BioPlex,STRINGDB
CPSF4L
Tdark
Novelty: 4.27116708
p_int: 0.984199103
p_ni: 0.015745044
p_wrong: 0.000055853
Score: 0.265
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  126.07

PubMed score by year
PubTator Score  78.35

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer