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Tbio
PRELP
Prolargin

Protein Summary
Description
May anchor basement membranes to the underlying connective tissue. The protein encoded by this gene is a leucine-rich repeat protein present in connective tissue extracellular matrix. This protein functions as a molecule anchoring basement membranes to the underlying connective tissue. This protein has been shown to bind type I collagen to basement membranes and type II collagen to cartilage. It also binds the basement membrane heparan sulfate proteoglycan perlecan. This protein is suggested to be involved in the pathogenesis of Hutchinson-Gilford progeria (HGP), which is reported to lack the binding of collagen in basement membranes and cartilage. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000343110
  • ENSP00000343924
  • ENSG00000188783

Symbol
  • SLRR2A
  • MST161
  • SLRR2A
  • MSTP161
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
pathway
0.93
microRNA
0.64
cellular component
0.61
virus perturbation
0.59
kinase perturbation
0.54


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.76   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 140   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.76   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 140   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
proline and arginine rich end leucine rich repeat protein
VGNC:11799
469649
Macaque
proline and arginine rich end leucine rich repeat protein
702702
Mouse
MGI:2151110
116847
Rat
RGD:620226
84400
Dog
proline and arginine rich end leucine rich repeat protein
VGNC:44959
488561
Species
Name
OMA
EggNOG
Inparanoid
Chimp
proline and arginine rich end leucine rich repeat protein
Macaque
proline and arginine rich end leucine rich repeat protein
Mouse
Rat
Dog
proline and arginine rich end leucine rich repeat protein
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P51888-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (12)
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) (R-HSA-3656244)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
Reactome
Defective CHST6 causes MCDC1
Reactome
Defective ST3GAL3 causes MCT12 and EIEE15
Reactome
Disease
Reactome
Diseases associated with glycosaminoglycan metabolism
Name
Explore in Pharos
Explore in Source
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
Defective CHST6 causes MCDC1
Defective ST3GAL3 causes MCT12 and EIEE15
Disease
Diseases associated with glycosaminoglycan metabolism
Protein-Protein Interactions (66)
1 – 10 of 66
TRIM68
Tbio
Family: Enzyme
Novelty: 0.11729189
p_int: 0.999999108
p_ni: 8.92e-7
Score: 0.182
Data Source: BioPlex,STRINGDB
CKAP4
Tbio
Novelty: 0.02104039
p_int: 0.999415611
p_ni: 0.000584389
Score: 0.179
Data Source: BioPlex,STRINGDB
DHRS4
Tbio
Family: Enzyme
Novelty: 0.02992279
p_int: 0.958927882
p_ni: 0.040660095
p_wrong: 0.000412023
Score: 0.17
Data Source: BioPlex,STRINGDB
COL14A1
Tbio
Novelty: 0.01760399
p_int: 0.882846523
p_ni: 0.117153461
p_wrong: 1.6e-8
Score: 0.33
Data Source: BioPlex,STRINGDB
AMD1
Tchem
Family: Enzyme
Novelty: 0.00231813
p_int: 0.846128095
p_ni: 0.153871721
p_wrong: 1.84e-7
Score: 0.181
Data Source: BioPlex,STRINGDB
FSTL1
Tbio
Novelty: 0.00557848
p_int: 0.845146652
p_ni: 0.131251116
p_wrong: 0.023602232
Score: 0.173
Data Source: BioPlex,STRINGDB
B4GALT3
Tbio
Family: Enzyme
Novelty: 0.04015046
Score: 0.973
Data Source: STRINGDB
B4GALT2
Tbio
Family: Enzyme
Novelty: 0.03492512
Score: 0.973
Data Source: STRINGDB
ACAN
Tbio
Novelty: 0.00033695
Score: 0.954
Data Source: STRINGDB
OGN
Tbio
Novelty: 0.00097407
Score: 0.935
Data Source: STRINGDB
Publication Statistics
PubMed Score  39.76

PubMed score by year
PubTator Score  23.02

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer