Tbio LUM Lumican

Protein Summary

Description

This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family that includes decorin, biglycan, fibromodulin, keratocan, epiphycan, and osteoglycin. In these bifunctional molecules, the protein moiety binds collagen fibrils and the highly charged hydrophilic glycosaminoglycans regulate interfibrillar spacings. Lumican is the major keratan sulfate proteoglycan of the cornea but is also distributed in interstitial collagenous matrices throughout the body. Lumican may regulate collagen fibril organization and circumferential growth, corneal transparency, and epithelial cell migration and tissue repair. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P51884
• B2R6R5
• Q96QM7

Gene Name

• LUM

Ensembl ID

• ENST00000266718
• ENSP00000266718
• ENSG00000139329

Symbol

• LDC
• SLRR2D
• LDC
• SLRR2D

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
pathway	0.95
disease perturbation	0.93
biological process	0.74
small molecule perturbation	0.71
gene perturbation	0.68

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 653.89   (req: < 5)

Gene RIFs: 67   (req: <= 3)

Antibodies: 328   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 653.89   (req: >= 5)

Gene RIFs: 67   (req: > 3)

Antibodies: 328   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0