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Tbio
LUM
Lumican

Protein Summary
Description
This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family that includes decorin, biglycan, fibromodulin, keratocan, epiphycan, and osteoglycin. In these bifunctional molecules, the protein moiety binds collagen fibrils and the highly charged hydrophilic glycosaminoglycans regulate interfibrillar spacings. Lumican is the major keratan sulfate proteoglycan of the cornea but is also distributed in interstitial collagenous matrices throughout the body. Lumican may regulate collagen fibril organization and circumferential growth, corneal transparency, and epithelial cell migration and tissue repair. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000266718
  • ENSP00000266718
  • ENSG00000139329

Symbol
  • LDC
  • SLRR2D
  • LDC
  • SLRR2D
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
pathway
0.95
disease perturbation
0.93
biological process
0.74
small molecule perturbation
0.71
gene perturbation
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 464.27   (req: < 5)
Gene RIFs: 67   (req: <= 3)
Antibodies: 328   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 464.27   (req: >= 5)
Gene RIFs: 67   (req: > 3)
Antibodies: 328   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
central corneal thickness
2
1
0
3
17.1
intraocular pressure measurement
1
1
1
2.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
central corneal thickness
0
3
17.1
intraocular pressure measurement
1
2.4
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lumican
VGNC:5464
452119
Macaque
lumican
709830
Mouse
MGI:109347
17022
Rat
RGD:620984
81682
Dog
lumican
VGNC:42865
482599
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lumican
Macaque
lumican
Mouse
Rat
Dog
lumican
Pathways (17)
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) (R-HSA-3656244)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
Reactome
Defective CHST6 causes MCDC1
Reactome
Defective ST3GAL3 causes MCT12 and EIEE15
Reactome
Disease
Reactome
Diseases associated with glycosaminoglycan metabolism
Name
Explore in Pharos
Explore in Source
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
Defective CHST6 causes MCDC1
Defective ST3GAL3 causes MCT12 and EIEE15
Disease
Diseases associated with glycosaminoglycan metabolism
Protein-Protein Interactions (180)
1 – 10 of 180
LRRC40
Tdark
Novelty: 2.43377466
p_int: 0.998988656
p_ni: 0.001011344
Score: 0.333
Data Source: BioPlex,STRINGDB
THUMPD1
Tdark
Novelty: 0.19420931
p_int: 0.915294509
p_ni: 0.081907702
p_wrong: 0.002797789
Score: 0.237
Data Source: BioPlex,STRINGDB
PTPN11
Tchem
Family: Enzyme
Novelty: 0.00073124
p_int: 0.843789415
p_ni: 0.155890132
p_wrong: 0.000320453
Score: 0.161
Data Source: BioPlex,STRINGDB
RHOA
Tbio
Family: Enzyme
Novelty: 0.00022204
p_int: 0.820544183
p_ni: 0.168361714
p_wrong: 0.011094102
Score: 0.305
Data Source: BioPlex,STRINGDB
CTH
Tchem
Family: Enzyme
Novelty: 0.0017155
p_int: 0.789244424
p_ni: 0.210755576
Score: 0.215
Data Source: BioPlex,STRINGDB
COL1A2
Tbio
Novelty: 0.00048334
Score: 0.995
Data Source: STRINGDB
ACAN
Tbio
Novelty: 0.00033695
Score: 0.978
Data Source: STRINGDB
COL3A1
Tbio
Novelty: 0.00197327
Score: 0.978
Data Source: STRINGDB
CHST6
Tbio
Family: Enzyme
Novelty: 0.01917947
Score: 0.974
Data Source: STRINGDB
CHST1
Tbio
Family: Enzyme
Novelty: 0.05238404
Score: 0.974
Data Source: STRINGDB
Publication Statistics
PubMed Score  464.27

PubMed score by year
PubTator Score  96.2

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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