Protein Summary
This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family that includes decorin, biglycan, fibromodulin, keratocan, epiphycan, and osteoglycin. In these bifunctional molecules, the protein moiety binds collagen fibrils and the highly charged hydrophilic glycosaminoglycans regulate interfibrillar spacings. Lumican is the major keratan sulfate proteoglycan of the cornea but is also distributed in interstitial collagenous matrices throughout the body. Lumican may regulate collagen fibril organization and circumferential growth, corneal transparency, and epithelial cell migration and tissue repair. [provided by RefSeq, Jul 2008]
- ENST00000266718
- ENSP00000266718
- ENSG00000139329
- LDC
- SLRR2D
- LDC
- SLRR2D
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
pathway | 0.95 | ||
disease perturbation | 0.93 | ||
biological process | 0.74 | ||
small molecule perturbation | 0.71 | ||
gene perturbation | 0.68 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 488.72 (req: < 5)
Gene RIFs: 67 (req: <= 3)
Antibodies: 328 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 488.72 (req: >= 5)
Gene RIFs: 67 (req: > 3)
Antibodies: 328 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 13
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
central corneal thickness | 2 | 1 | 0 | 3 | 15.6 | ||||
intraocular pressure measurement | 1 | 1 | 1 | 5 | |||||
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
central corneal thickness | 0 | 3 | 15.6 | ||||
intraocular pressure measurement | 1 | 5 | |||||
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | lumican | VGNC:5464 | 452119 | |||||
Macaque | lumican | 709830 | ||||||
Mouse | MGI:109347 | 17022 | ||||||
Rat | RGD:620984 | 81682 | ||||||
Dog | lumican | VGNC:42865 | 482599 | |||||
Protein Structure (0 Structures, 1 AlphaFold Model)
Pathways (17)
Reactome (15)
KEGG (1)
PathwayCommons (1)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 15
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) | ||||
Reactome | Defective CHST6 causes MCDC1 | ||||
Reactome | Defective ST3GAL3 causes MCT12 and EIEE15 | ||||
Reactome | Disease | ||||
Reactome | Diseases associated with glycosaminoglycan metabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) | ||||
Defective CHST6 causes MCDC1 | ||||
Defective ST3GAL3 causes MCT12 and EIEE15 | ||||
Disease | ||||
Diseases associated with glycosaminoglycan metabolism | ||||
Gene Ontology Terms (21)
Functions (3)
Components (8)
Processes (10)
Items per page:
10
1 – 3 of 3
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from High Throughput Direct Assay (HDA) | BHF-UCL | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Protein-Protein Interactions (180)
1 – 10 of 180
LRRC40
Novelty: 2.43377466
p_int: 0.998988656
p_ni: 0.001011344
Score: 0.333
Data Source: BioPlex,STRINGDB
THUMPD1
Novelty: 0.19420931
p_int: 0.915294509
p_ni: 0.081907702
p_wrong: 0.002797789
Score: 0.237
Data Source: BioPlex,STRINGDB
PTPN11
Family: Enzyme
Novelty: 0.00073124
p_int: 0.843789415
p_ni: 0.155890132
p_wrong: 0.000320453
Score: 0.161
Data Source: BioPlex,STRINGDB
RHOA
Family: Enzyme
Novelty: 0.00022204
p_int: 0.820544183
p_ni: 0.168361714
p_wrong: 0.011094102
Score: 0.305
Data Source: BioPlex,STRINGDB
CTH
Family: Enzyme
Novelty: 0.0017155
p_int: 0.789244424
p_ni: 0.210755576
Score: 0.215
Data Source: BioPlex,STRINGDB
COL1A2
Novelty: 0.00048334
Score: 0.995
Data Source: STRINGDB
ACAN
Novelty: 0.00033695
Score: 0.978
Data Source: STRINGDB
COL3A1
Novelty: 0.00197327
Score: 0.978
Data Source: STRINGDB
CHST6
Family: Enzyme
Novelty: 0.01917947
Score: 0.974
Data Source: STRINGDB
CHST1
Family: Enzyme
Novelty: 0.05238404
Score: 0.974
Data Source: STRINGDB
Publication Statistics
PubMed Score 488.72
PubMed score by year
PubTator Score 96.2
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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UniProt Keyword
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