Tbio LUM Lumican

Protein Summary

Description

This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family that includes decorin, biglycan, fibromodulin, keratocan, epiphycan, and osteoglycin. In these bifunctional molecules, the protein moiety binds collagen fibrils and the highly charged hydrophilic glycosaminoglycans regulate interfibrillar spacings. Lumican is the major keratan sulfate proteoglycan of the cornea but is also distributed in interstitial collagenous matrices throughout the body. Lumican may regulate collagen fibril organization and circumferential growth, corneal transparency, and epithelial cell migration and tissue repair. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P51884
• B2R6R5
• Q96QM7

Gene Name

• LUM

Ensembl ID

• ENST00000266718
• ENSP00000266718
• ENSG00000139329

Symbol

• LDC
• SLRR2D
• LDC
• SLRR2D

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
pathway	0.95
disease perturbation	0.93
biological process	0.74
small molecule perturbation	0.71
gene perturbation	0.68

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 572.68   (req: < 5)

Gene RIFs: 67   (req: <= 3)

Antibodies: 328   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 572.68   (req: >= 5)

Gene RIFs: 67   (req: > 3)

Antibodies: 328   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Pathways (17)

Reactome (15)

KEGG (1)

PathwayCommons (1)

Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) (R-HSA-3656244)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)	8 targets	R-HSA-3656244
Reactome	Defective CHST6 causes MCDC1	8 targets	R-HSA-3656225
Reactome	Defective ST3GAL3 causes MCT12 and EIEE15	8 targets	R-HSA-3656243
Reactome	Disease	1105 targets	R-HSA-1643685
Reactome	Diseases associated with glycosaminoglycan metabolism	41 targets	R-HSA-3560782

Name	Explore in Pharos	Explore in Source
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)	8 targets	R-HSA-3656244
Defective CHST6 causes MCDC1	8 targets	R-HSA-3656225
Defective ST3GAL3 causes MCT12 and EIEE15	8 targets	R-HSA-3656243
Disease	1105 targets	R-HSA-1643685
Diseases associated with glycosaminoglycan metabolism	41 targets	R-HSA-3560782

Gene Ontology Terms (21)

Functions (3)

Components (8)

Processes (10)

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Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
collagen binding	Inferred from Direct Assay (IDA)	UniProtKB
extracellular matrix structural constituent conferring compression resistance	Inferred from High Throughput Direct Assay (HDA)	BHF-UCL
extracellular matrix structural constituent	Non-traceable Author Statement (NAS)	UniProtKB

Protein-Protein Interactions (180)

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1 – 10 of 180

• See Interactions on String-DB

LRRC40

Tdark

Novelty: 7

p_int: 0.998988656

p_ni: 0.001011344

Score: 0.333

Data Source: BioPlex,STRINGDB

THUMPD1

Tbio

Novelty: 0.00148963

p_int: 0.915294509

p_ni: 0.081907702

p_wrong: 0.002797789

Score: 0.237

Data Source: BioPlex,STRINGDB

PTPN11

Tchem

Family: Enzyme

Novelty: 0.00086268

p_int: 0.843789415

p_ni: 0.155890132

p_wrong: 0.000320453

Score: 0.161

Data Source: BioPlex,STRINGDB

RHOA

Tbio

Family: Enzyme

Novelty: 0.0002729

p_int: 0.820544183

p_ni: 0.168361714

p_wrong: 0.011094102

Score: 0.305

Data Source: BioPlex,STRINGDB

CTH

Tchem

Family: Enzyme

Novelty: 0.00197728

p_int: 0.789244424

p_ni: 0.210755576

Score: 0.215

Data Source: BioPlex,STRINGDB

COL1A2

Tbio

Novelty: 0.00057274

Score: 0.995

Data Source: STRINGDB

ACAN

Tbio

Novelty: 0.00041383

Score: 0.978

Data Source: STRINGDB

COL3A1

Tbio

Novelty: 0.00231183

Score: 0.978

Data Source: STRINGDB

CHST6

Tbio

Family: Enzyme

Novelty: 0.02270215

Score: 0.974

Data Source: STRINGDB

CHST1

Tbio

Family: Enzyme

Novelty: 0.08353261

Score: 0.974

Data Source: STRINGDB

Publication Statistics

PubMed Score  572.68

PubMed score by year

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PubTator Score  96.2

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

Complete proteome
Direct protein sequencing
Disulfide bond
Extracellular matrix
Glycoprotein
Leucine-rich repeat
Phosphoprotein
Polymorphism
Proteoglycan
Pyrrolidone carboxylic acid

GWAS Trait Find Similar Targets

central corneal thickness
intraocular pressure measurement

MGI Phenotype Find Similar Targets

cardiovascular system phenotype
cellular phenotype
growth/size/body region phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype
integument phenotype
limbs/digits/tail phenotype
mortality/aging
muscle phenotype