Tchem CASP5 Caspase-5

Protein Summary

Description

Mediator of programmed cell death (apoptosis). During non-canonical inflammasome activation, cuts CGAS and may play a role in the regulation of antiviral innate immune activation (PubMed:28314590). This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Overexpression of the active form of this enzyme induces apoptosis in fibroblasts. Max, a central component of the Myc/Max/Mad transcription regulation network important for cell growth, differentiation, and apoptosis, is cleaved by this protein; this process requires Fas-mediated dephosphorylation of Max. The expression of this gene is regulated by interferon-gamma and lipopolysaccharide. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Aug 2010]

Uniprot Accession IDs

• P51878
• B4DKP5
• Q0QVY7
• Q0QVY8
• Q0QVZ0
• Q0QVZ1
• Q0QVZ2
• Q14DD6
• Q1HBJ3
• Q6DJV7
• CASP-5

Gene Name

• CASP5

Ensembl ID

• ENST00000260315
• ENSP00000260315
• ENSG00000137757
• ENST00000393141
• ENSP00000376849
• ENST00000418434
• ENSP00000398130
• ENST00000444749
• ENSP00000388365
• ENST00000456200
• ENSP00000408455
• ENST00000526056
• ENSP00000436877
• ENST00000531367
• ENSP00000434471

Symbol

• ICH3
• ICH-3
• ICEREL-III
• ICE(rel)III

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.99
virus perturbation	0.88
cell type or tissue	0.85
biological process	0.6
cell line	0.56

Protein Classes

PANTHER Classes

Protein / Hydrolase / Protease / Cysteine Protease / Caspase-5

Protein / Enzyme Modulator / Protease Inhibitor / Caspase-5

DTO Classes

Protein / Enzyme / Protease / Cysteine Protease / Caspase-5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 144.51   (req: < 5)

Gene RIFs: 35   (req: <= 3)

Antibodies: 515   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 144.51   (req: >= 5)

Gene RIFs: 35   (req: > 3)

Antibodies: 515   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 20

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0