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Tchem
CASP5
Caspase-5

Protein Summary
Description
Mediator of programmed cell death (apoptosis). During non-canonical inflammasome activation, cuts CGAS and may play a role in the regulation of antiviral innate immune activation (PubMed:28314590). This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Overexpression of the active form of this enzyme induces apoptosis in fibroblasts. Max, a central component of the Myc/Max/Mad transcription regulation network important for cell growth, differentiation, and apoptosis, is cleaved by this protein; this process requires Fas-mediated dephosphorylation of Max. The expression of this gene is regulated by interferon-gamma and lipopolysaccharide. Alternatively spliced transcript varian ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000260315
  • ENSP00000260315
  • ENSG00000137757
  • ENST00000393141
  • ENSP00000376849
  • ENST00000418434
  • ENSP00000398130
  • ENST00000444749
  • ENSP00000388365
  • ENST00000456200
  • ENSP00000408455
  • ENST00000526056
  • ENSP00000436877
  • ENST00000531367
  • ENSP00000434471

Symbol
  • ICH3
  • ICH-3
  • ICEREL-III
  • ICE(rel)III
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
virus perturbation
0.88
cell type or tissue
0.85
biological process
0.6
cell line
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 121.65   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 515   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 121.65   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 515   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 20
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (71)
CASP4
Tchem
Family:  Enzyme
Novelty:  0.00461865
p_int:  0.999999847
p_ni:  5e-9
p_wrong:  1.48e-7
Score:  0.893
Data Source:  BioPlex,STRINGDB
ARHGAP44
Tbio
Family:  Enzyme
Novelty:  0.11113234
p_int:  0.992134868
p_ni:  0.000478228
p_wrong:  0.007386904
Score:  0.345
Data Source:  BioPlex,STRINGDB
LACRT
Tbio
Novelty:  0.03333799
p_int:  0.916240649
p_ni:  0.076839055
p_wrong:  0.006920296
Score:  0.189
Data Source:  BioPlex,STRINGDB
NLRP1
Tbio
Novelty:  0.00441627
Score:  0.987
Data Source:  STRINGDB
PYCARD
Tbio
Novelty:  0.00719985
Score:  0.979
Data Source:  STRINGDB
NLRP3
Tchem
Novelty:  0.00043957
Score:  0.976
Data Source:  STRINGDB
CARD8
Tbio
Family:  Enzyme
Novelty:  0.0146799
Score:  0.97
Data Source:  STRINGDB
AIM2
Tbio
Novelty:  0.00360474
Score:  0.965
Data Source:  STRINGDB
GSDMD
Tchem
Novelty:  0.00500354
Score:  0.942
Data Source:  STRINGDB
CASP1
Tchem
Family:  Enzyme
Novelty:  0.00034643
Score:  0.936
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
caspase 5
VGNC:3194
735478
Macaque
caspase 5
704964
Mouse
MGI:107700
12363
Rat
RGD:621757
114555
Chicken
caspase 1
CGNC:49465
395764
Species
Name
OMA
EggNOG
Inparanoid
Chimp
caspase 5
Macaque
caspase 5
Mouse
Rat
Chicken
caspase 1
Publication Statistics
PubMed Score 121.65
PubMed score by year
PubTator Score 125.56
PubTator score by year
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Related Publications
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PMID
Year
Title