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Tbio
HDGF
Hepatoma-derived growth factor

Protein Summary
Description
Heparin-binding protein, with mitogenic activity for fibroblasts. Acts as a transcriptional repressor. This gene encodes a member of the hepatoma-derived growth factor family. The encoded protein has mitogenic and DNA-binding activity and may play a role in cellular proliferation and differentiation. High levels of expression of this gene enhance the growth of many tumors. This gene was thought initially to be located on chromosome X; however, that location has been determined to correspond to a related pseudogene. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357325
  • ENSP00000349878
  • ENSG00000143321
  • ENST00000368206
  • ENSP00000357189
  • ENST00000368209
  • ENSP00000357192
  • ENST00000537739
  • ENSP00000443120

Symbol
  • HMG1L2
  • HMG1L2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
co-expressed gene
0.94
molecular function
0.94
transcription factor binding site profile
0.93
PubMedID
0.87


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 324.55   (req: < 5)
Gene RIFs: 63   (req: <= 3)
Antibodies: 310   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 324.55   (req: >= 5)
Gene RIFs: 63   (req: > 3)
Antibodies: 310   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
2
2
2
73.8
platelet count
2
2
2
73.4
autoimmune thyroid disease
1
1
0
1.1
50.6
red blood cell distribution width
1
1
1
40.7
high density lipoprotein cholesterol measurement
2
1
2
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
2
73.8
platelet count
2
73.4
autoimmune thyroid disease
0
1.1
50.6
red blood cell distribution width
1
40.7
high density lipoprotein cholesterol measurement
2
21.5
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
heparin binding growth factor
VGNC:14800
457404
Mouse
MGI:1194494
15191
Rat
RGD:70961
114499
Dog
heparin binding growth factor
VGNC:41627
100856751
Horse
heparin binding growth factor
VGNC:18719
100064506
Species
Name
OMA
EggNOG
Inparanoid
Chimp
heparin binding growth factor
Mouse
Rat
Dog
heparin binding growth factor
Horse
heparin binding growth factor
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P51858-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
IRE1alpha activates chaperones (R-HSA-381070)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
IRE1alpha activates chaperones
Reactome
Metabolism of proteins
Reactome
Unfolded Protein Response (UPR)
Reactome
XBP1(S) activates chaperone genes
Name
Explore in Pharos
Explore in Source
IRE1alpha activates chaperones
Metabolism of proteins
Unfolded Protein Response (UPR)
XBP1(S) activates chaperone genes
Gene Ontology Terms (17)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (37)
1 – 10 of 37
HDGFL2
Tbio
Family:  Epigenetic
Novelty:  0.11846257
p_int:  0.999858734
p_ni:  0.000141266
Score:  0.414
Data Source:  BioPlex,STRINGDB
EGFL6
Tbio
Novelty:  0.04347552
p_int:  0.971171782
p_ni:  0.028828218
Score:  0.319
Data Source:  BioPlex,STRINGDB
CPNE2
Tdark
Novelty:  0.24188419
p_int:  0.867366497
p_ni:  0.132633503
Score:  0.187
Data Source:  BioPlex,STRINGDB
MDK
Tchem
Novelty:  0.00145301
Score:  0.869
Data Source:  STRINGDB
POGZ
Tbio
Novelty:  0.03603188
Score:  0.806
Data Source:  STRINGDB
SMYD1
Tbio
Family:  Epigenetic
Novelty:  0.03781475
Score:  0.738
Data Source:  STRINGDB
PTN
Tchem
Novelty:  0.00129524
Score:  0.715
Data Source:  STRINGDB
TRIP12
Tbio
Family:  Enzyme
Novelty:  0.03433452
Score:  0.67
Data Source:  STRINGDB
NUDT6
Tbio
Novelty:  0.03648851
Score:  0.641
Data Source:  STRINGDB
FGF2
Tchem
Novelty:  0.00007856
Score:  0.589
Data Source:  STRINGDB
Publication Statistics
PubMed Score  324.55

PubMed score by year
PubTator Score  112.47

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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