HDGF
Hepatoma-derived growth factor
Protein Summary
Heparin-binding protein, with mitogenic activity for fibroblasts. Acts as a transcriptional repressor. This gene encodes a member of the hepatoma-derived growth factor family. The encoded protein has mitogenic and DNA-binding activity and may play a role in cellular proliferation and differentiation. High levels of expression of this gene enhance the growth of many tumors. This gene was thought initially to be located on chromosome X; however, that location has been determined to correspond to a related pseudogene. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jan 2016]
- ENST00000357325
- ENSP00000349878
- ENSG00000143321
- ENST00000368206
- ENSP00000357189
- ENST00000368209
- ENSP00000357192
- ENST00000537739
- ENSP00000443120
- HMG1L2
- HMG1L2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 0.99 | ||
co-expressed gene | 0.94 | ||
molecular function | 0.94 | ||
transcription factor binding site profile | 0.93 | ||
PubMedID | 0.87 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 334.68 (req: < 5)
Gene RIFs: 80 (req: <= 3)
Antibodies: 310 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 334.68 (req: >= 5)
Gene RIFs: 80 (req: > 3)
Antibodies: 310 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0