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Tbio
HDGF
Hepatoma-derived growth factor

Protein Summary
Description
Heparin-binding protein, with mitogenic activity for fibroblasts. Acts as a transcriptional repressor. This gene encodes a member of the hepatoma-derived growth factor family. The encoded protein has mitogenic and DNA-binding activity and may play a role in cellular proliferation and differentiation. High levels of expression of this gene enhance the growth of many tumors. This gene was thought initially to be located on chromosome X; however, that location has been determined to correspond to a related pseudogene. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357325
  • ENSP00000349878
  • ENSG00000143321
  • ENST00000368206
  • ENSP00000357189
  • ENST00000368209
  • ENSP00000357192
  • ENST00000537739
  • ENSP00000443120

Symbol
  • HMG1L2
  • HMG1L2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
co-expressed gene
0.94
molecular function
0.94
transcription factor binding site profile
0.93
PubMedID
0.87


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 334.68   (req: < 5)
Gene RIFs: 63   (req: <= 3)
Antibodies: 310   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 334.68   (req: >= 5)
Gene RIFs: 63   (req: > 3)
Antibodies: 310   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0