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Tbio
AKR1D1
3-oxo-5-beta-steroid 4-dehydrogenase

Protein Summary
Description
Efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites. The bile acid intermediates 7-alpha,12-alpha-dihydroxy-4-cholesten-3-one and 7-alpha-hydroxy-4-cholesten-3-one can also act as substrates. The enzyme encoded by this gene is responsible for the catalysis of the 5-beta-reduction of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure. Deficiency of this enzyme may contribute to hepatic dysfunction. Three transcript variants encoding different isoforms have been found for this gene. Other variants may be present, but their full-length natures have not been determined yet. [provided by RefSeq, Jul 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000242375
  • ENSP00000242375
  • ENSG00000122787
  • ENST00000411726
  • ENSP00000402374
  • ENST00000432161
  • ENSP00000389197

Symbol
  • SRD5B1
  • CBAS2
  • SRD5B1
  • 3o5bred
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.88
cell type or tissue
0.62
protein domain
0.58
co-expressed gene
0.57
disease
0.54


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.86   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 212   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.86   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 212   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (77)
APLNR
Tchem
Family:  GPCR
Novelty:  0.00224203
p_int:  0.999984238
p_ni:  0.000015762
Data Source:  BioPlex
GEMIN5
Tbio
Novelty:  0.03683801
p_int:  0.999908165
p_ni:  0.000091835
Score:  0.228
Data Source:  BioPlex,STRINGDB
AKR1C1
Tchem
Family:  Enzyme
Novelty:  0.0043847
p_int:  0.999899971
p_ni:  0.000067347
p_wrong:  0.000032682
Score:  0.986
Data Source:  BioPlex,STRINGDB
AKR1C3
Tchem
Family:  Enzyme
Novelty:  0.00257785
p_int:  0.999895163
p_ni:  0.000067742
p_wrong:  0.000037094
Score:  0.985
Data Source:  BioPlex,STRINGDB
DIRAS1
Tbio
Family:  Enzyme
Novelty:  0.13332903
p_int:  0.999544143
p_ni:  0.000455855
p_wrong:  2e-9
Score:  0.507
Data Source:  BioPlex,STRINGDB
SIRT1
Tchem
Family:  Epigenetic
Novelty:  0.00022265
p_int:  0.986024887
p_ni:  0.013975112
Score:  0.201
Data Source:  BioPlex,STRINGDB
AKR1B10
Tchem
Family:  Enzyme
Novelty:  0.00533958
p_int:  0.9731707
p_ni:  0.026802638
p_wrong:  0.000026662
Score:  0.282
Data Source:  BioPlex,STRINGDB
HSD3B7
Tbio
Family:  Enzyme
Novelty:  0.04791842
Score:  0.977
Data Source:  STRINGDB
SRD5A1
Tclin
Family:  Enzyme
Novelty:  0.00987219
Score:  0.964
Data Source:  STRINGDB
SRD5A2
Tclin
Family:  Enzyme
Novelty:  0.00281044
Score:  0.959
Data Source:  STRINGDB
Nearest Tclin Targets (11)
Explore Nearest Tclin Targets
1 – 5 of 6
CYP19A1
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
SRD5A2
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  1
CYP17A1
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
HSD3B2
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
SRD5A1
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  1
Pathways (18)
Bile acid and bile salt metabolism (R-HSA-194068)

Click on a row in the table to change the structure displayed.

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1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Bile acid and bile salt metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Metabolism of steroids
Reactome
Synthesis of bile acids and bile salts
Name
Explore in Pharos
Explore in Source
Bile acid and bile salt metabolism
Metabolism
Metabolism of lipids
Metabolism of steroids
Synthesis of bile acids and bile salts
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (17)
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Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Disease Associations ()
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
5
3
5
96.1
blood metabolite measurement
2
2
2
84.3
BMI-adjusted waist circumference
2
3
3
70.9
IGF-1 measurement
1
1
1
56.6
alkaline phosphatase measurement
1
1
1
54.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
5
96.1
blood metabolite measurement
2
84.3
BMI-adjusted waist circumference
3
70.9
IGF-1 measurement
1
56.6
alkaline phosphatase measurement
1
54.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
aldo-keto reductase family 1 member D1
VGNC:50367
472607
Macaque
aldo-keto reductase family 1 member D1
709863
Mouse
MGI:2384785
208665
Rat
RGD:620752
192242
Horse
aldo-keto reductase family 1 member D1
VGNC:15215
100066919
Species
Name
OMA
EggNOG
Inparanoid
Chimp
aldo-keto reductase family 1 member D1
Macaque
aldo-keto reductase family 1 member D1
Mouse
Rat
Horse
aldo-keto reductase family 1 member D1
Publication Statistics
PubMed Score 82.86
PubMed score by year
PubTator Score 44.72
PubTator score by year
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Related Publications
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PMID
Year
Title