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Tbio
TKTL1
Transketolase-like protein 1

Protein Summary
Description
Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. The protein encoded by this gene is a transketolase that acts as a homodimer and catalyzes the conversion of sedoheptulose 7-phosphate and D-glyceraldehyde 3-phosphate to D-ribose 5-phosphate and D-xylulose 5-phosphate. This reaction links the pentose phosphate pathway with the glycolytic pathway. Variations in this gene may be the cause of Wernicke-Korsakoff syndrome. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369912
  • ENSP00000358928
  • ENSG00000007350
  • ENST00000369915
  • ENSP00000358931

Symbol
  • TKR
  • TKT2
  • TKR
  • TKT2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
tissue
0.55
tissue sample
0.54
biological term
0.53
gene perturbation
0.52


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 87.83   (req: < 5)
Gene RIFs: 43   (req: <= 3)
Antibodies: 60   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 87.83   (req: >= 5)
Gene RIFs: 43   (req: > 3)
Antibodies: 60   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
3
2
3
82.6
reticulocyte count
2
2
2
60.5
reticulocyte measurement
2
2
2
59.3
bilirubin measurement
1
1
1
55.5
1
1
0
1.4
26.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
3
82.6
reticulocyte count
2
60.5
reticulocyte measurement
2
59.3
bilirubin measurement
1
55.5
0
1.4
26.7
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transketolase like 1
VGNC:11621
465937
Macaque
transketolase like 1
699278
Dog
transketolase like 1
VGNC:47392
481083
Horse
transketolase like 1
VGNC:24124
100059329
Cow
transketolase like 1
VGNC:35885
507517
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transketolase like 1
Macaque
transketolase like 1
Dog
transketolase like 1
Horse
transketolase like 1
Cow
transketolase like 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P51854-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (8)
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Carbon metabolism
KEGG
Metabolic pathways
KEGG
Biosynthesis of amino acids
KEGG
Pentose phosphate pathway
Name
Explore in Pharos
Explore in Source
Carbon metabolism
Metabolic pathways
Biosynthesis of amino acids
Pentose phosphate pathway
Gene Ontology Terms (6)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (124)
1 – 10 of 124
HSP90AB4P
Tdark
p_int: 0.987361053
p_ni: 0.012638947
Data Source: BioPlex
DNAJB5
Tbio
Novelty: 0.20703358
p_int: 0.957396177
p_ni: 0.042601841
p_wrong: 0.000001982
Score: 0.254
Data Source: BioPlex,STRINGDB
TUBB8
Tclin
Novelty: 0.06403117
p_int: 0.862531449
p_ni: 0.137468551
Data Source: BioPlex
RICTOR
Tbio
Novelty: 0.00250734
p_int: 0.781225446
p_ni: 0.218511886
p_wrong: 0.000262668
Score: 0.157
Data Source: BioPlex,STRINGDB
VSIG8
Tdark
Novelty: 1.16023405
p_int: 0.778680644
p_ni: 0.221319356
Score: 0.183
Data Source: BioPlex,STRINGDB
TUBA1A
Tchem
Novelty: 0.01030145
p_int: 0.757083747
p_ni: 0.242916253
Score: 0.258
Data Source: BioPlex,STRINGDB
TALDO1
Tbio
Family: Enzyme
Novelty: 0.00208619
Score: 0.989
Data Source: STRINGDB
RPE
Tbio
Family: Enzyme
Novelty: 0.01035554
Score: 0.974
Data Source: STRINGDB
RPIA
Tbio
Family: Enzyme
Novelty: 0.00968705
Score: 0.973
Data Source: STRINGDB
RPEL1
Tbio
Family: Enzyme
Novelty: 0.40871656
Score: 0.97
Data Source: STRINGDB
Publication Statistics
PubMed Score  87.83

PubMed score by year
PubTator Score  75.34

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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