NR0B1
Nuclear receptor subfamily 0 group B member 1
Protein Summary
Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency (By similarity). This gene encodes a protein that contains a DNA-binding domain. The encoded protein acts as a dominant-negative regulator of transcription which is mediated by the retinoic acid receptor. This protein also functions as an anti-testis gene by acting antagonistically to Sry. Mutations in this gene result in both X-linked congenital adrenal hypoplasia and hypogonadotropic hypogonadism. [provided by RefSeq, Jul 2008]
- ENST00000378970
- ENSP00000368253
- ENSG00000169297
- AHC
- DAX1
- AHC
- AHX
- DSS
- GTD
- HHG
- AHCH
- DAX1
- DAX-1
- NROB1
- SRXY2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.97 | ||
biological process | 0.84 | ||
biological term | 0.78 | ||
gene perturbation | 0.77 | ||
PubMedID | 0.74 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 702.64 (req: < 5)
Gene RIFs: 103 (req: <= 3)
Antibodies: 599 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 702.64 (req: >= 5)
Gene RIFs: 103 (req: > 3)
Antibodies: 599 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 31
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0