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Tbio
ADCY7
Adenylate cyclase type 7

Protein Summary
Description
Catalyzes the formation of cAMP in response to activation of G protein-coupled receptors (Probable). Functions in signaling cascades activated namely by thrombin and sphingosine 1-phosphate and mediates regulation of cAMP synthesis through synergistic action of the stimulatory G alpha protein with GNA13 (PubMed:23229509, PubMed:18541530). Also, during inflammation, mediates zymosan-induced increase intracellular cAMP, leading to protein kinase A pathway activation in order to modulate innate immune responses through heterotrimeric G proteins G(12/13) (By similarity). Functions in signaling cascades activated namely by dopamine and C5 alpha chain and mediates regulation of cAMP synthesis through synergistic action of the stimulatory G protein with G beta:gamma complex (PubMed:23842570, PubMed:23229509). Functions, through cAMP response regulation, to keep inflammation under control during bacterial infection by sensing the presence of serum factors, such as the bioactive lysophospholipi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000254235
  • ENSP00000254235
  • ENSG00000121281
  • ENST00000394697
  • ENSP00000378187

Symbol
  • KIAA0037
  • AC7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
molecular function
0.9
transcription factor perturbation
0.88
pathway
0.84
PubMedID
0.81


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 99.52   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 145   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 99.52   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 145   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
2.2
89.3
eosinophil count
2
1
2
63.3
autoimmune thyroid disease
1
1
0
1.5
59.4
eosinophil percentage of leukocytes
1
1
1
37
Thyroid preparation use measurement
1
1
1
19.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
2.2
89.3
eosinophil count
2
63.3
autoimmune thyroid disease
0
1.5
59.4
eosinophil percentage of leukocytes
1
37
Thyroid preparation use measurement
1
19.5
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
adenylate cyclase 7
VGNC:5666
473278
Macaque
adenylate cyclase 7
694730
Mouse
MGI:102891
11513
Rat
RGD:619966
84420
Dog
adenylate cyclase 7
VGNC:37624
487289
Species
Name
OMA
EggNOG
Inparanoid
Chimp
adenylate cyclase 7
Macaque
adenylate cyclase 7
Mouse
Rat
Dog
adenylate cyclase 7
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P51828-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (117)
Activation of GABAB receptors (R-HSA-991365)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 33
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of GABAB receptors
Reactome
Adenylate cyclase activating pathway
Reactome
Adenylate cyclase inhibitory pathway
Reactome
Aquaporin-mediated transport
Reactome
Ca-dependent events
Name
Explore in Pharos
Explore in Source
Activation of GABAB receptors
Adenylate cyclase activating pathway
Adenylate cyclase inhibitory pathway
Aquaporin-mediated transport
Ca-dependent events
Gene Ontology Terms (17)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (461)
1 – 10 of 461
DRD1
Tclin
Family: GPCR
Novelty: 0.00165886
Score: 0.96
Data Source: STRINGDB
DRD5
Tchem
Family: GPCR
Novelty: 0.00803909
Score: 0.959
Data Source: STRINGDB
DRD2
Tclin
Family: GPCR
Novelty: 0.00033797
Score: 0.956
Data Source: STRINGDB
GNAL
Tbio
Novelty: 0.01757098
Score: 0.955
Data Source: STRINGDB
GNAS
Tbio
Novelty: 0.00284739
Score: 0.952
Data Source: STRINGDB
GNAS
Tbio
Novelty: 0.00284739
Score: 0.952
Data Source: STRINGDB
GNAS
Tbio
Novelty: 0.00284739
Score: 0.952
Data Source: STRINGDB
GNAS
Tbio
Novelty: 0.00284739
Score: 0.952
Data Source: STRINGDB
PRKAR1B
Tbio
Family: Enzyme
Novelty: 0.05355517
Score: 0.947
Data Source: STRINGDB
GCG
Tchem
Novelty: 0.00004879
Score: 0.945
Data Source: STRINGDB
Publication Statistics
PubMed Score  99.52

PubMed score by year
PubTator Score  26.23

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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