Tchem PRKX cAMP-dependent protein kinase catalytic subunit PRKX

Protein Summary

Description

Serine/threonine protein kinase regulated by and mediating cAMP signaling in cells. Acts through phosphorylation of downstream targets that may include CREB, SMAD6 and PKD1 and has multiple functions in cellular differentiation and epithelial morphogenesis. Regulates myeloid cell differentiation through SMAD6 phosphorylation. Involved in nephrogenesis by stimulating renal epithelial cell migration and tubulogenesis. Also involved in angiogenesis through stimulation of endothelial cell proliferation, migration and vascular-like structure formation. This gene encodes a serine threonine protein kinase that has similarity to the catalytic subunit of cyclic AMP dependent protein kinases. The encoded protein is developmentally regulated and may be involved in renal epithelial morphogenesis. This protein may also be involved in macrophage and granulocyte maturation. Abnormal recombination between this gene and a related pseudogene on chromosome Y is a frequent cause of sex reversal disorder in XX males and XY females. Pseudogenes of this gene are found on chromosomes X, 15 and Y. [provided by RefSeq, Feb 2010]

Uniprot Accession IDs

• P51817
• PrKX

Gene Name

• PRKX

Ensembl ID

• ENST00000262848
• ENSP00000262848
• ENSG00000183943

Symbol

• PKX1
• PKX1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.99
molecular function	0.94
protein domain	0.85
pathway	0.79
virus perturbation	0.79

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Agc Group / Pka Family / Camp-dependent Protein Kinase Catalytic Subunit Prkx

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.39   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 219   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.39   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 219   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 48

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0