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Tchem
PRKX
cAMP-dependent protein kinase catalytic subunit PRKX

Protein Summary
Description
Serine/threonine protein kinase regulated by and mediating cAMP signaling in cells. Acts through phosphorylation of downstream targets that may include CREB, SMAD6 and PKD1 and has multiple functions in cellular differentiation and epithelial morphogenesis. Regulates myeloid cell differentiation through SMAD6 phosphorylation. Involved in nephrogenesis by stimulating renal epithelial cell migration and tubulogenesis. Also involved in angiogenesis through stimulation of endothelial cell proliferation, migration and vascular-like structure formation. This gene encodes a serine threonine protein kinase that has similarity to the catalytic subunit of cyclic AMP dependent protein kinases. The encoded protein is developmentally regulated and may be involved in renal epithelial morphogenesis. This protein may also be involved in macrophage and granulocyte maturation. Abnormal recombination between this gene and a related pseudogene on chromosome Y is a frequent cause of sex reversal disorder i ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262848
  • ENSP00000262848
  • ENSG00000183943

Symbol
  • PKX1
  • PKX1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
molecular function
0.94
protein domain
0.85
pathway
0.79
virus perturbation
0.79


Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.33   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 219   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.33   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 219   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 48
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
2
2
84.6
thyroid stimulating hormone measurement
1
1
1
49.5
lymphocyte percentage of leukocytes
1
1
1
28
neutrophil percentage of leukocytes
1
1
1
12.9
leukocyte count
1
1
1
12.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
84.6
thyroid stimulating hormone measurement
1
49.5
lymphocyte percentage of leukocytes
1
28
neutrophil percentage of leukocytes
1
12.9
leukocyte count
1
12.3
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein kinase, X-linked
751063
Macaque
protein kinase, X-linked
100270699
Mouse
MGI:1309999
19108
Rat
RGD:1564076
501563
Dog
protein kinase, X-linked
610031
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein kinase, X-linked
Macaque
protein kinase, X-linked
Mouse
Rat
Dog
protein kinase, X-linked
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P51817-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (32)
Activation of NMDA receptors and postsynaptic events (R-HSA-442755)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of NMDA receptors and postsynaptic events
Reactome
CREB1 phosphorylation through the activation of Adenylate Cyclase
Reactome
Ca-dependent events
Reactome
CaM pathway
Reactome
Calmodulin induced events
Name
Explore in Pharos
Explore in Source
Activation of NMDA receptors and postsynaptic events
CREB1 phosphorylation through the activation of Adenylate Cyclase
Ca-dependent events
CaM pathway
Calmodulin induced events
Gene Ontology Terms (17)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (111)
1 – 10 of 111
PRKAR2B
Tchem
Family:  Enzyme
Novelty:  0.00456972
p_int:  0.999999999
p_wrong:  1e-9
Score:  0.859
Data Source:  BioPlex,STRINGDB
PRKAR1A
Tbio
Family:  Enzyme
Novelty:  0.00311432
Score:  0.917
Data Source:  STRINGDB
OSTC
Tbio
Family:  Enzyme
Novelty:  0.06699106
Score:  0.905
Data Source:  STRINGDB
PRKAR2A
Tchem
Family:  Enzyme
Novelty:  0.06183318
Score:  0.888
Data Source:  STRINGDB
PRKAR1B
Tbio
Family:  Enzyme
Novelty:  0.05355517
Score:  0.856
Data Source:  STRINGDB
PKIA
Tbio
Family:  Enzyme
Novelty:  0.02581954
Score:  0.853
Data Source:  STRINGDB
TBL1X
Tbio
Novelty:  0.00027212
Score:  0.786
Data Source:  STRINGDB
VCX3A
Tbio
Novelty:  0.07353654
Score:  0.761
Data Source:  STRINGDB
ZFX
Tbio
Family:  TF
Novelty:  0.00382489
Score:  0.753
Data Source:  STRINGDB
USP9X
Tbio
Family:  Enzyme
Novelty:  0.00820155
Score:  0.702
Data Source:  STRINGDB
Publication Statistics
PubMed Score  39.33

PubMed score by year
PubTator Score  21.95

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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