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Tbio
AFF2
AF4/FMR2 family member 2

Protein Summary
Description
RNA-binding protein. Might be involved in alternative splicing regulation through an interaction with G-quartet RNA structure. This gene encodes a putative transcriptional activator that is a member of the AF4\FMR2 gene family. This gene is associated with the folate-sensitive fragile X E locus on chromosome X. A repeat polymorphism in the fragile X E locus results in silencing of this gene causing Fragile X E syndrome. Fragile X E syndrome is a form of nonsyndromic X-linked cognitive disability. In addition, this gene contains 6-25 GCC repeats that are expanded to >200 repeats in the disease state. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jul 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000286437
  • ENSP00000286437
  • ENSG00000155966
  • ENST00000342251
  • ENSP00000345459
  • ENST00000370457
  • ENSP00000359486
  • ENST00000370458
  • ENSP00000359487
  • ENST00000370460
  • ENSP00000359489

Symbol
  • FMR2
  • OX19
  • FMR2
  • MRX2
  • OX19
  • FMR2P
  • FRAXE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.97
trait
0.93
microRNA
0.92
tissue
0.62
tissue sample
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 330.84   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 145   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 330.84   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 145   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (53)
FMR1
Tbio
Family:  Epigenetic
Novelty:  0.00032203
Score:  0.846
Data Source:  STRINGDB
TMEM185A
Tdark
Novelty:  0.0262898
Score:  0.804
Data Source:  STRINGDB
TEX13A
Tdark
Novelty:  1.13928013
Score:  0.721
Data Source:  STRINGDB
FRA10AC1
Tdark
Novelty:  0.25570773
Score:  0.72
Data Source:  STRINGDB
CUL4B
Tbio
Novelty:  0.0133075
Score:  0.667
Data Source:  STRINGDB
ARL13A
Tdark
Family:  Enzyme
Novelty:  0.19381742
Score:  0.666
Data Source:  STRINGDB
AKAP4
Tbio
Family:  Enzyme
Novelty:  0.00760557
Score:  0.652
Data Source:  STRINGDB
CYLC1
Tdark
Novelty:  0.04505517
Score:  0.65
Data Source:  STRINGDB
ARHGEF6
Tbio
Novelty:  0.02162737
Score:  0.598
Data Source:  STRINGDB
OPHN1
Tbio
Novelty:  0.0147527
Score:  0.596
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
basophil percentage of leukocytes
1
3
3
90.6
monocyte percentage of leukocytes
1
3
3
89
basophil count
1
2
2
83.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
basophil percentage of leukocytes
3
90.6
monocyte percentage of leukocytes
3
89
basophil count
2
83.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
AF4/FMR2 family member 2
VGNC:6427
450122
Macaque
AF4/FMR2 family member 2
700758
Mouse
MGI:1202294
14266
Rat
RGD:1565592
293922
Dog
AF4/FMR2 family member 2
VGNC:49896
492193
Species
Name
OMA
EggNOG
Inparanoid
Chimp
AF4/FMR2 family member 2
Macaque
AF4/FMR2 family member 2
Mouse
Rat
Dog
AF4/FMR2 family member 2
Publication Statistics
PubMed Score 330.84
PubMed score by year
PubTator Score 57.52
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title