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Tchem
RPS6KA3
Ribosomal protein S6 kinase alpha-3

Protein Summary
Description
Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1 and histone H3 at 'Ser-10', which results in the subsequent transcriptional activation of several immediate-early genes. In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP. Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity. Phosphorylates RPS6 in response to serum or EGF via an mTOR-indepen ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379565
  • ENSP00000368884
  • ENSG00000177189
  • ENST00000645845
  • ENSP00000494131

Symbol
  • ISPK1
  • MAPKAPK1B
  • RSK2
  • CLS
  • RSK
  • HU-3
  • RSK2
  • MRX19
  • ISPK-1
  • p90-RSK2
  • pp90RSK2
  • MAPKAPK1B
  • S6K-alpha3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
molecular function
1
interacting protein
0.99
kinase
0.99
protein domain
0.97


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 517.85   (req: < 5)
Gene RIFs: 76   (req: <= 3)
Antibodies: 544   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 517.85   (req: >= 5)
Gene RIFs: 76   (req: > 3)
Antibodies: 544   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 141
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0