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Tbio
GPR143
G-protein coupled receptor 143

Protein Summary
Description
Receptor for tyrosine, L-DOPA and dopamine. After binding to L-DOPA, stimulates Ca(2+) influx into the cytoplasm, increases secretion of the neurotrophic factor SERPINF1 and relocalizes beta arrestin at the plasma membrane; this ligand-dependent signaling occurs through a G(q)-mediated pathway in melanocytic cells. Its activity is mediated by G proteins which activate the phosphoinositide signaling pathway. Plays also a role as an intracellular G protein-coupled receptor involved in melanosome biogenesis, organization and transport. This gene encodes a protein that binds to heterotrimeric G proteins and is targeted to melanosomes in pigment cells. This protein is thought to be involved in intracellular signal transduction mechanisms. Mutations in this gene cause ocular albinism type 1, also referred to as Nettleship-Falls type ocular albinism, a severe visual disorder. A related pseudogene has been identified on chromosome Y. [provided by RefSeq, Dec 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000467482
  • ENSP00000417161
  • ENSG00000101850

Symbol
  • OA1
  • OA1
  • NYS6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.9
cellular component
0.88
virus perturbation
0.72
tissue sample
0.65
cell type or tissue
0.55


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.62   (req: < 5)
Gene RIFs: 45   (req: <= 3)
Antibodies: 146   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.62   (req: >= 5)
Gene RIFs: 45   (req: > 3)
Antibodies: 146   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
IDG Resources
Genetic Construct
GPR143-Tango
image for GPR143-Tango
Details:
  • Vector:  addgene66320
  • Vector backbone:  pcDNA3.1(+)
  • Promoter:  CMV
  • Tag:  FLAG
Data:
  • GPR143-Tango
Order Genetic Construct from:
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.1
63.6
2
1
0
1.1
54.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
63.6
0
1.1
54.4
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
G protein-coupled receptor 143
709148
Mouse
MGI:107193
18241
Rat
RGD:1565799
302619
Horse
G protein-coupled receptor 143
VGNC:18515
100147328
Cow
G protein-coupled receptor 143
613505
Species
Name
OMA
EggNOG
Inparanoid
Macaque
G protein-coupled receptor 143
Mouse
Rat
Horse
G protein-coupled receptor 143
Cow
G protein-coupled receptor 143
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P51810-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (8)
Amine ligand-binding receptors (R-HSA-375280)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amine ligand-binding receptors
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Amine ligand-binding receptors
Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Protein-Protein Interactions (209)
1 – 10 of 209
EDNRB
Tclin
Family:  GPCR
Novelty:  0.00053875
Score:  0.933
Data Source:  STRINGDB
CYSLTR1
Tclin
Family:  GPCR
Novelty:  0.00337777
Score:  0.918
Data Source:  STRINGDB
GNG4
Tbio
Novelty:  0.14371438
Score:  0.915
Data Source:  STRINGDB
GNRHR
Tclin
Family:  GPCR
Novelty:  0.00203671
Score:  0.914
Data Source:  STRINGDB
AGTR1
Tclin
Family:  GPCR
Novelty:  0.00033439
Score:  0.911
Data Source:  STRINGDB
HTR2B
Tclin
Family:  GPCR
Novelty:  0.00237051
Score:  0.911
Data Source:  STRINGDB
F2RL1
Tchem
Family:  GPCR
Novelty:  0.00445327
Score:  0.911
Data Source:  STRINGDB
MCHR2
Tchem
Family:  GPCR
Novelty:  0.01191922
Score:  0.91
Data Source:  STRINGDB
PTAFR
Tchem
Family:  GPCR
Novelty:  0.00755426
Score:  0.909
Data Source:  STRINGDB
GRPR
Tchem
Family:  GPCR
Novelty:  0.00282511
Score:  0.908
Data Source:  STRINGDB
Publication Statistics
PubMed Score  76.62

PubMed score by year
PubTator Score  47.4

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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