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Tbio
VAMP7
Vesicle-associated membrane protein 7

Protein Summary
Description
Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocytosis of late endocytic vesicles during phagosome formation. This gene encodes a transmembrane protein that is a member of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) family. The encoded protein localizes to late endosomes and lysosomes and is involved in the fusion of transport vesicles to their target membranes. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jun 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262640
  • ENSP00000262640
  • ENSG00000124333
  • ENST00000286448
  • ENSP00000286448
  • ENST00000460621
  • ENSP00000427822

Symbol
  • SYBL1
  • SYBL1
  • TIVAMP
  • VAMP-7
  • TI-VAMP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.95
histone modification site profile
0.88
cellular component
0.86
transcription factor perturbation
0.84
interacting protein
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 126.64   (req: < 5)
Gene RIFs: 35   (req: <= 3)
Antibodies: 202   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 126.64   (req: >= 5)
Gene RIFs: 35   (req: > 3)
Antibodies: 202   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (300)
1 – 10 of 300
STX12
Tbio
Novelty:  0.03836262
p_int:  0.989579802
p_ni:  0.010420198
Score:  0.987
Data Source:  BioPlex,STRINGDB
SNAP29
Tbio
Novelty:  0.02009206
p_int:  0.9534844
p_ni:  0.0465156
Score:  0.996
Data Source:  BioPlex,STRINGDB
SIRT2
Tchem
Family:  Epigenetic
Novelty:  0.00093962
p_int:  0.890779918
p_ni:  0.109220082
Score:  0.189
Data Source:  BioPlex,STRINGDB
STX7
Tbio
Novelty:  0.03109969
p_int:  0.841014952
p_ni:  0.158985048
Score:  0.985
Data Source:  BioPlex,STRINGDB
GINM1
Tdark
Novelty:  1.0701107
p_int:  0.837152411
p_ni:  0.162847589
Data Source:  BioPlex
SNAP23
Tbio
Novelty:  0.0065371
Score:  0.995
Data Source:  Reactome,STRINGDB
STX6
Tbio
Novelty:  0.01494028
Score:  0.99
Data Source:  STRINGDB
STX4
Tbio
Novelty:  0.00831588
Score:  0.988
Data Source:  Reactome,STRINGDB
SNAP25
Tclin
Novelty:  0.00148905
Score:  0.987
Data Source:  STRINGDB
VAMP8
Tbio
Novelty:  0.01083228
Score:  0.984
Data Source:  STRINGDB
Pathways (13)
Cargo recognition for clathrin-mediated endocytosis (R-HSA-8856825)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Clathrin-mediated endocytosis
Reactome
Cytokine Signaling in Immune system
Reactome
Golgi Associated Vesicle Biogenesis
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Cytokine Signaling in Immune system
Golgi Associated Vesicle Biogenesis
Immune System
Gene Ontology Terms (48)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil percentage of leukocytes
1
2
2
64
eosinophil count
1
2
2
58.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil percentage of leukocytes
2
64
eosinophil count
2
58.3
Find similar targets by:
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
vesicle associated membrane protein 7
704160
Mouse
MGI:1096399
20955
Rat
RGD:621558
85491
Dog
vesicle associated membrane protein 7
VGNC:48226
612663
Horse
vesicle associated membrane protein 7
VGNC:24878
100062131
Species
Name
OMA
EggNOG
Inparanoid
Macaque
vesicle associated membrane protein 7
Mouse
Rat
Dog
vesicle associated membrane protein 7
Horse
vesicle associated membrane protein 7
Publication Statistics
PubMed Score 126.64
PubMed score by year
PubTator Score 63.12
PubTator score by year