Tbio VAMP7 Vesicle-associated membrane protein 7

Protein Summary

Description

Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocytosis of late endocytic vesicles during phagosome formation. This gene encodes a transmembrane protein that is a member of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) family. The encoded protein localizes to late endosomes and lysosomes and is involved in the fusion of transport vesicles to their target membranes. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jun 2010]

Uniprot Accession IDs

• P51809
• Q53GY7
• Q7Z409
• Q9H4A7
• VAMP-7

Gene Name

• VAMP7

Ensembl ID

• ENST00000262640
• ENSP00000262640
• ENSG00000124333
• ENST00000286448
• ENSP00000286448
• ENST00000460621
• ENSP00000427822

Symbol

• SYBL1
• SYBL1
• TIVAMP
• VAMP-7
• TI-VAMP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.95
histone modification site profile	0.88
cellular component	0.86
transcription factor perturbation	0.84
interacting protein	0.74

Protein Classes

PANTHER Classes

Protein / Membrane Traffic Protein / Snare Protein / Vesicle-associated Membrane Protein 7

DTO Classes

Protein / Transporter / Snare Protein / Vesicle-associated Membrane Protein 7

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 141.97   (req: < 5)

Gene RIFs: 46   (req: <= 3)

Antibodies: 202   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 141.97   (req: >= 5)

Gene RIFs: 46   (req: > 3)

Antibodies: 202   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0