VAMP7
Vesicle-associated membrane protein 7
Protein Summary
Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocytosis of late endocytic vesicles during phagosome formation. This gene encodes a transmembrane protein that is a member of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) family. The encoded protein localizes to late endosomes and lysosomes and is involved in the fusion of transport vesicles to their target membranes. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jun 2010]
- ENST00000262640
- ENSP00000262640
- ENSG00000124333
- ENST00000286448
- ENSP00000286448
- ENST00000460621
- ENSP00000427822
- SYBL1
- SYBL1
- TIVAMP
- VAMP-7
- TI-VAMP
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 0.95 | ||
histone modification site profile | 0.88 | ||
cellular component | 0.86 | ||
transcription factor perturbation | 0.84 | ||
interacting protein | 0.74 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 126.64 (req: < 5)
Gene RIFs: 35 (req: <= 3)
Antibodies: 202 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 126.64 (req: >= 5)
Gene RIFs: 35 (req: > 3)
Antibodies: 202 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 22
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (300)
1 – 10 of 300
STX12
Novelty: 0.03836262
p_int: 0.989579802
p_ni: 0.010420198
Score: 0.987
Data Source: BioPlex,STRINGDB
SNAP29
Novelty: 0.02009206
p_int: 0.9534844
p_ni: 0.0465156
Score: 0.996
Data Source: BioPlex,STRINGDB
SIRT2
Family: Epigenetic
Novelty: 0.00093962
p_int: 0.890779918
p_ni: 0.109220082
Score: 0.189
Data Source: BioPlex,STRINGDB
STX7
Novelty: 0.03109969
p_int: 0.841014952
p_ni: 0.158985048
Score: 0.985
Data Source: BioPlex,STRINGDB
GINM1
Novelty: 1.0701107
p_int: 0.837152411
p_ni: 0.162847589
Data Source: BioPlex
SNAP23
Novelty: 0.0065371
Score: 0.995
Data Source: Reactome,STRINGDB
STX6
Novelty: 0.01494028
Score: 0.99
Data Source: STRINGDB
STX4
Novelty: 0.00831588
Score: 0.988
Data Source: Reactome,STRINGDB
SNAP25
Novelty: 0.00148905
Score: 0.987
Data Source: STRINGDB
VAMP8
Novelty: 0.01083228
Score: 0.984
Data Source: STRINGDB
Pathways (13)
Reactome (12)
KEGG (1)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 12
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cargo recognition for clathrin-mediated endocytosis | ||||
Reactome | Clathrin-mediated endocytosis | ||||
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | Golgi Associated Vesicle Biogenesis | ||||
Reactome | Immune System | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cargo recognition for clathrin-mediated endocytosis | ||||
Clathrin-mediated endocytosis | ||||
Cytokine Signaling in Immune system | ||||
Golgi Associated Vesicle Biogenesis | ||||
Immune System | ||||
Gene Ontology Terms (48)
Functions (3)
Components (26)
Processes (19)
Items per page:
10
1 – 3 of 3
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
eosinophil percentage of leukocytes | 1 | 2 | 2 | 64 | |||||
eosinophil count | 1 | 2 | 2 | 58.3 | |||||
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
eosinophil percentage of leukocytes | 2 | 64 | |||||
eosinophil count | 2 | 58.3 | |||||
Find similar targets by:
UniProt Keyword
No Header | No Header | ||
|---|---|---|---|
MGI Phenotype
No Header | No Header | ||
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Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | vesicle associated membrane protein 7 | 704160 | ||||||
Mouse | MGI:1096399 | 20955 | ||||||
Rat | RGD:621558 | 85491 | ||||||
Dog | vesicle associated membrane protein 7 | VGNC:48226 | 612663 | |||||
Horse | vesicle associated membrane protein 7 | VGNC:24878 | 100062131 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | vesicle associated membrane protein 7 | |||||
Mouse | ||||||
Rat | ||||||
Dog | vesicle associated membrane protein 7 | |||||
Horse | vesicle associated membrane protein 7 | |||||
Publication Statistics
PubMed Score 126.64
PubMed score by year
PubTator Score 63.12
PubTator score by year