Tbio VAMP7 Vesicle-associated membrane protein 7

Protein Classes

PANTHER Classes

Protein / Membrane Traffic Protein / Snare Protein / Vesicle-associated Membrane Protein 7

DTO Classes

Protein / Transporter / Snare Protein / Vesicle-associated Membrane Protein 7

Protein Summary

Description

Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocytosis of late endocytic vesicles during phagosome formation. This gene encodes a transmembrane protein that is a member of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) family. The encoded protein localizes to late endosomes and lysosomes and is involved in the fusion of transport vesicles to their target membranes. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jun 2010]

Uniprot Accession IDs

• P51809
• Q53GY7
• Q7Z409
• Q9H4A7
• VAMP-7

Gene Name

• VAMP7

Ensembl ID

• ENST00000262640
• ENSP00000262640
• ENSG00000124333
• ENST00000286448
• ENSP00000286448
• ENST00000460621
• ENSP00000427822

Symbol

• SYBL1
• SYBL1
• TIVAMP
• VAMP-7
• TI-VAMP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.95
histone modification site profile	0.88
cellular component	0.86
transcription factor perturbation	0.84
interacting protein	0.74

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.32   (req: < 5)

Gene RIFs: 35   (req: <= 3)

Antibodies: 202   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.32   (req: >= 5)

Gene RIFs: 35   (req: > 3)

Antibodies: 202   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Data Bank (1)

1 – 1 of 1

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (13)

Reactome (12)

KEGG (1)

Cargo recognition for clathrin-mediated endocytosis (R-HSA-8856825)

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Items per page:

5

1 – 5 of 12

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cargo recognition for clathrin-mediated endocytosis	105 targets	R-HSA-8856825
Reactome	Clathrin-mediated endocytosis	143 targets	R-HSA-8856828
Reactome	Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Reactome	Golgi Associated Vesicle Biogenesis	56 targets	R-HSA-432722
Reactome	Immune System	2246 targets	R-HSA-168256

Name	Explore in Pharos	Explore in Source
Cargo recognition for clathrin-mediated endocytosis	105 targets	R-HSA-8856825
Clathrin-mediated endocytosis	143 targets	R-HSA-8856828
Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Golgi Associated Vesicle Biogenesis	56 targets	R-HSA-432722
Immune System	2246 targets	R-HSA-168256

Gene Ontology Terms (48)

Functions (3)

Components (26)

Processes (19)

Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
SNAP receptor activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
SNARE binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
syntaxin binding	Inferred from Electronic Annotation (IEA)	Ensembl

Protein-Protein Interactions (300)

Explore Interacting Targets

1 – 10 of 300

• See Interactions on String-DB

STX12

Tbio

Novelty: 0.07003045

p_int: 0.989579802

p_ni: 0.010420198

Score: 0.987

Data Source: BioPlex,STRINGDB

SNAP29

Tbio

Novelty: 0.02549569

p_int: 0.9534844

p_ni: 0.0465156

Score: 0.996

Data Source: BioPlex,STRINGDB

SIRT2

Tchem

Family: Epigenetic

Novelty: 0.00117896

p_int: 0.890779918

p_ni: 0.109220082

Score: 0.189

Data Source: BioPlex,STRINGDB

STX7

Tbio

Novelty: 0.052457

p_int: 0.841014952

p_ni: 0.158985048

Score: 0.985

Data Source: BioPlex,STRINGDB

GINM1

Tdark

p_int: 0.837152411

p_ni: 0.162847589

Data Source: BioPlex

SNAP23

Tbio

Novelty: 0.00732279

Score: 0.995

Data Source: Reactome,STRINGDB

STX6

Tbio

Novelty: 0.01577464

Score: 0.99

Data Source: STRINGDB

STX4

Tbio

Novelty: 0.01072491

Score: 0.988

Data Source: Reactome,STRINGDB

SNAP25

Tclin

Novelty: 0.0020914

Score: 0.987

Data Source: STRINGDB

VAMP8

Tbio

Novelty: 0.01382646

Score: 0.984

Data Source: STRINGDB

Publication Statistics

PubMed Score  91.32

PubMed score by year

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PubTator Score  63.12

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MAILFAVVARGTTILAKHAWCGGNFLEVTEQILAKIPSENNKLTYSHGNYLFHYICQDRIVYLCITDDDF

1-70

ERSRAFNFLNEIKKRFQTTYGSRAQTALPYAMNSEFSSVLAAQLKHHSENKGLDKVMETQAQVDELKGIM

70-140

VRNIDLVAQRGERLELLIDKTENLVDSSVTFKTTSRNLARAMCMKNLKLTIIIIIVSIVFIYIIVSPLCG

140-210

GFTWPSCVKK

210-220

MAILFAVVARGTTILAKHAWCGGNFLEVTEQILAKIPSENNKLTYSHGNYLFHYICQDRIVYLCITDDDFERSRAFNFLNEIKKRFQTTYGSRAQTALPYAMNSEFSSVLAAQLKHHSENKGLDKVMETQAQVDELKGIMVRNIDLVAQRGERLELLIDKTENLVDSSVTFKTTSRNLARAMCMKNLKLTIIIIIVSIVFIYIIVSPLCGGFTWPSCVKK

Find similar targets by:

Uniprot Keyword

3D-structure
Acetylation
Alternative splicing
Cell junction
Coiled coil
Complete proteome
Cytoplasmic vesicle
Direct protein sequencing
Endoplasmic reticulum
Endosome