Protein Summary
Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Regulates the migration of sympathetic neurons, but not of neural crest precursors. Required for normal dendrite spine morphology in pyramidal neurons. May play a role in regulating semaphorin-mediated programmed cell death in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. This gene encodes a member of the plexin class of proteins. The encoded protein is a class 3 semaphorin receptor, and may be involved in cytoskeletal remodeling and as well as apoptosis. Studies of a similar gene in zebrafish suggest that it is important for axon pathfinding in the develop ...more
- ENST00000369682
- ENSP00000358696
- ENSG00000130827
- PLXN4
- SEX
- 6.3
- PLXN3
- PLXN4
- XAP-6
- HSSEXGENE
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.99 | ||
biological process | 0.72 | ||
cell type or tissue | 0.71 | ||
histone modification site profile | 0.63 | ||
co-expressed gene | 0.61 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 31.42 (req: < 5)
Gene RIFs: 4 (req: <= 3)
Antibodies: 44 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 31.42 (req: >= 5)
Gene RIFs: 4 (req: > 3)
Antibodies: 44 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 19
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (108)
Nearest Tclin Targets (3)
Upstream (1)
Downstream (2)
1 – 1 of 1
Pathways (7)
Reactome (6)
KEGG (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Axon guidance | ||||
Reactome | CRMPs in Sema3A signaling | ||||
Reactome | Developmental Biology | ||||
Reactome | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | ||||
Reactome | Sema3A PAK dependent Axon repulsion | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Axon guidance | ||||
CRMPs in Sema3A signaling | ||||
Developmental Biology | ||||
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | ||||
Sema3A PAK dependent Axon repulsion | ||||
Viral Interactions (0)
Gene Ontology Terms (26)
Functions (2)
Components (7)
Processes (17)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Disease Associations ()
GWAS Traits (10)
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
HbA1c measurement | 3 | 1 | 3 | 87.7 | |||||
red blood cell distribution width | 1 | 1 | 1 | 79.3 | |||||
reticulocyte measurement | 1 | 1 | 1 | 74.6 | |||||
leukocyte count | 1 | 1 | 1 | 72.5 | |||||
erythrocyte count | 1 | 1 | 1 | 70.2 | |||||
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
HbA1c measurement | 3 | 87.7 | |||||
red blood cell distribution width | 1 | 79.3 | |||||
reticulocyte measurement | 1 | 74.6 | |||||
leukocyte count | 1 | 72.5 | |||||
erythrocyte count | 1 | 70.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | plexin A3 | 700399 | ||||||
Mouse | MGI:107683 | 18846 | ||||||
Rat | RGD:1584973 | 309280 | ||||||
Horse | plexin A3 | VGNC:21602 | 100058349 | |||||
Opossum | plexin A3 | 100022530 | ||||||
Publication Statistics
PubMed Score 31.42
PubMed score by year
PubTator Score 7.05
PubTator score by year
Related Publications
Text Mined References (17)
GeneRif Annotations (4)
Items per page:
0 of 0
PMID | Year | Title |
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