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Tchem
CLCNKA
Chloride channel protein ClC-Ka

Protein Summary
Description
Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms. This gene is a member of the CLC family of voltage-gated chloride channels. The encoded protein is predicted to have 12 transmembrane domains, and requires a beta subunit called barttin to form a functional channel. It is thought to function in salt reabsorption in the kidney and potassium recycling in the inner ear. The gene is highly similar to CLCNKB, which is located 10 kb downstream from this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331433
  • ENSP00000332771
  • ENSG00000186510
  • ENST00000375692
  • ENSP00000364844
  • ENST00000439316
  • ENSP00000414445

Symbol
  • CLCK1
  • ClC-K1
  • hClC-Ka
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.81
tissue sample
0.59
protein domain
0.58
cell line
0.51
metabolite
0.45


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.4   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 173   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.4   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 173   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (78)
BSND
Tbio
Novelty:  0.01638636
Score:  0.992
Data Source:  Reactome,STRINGDB
ANO1
Tclin
Family:  IC
Novelty:  0.00143722
Score:  0.768
Data Source:  STRINGDB
KLF15
Tbio
Family:  TF
Novelty:  0.009709
Score:  0.713
Data Source:  STRINGDB
SLC12A1
Tclin
Family:  Transporter
Novelty:  0.00303604
Score:  0.697
Data Source:  STRINGDB
KCNJ1
Tchem
Family:  IC
Novelty:  0.0025066
Score:  0.694
Data Source:  STRINGDB
SLC12A3
Tclin
Family:  Transporter
Novelty:  0.00199394
Score:  0.667
Data Source:  STRINGDB
ANO2
Tchem
Family:  IC
Novelty:  0.01239394
Score:  0.65
Data Source:  STRINGDB
AQP2
Tbio
Novelty:  0.00088471
Score:  0.647
Data Source:  STRINGDB
HSPB7
Tbio
Novelty:  0.03344805
Score:  0.634
Data Source:  STRINGDB
CLCNKB
Tchem
Family:  IC
Novelty:  0.00982208
Score:  0.628
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Ion channel transport (R-HSA-983712)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ion channel transport
Reactome
Stimuli-sensing channels
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Ion channel transport
Stimuli-sensing channels
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
1
8
8
98.6
heel bone mineral density
2
2
2
90.4
hematocrit
2
2
2
90
hemoglobin measurement
2
2
2
89.1
3
2
1
1.3
78.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
8
98.6
heel bone mineral density
2
90.4
hematocrit
2
90
hemoglobin measurement
2
89.1
1
1.3
78.4
Find similar targets by:
Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Cow
chloride channel Ka
538145
Anole lizard
chloride channel protein ClC-Kb
100557982
Species
Name
OMA
EggNOG
Inparanoid
Cow
chloride channel Ka
Anole lizard
chloride channel protein ClC-Kb
Publication Statistics
PubMed Score 42.40
PubMed score by year
PubTator Score 21.48
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title